Developmental aspect of decidual patterning
In clinical practice, early pregnancy loss has afflicted approximately 15%–25% women of reproductive age worldwide, which is partially attributed to defects associated with the endometrium. During pregnancy, the endometrial stromal cells experience remarkable tissue remodeling and transformation, te...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2017-01-01
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| Series: | Reproductive and Developmental Medicine |
| Subjects: | |
| Online Access: | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2017;volume=1;issue=2;spage=100;epage=114;aulast=Zhou |
| _version_ | 1818471028865630208 |
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| author | Chan Zhou Hai-Li Bao Shuang-Bo Kong Jin-Hua Lu Hai-Bin Wang |
| author_facet | Chan Zhou Hai-Li Bao Shuang-Bo Kong Jin-Hua Lu Hai-Bin Wang |
| author_sort | Chan Zhou |
| collection | DOAJ |
| description | In clinical practice, early pregnancy loss has afflicted approximately 15%–25% women of reproductive age worldwide, which is partially attributed to defects associated with the endometrium. During pregnancy, the endometrial stromal cells experience remarkable tissue remodeling and transformation, termed as decidualization, to support embryonic development, placental formation, and the maintenance of normal pregnancy in both mice and human. During this process, a series of dynamic developmental events, including rapid stromal proliferation, increased stromal cell size, enhanced angiogenesis, taken place in a highly-ordered manner under the precise regulation of steroid hormones. Meanwhile, diverse molecules exhibit spatiotemporal-specific expression pattern, implying their unique roles in decidual development. To achieve a more comprehensive understanding of these biological events and explore the underlying causes of early pregnancy disorders, this review emphasizes on the detailed developmental progression of decidual transformation and patterning as well as related pregnancy complications at the early stage of pregnancy. |
| first_indexed | 2024-04-13T21:45:35Z |
| format | Article |
| id | doaj.art-9e91228fcda74b7fb71c2f874e91142c |
| institution | Directory Open Access Journal |
| issn | 2096-2924 |
| language | English |
| last_indexed | 2024-04-13T21:45:35Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Reproductive and Developmental Medicine |
| spelling | doaj.art-9e91228fcda74b7fb71c2f874e91142c2022-12-22T02:28:35ZengWolters Kluwer Health/LWWReproductive and Developmental Medicine2096-29242017-01-011210011410.4103/2096-2924.216864Developmental aspect of decidual patterningChan ZhouHai-Li BaoShuang-Bo KongJin-Hua LuHai-Bin WangIn clinical practice, early pregnancy loss has afflicted approximately 15%–25% women of reproductive age worldwide, which is partially attributed to defects associated with the endometrium. During pregnancy, the endometrial stromal cells experience remarkable tissue remodeling and transformation, termed as decidualization, to support embryonic development, placental formation, and the maintenance of normal pregnancy in both mice and human. During this process, a series of dynamic developmental events, including rapid stromal proliferation, increased stromal cell size, enhanced angiogenesis, taken place in a highly-ordered manner under the precise regulation of steroid hormones. Meanwhile, diverse molecules exhibit spatiotemporal-specific expression pattern, implying their unique roles in decidual development. To achieve a more comprehensive understanding of these biological events and explore the underlying causes of early pregnancy disorders, this review emphasizes on the detailed developmental progression of decidual transformation and patterning as well as related pregnancy complications at the early stage of pregnancy.http://www.repdevmed.org/article.asp?issn=2096-2924;year=2017;volume=1;issue=2;spage=100;epage=114;aulast=ZhouDecidualization; Implantation; Mouse Model |
| spellingShingle | Chan Zhou Hai-Li Bao Shuang-Bo Kong Jin-Hua Lu Hai-Bin Wang Developmental aspect of decidual patterning Reproductive and Developmental Medicine Decidualization; Implantation; Mouse Model |
| title | Developmental aspect of decidual patterning |
| title_full | Developmental aspect of decidual patterning |
| title_fullStr | Developmental aspect of decidual patterning |
| title_full_unstemmed | Developmental aspect of decidual patterning |
| title_short | Developmental aspect of decidual patterning |
| title_sort | developmental aspect of decidual patterning |
| topic | Decidualization; Implantation; Mouse Model |
| url | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2017;volume=1;issue=2;spage=100;epage=114;aulast=Zhou |
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