Diagnostic and Prognostic Potential of Circulating Long Non-Coding RNAs in Non Small Cell Lung Cancer
Lung cancer is the leading cause of cancer-related mortality worldwide. Approximately 80% of lung cancer cases are non–small cell lung carcinoma (NSCLC). However current diagnostic and therapeutic modalities against NSCLC are ineffective due to incomplete understanding of molecular pathogenesis of N...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Cell Physiol Biochem Press GmbH & Co KG
2018-08-01
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| Series: | Cellular Physiology and Biochemistry |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/493043 |
| _version_ | 1819112392151269376 |
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| author | Wei Peng Jun Wang Bin Shan Zhenzi Peng Yeping Dong Wenwen Shi Dan He Yuanda Cheng Wenyuan Zhao Chunfang Zhang Bin Li Chaojun Duan |
| author_facet | Wei Peng Jun Wang Bin Shan Zhenzi Peng Yeping Dong Wenwen Shi Dan He Yuanda Cheng Wenyuan Zhao Chunfang Zhang Bin Li Chaojun Duan |
| author_sort | Wei Peng |
| collection | DOAJ |
| description | Lung cancer is the leading cause of cancer-related mortality worldwide. Approximately 80% of lung cancer cases are non–small cell lung carcinoma (NSCLC). However current diagnostic and therapeutic modalities against NSCLC are ineffective due to incomplete understanding of molecular pathogenesis of NSCLC. Emerging evidence shows that long non-coding RNAs (lncRNAs) can function as biomarkers for diagnosis and prognosis. LncRNAs can control transcription, translation, and protein function via diverse mechanisms although they lack the protein coding potential. LncRNAs have attracted intense investigations on their roles in cancer. Mounting evidence indicates that lncRNAs are promising biomarkers in diagnosis and prognosis for NSCLC, especially their presence in body fluids. Herein we will review recent advances in the research that explores the diagnostic and prognostic potentials of lncRNAs in NSCLC. We will also discuss emerging evidence that suggested lncRNAs as therapeutic targets in NSCLC. |
| first_indexed | 2024-12-22T04:12:47Z |
| format | Article |
| id | doaj.art-9e93facbbff54299b17aaadab56cd80b |
| institution | Directory Open Access Journal |
| issn | 1015-8987 1421-9778 |
| language | English |
| last_indexed | 2024-12-22T04:12:47Z |
| publishDate | 2018-08-01 |
| publisher | Cell Physiol Biochem Press GmbH & Co KG |
| record_format | Article |
| series | Cellular Physiology and Biochemistry |
| spelling | doaj.art-9e93facbbff54299b17aaadab56cd80b2022-12-21T18:39:29ZengCell Physiol Biochem Press GmbH & Co KGCellular Physiology and Biochemistry1015-89871421-97782018-08-0149281682710.1159/000493043493043Diagnostic and Prognostic Potential of Circulating Long Non-Coding RNAs in Non Small Cell Lung CancerWei PengJun WangBin ShanZhenzi PengYeping DongWenwen ShiDan HeYuanda ChengWenyuan ZhaoChunfang ZhangBin LiChaojun DuanLung cancer is the leading cause of cancer-related mortality worldwide. Approximately 80% of lung cancer cases are non–small cell lung carcinoma (NSCLC). However current diagnostic and therapeutic modalities against NSCLC are ineffective due to incomplete understanding of molecular pathogenesis of NSCLC. Emerging evidence shows that long non-coding RNAs (lncRNAs) can function as biomarkers for diagnosis and prognosis. LncRNAs can control transcription, translation, and protein function via diverse mechanisms although they lack the protein coding potential. LncRNAs have attracted intense investigations on their roles in cancer. Mounting evidence indicates that lncRNAs are promising biomarkers in diagnosis and prognosis for NSCLC, especially their presence in body fluids. Herein we will review recent advances in the research that explores the diagnostic and prognostic potentials of lncRNAs in NSCLC. We will also discuss emerging evidence that suggested lncRNAs as therapeutic targets in NSCLC.https://www.karger.com/Article/FullText/493043Lung cancerLong non-coding RNAsBiomarker |
| spellingShingle | Wei Peng Jun Wang Bin Shan Zhenzi Peng Yeping Dong Wenwen Shi Dan He Yuanda Cheng Wenyuan Zhao Chunfang Zhang Bin Li Chaojun Duan Diagnostic and Prognostic Potential of Circulating Long Non-Coding RNAs in Non Small Cell Lung Cancer Cellular Physiology and Biochemistry Lung cancer Long non-coding RNAs Biomarker |
| title | Diagnostic and Prognostic Potential of Circulating Long Non-Coding RNAs in Non Small Cell Lung Cancer |
| title_full | Diagnostic and Prognostic Potential of Circulating Long Non-Coding RNAs in Non Small Cell Lung Cancer |
| title_fullStr | Diagnostic and Prognostic Potential of Circulating Long Non-Coding RNAs in Non Small Cell Lung Cancer |
| title_full_unstemmed | Diagnostic and Prognostic Potential of Circulating Long Non-Coding RNAs in Non Small Cell Lung Cancer |
| title_short | Diagnostic and Prognostic Potential of Circulating Long Non-Coding RNAs in Non Small Cell Lung Cancer |
| title_sort | diagnostic and prognostic potential of circulating long non coding rnas in non small cell lung cancer |
| topic | Lung cancer Long non-coding RNAs Biomarker |
| url | https://www.karger.com/Article/FullText/493043 |
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