Safety and efficacy of zinc chelates of lysine and glutamic acid as feed additive for all animal species
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of zinc chelates of lysine and glutamic acid (Zinc‐LG) as a nutritional feed additive for all animal species. The EFSA Panel on Additives and Products or Substances us...
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| Format: | Article |
| Language: | English |
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Wiley
2019-07-01
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| Series: | EFSA Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.2903/j.efsa.2019.5782 |
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| author | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Francesco Cubadda Gerhard Flachowsky Alberto Mantovani Gloria López‐Gálvez Fernando Ramos |
| author_facet | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Francesco Cubadda Gerhard Flachowsky Alberto Mantovani Gloria López‐Gálvez Fernando Ramos |
| author_sort | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) |
| collection | DOAJ |
| description | Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of zinc chelates of lysine and glutamic acid (Zinc‐LG) as a nutritional feed additive for all animal species. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel concludes that, owing to safety considerations, the simultaneous use of both feed and water supplemented with Zinc‐LG should be avoided. Zinc‐LG is safe for chickens for fattening; this conclusion can be extrapolated to all animal species/categories provided that the maximum authorised levels in the EU for total zinc in feed are not exceeded. No increases in the zinc content of animal tissues and products are expected from the use of Zinc‐LG in animal nutrition. There is no indication that the toxicity of Zinc‐LG is essentially different from that described for inorganic divalent zinc. The use of Zinc‐LG in animal nutrition is of no concern for consumer safety provided that the maximum authorised total zinc levels in feed are respected. Owing to its zinc content, the handling of the additive poses a risk to users by inhalation. The additive is considered as a skin and respiratory sensitiser; it is non‐irritant to eye and to skin. Zinc‐LG is intended to be a substitute for other authorised zinc additives and will not further increase the environmental burden of zinc; therefore, the FEEDAP Panel considers that the use of the additive in animal nutrition would not pose an additional risk for the environment. Zinc‐LG is a source of bioavailable zinc, comparable to the standard inorganic zinc source, and therefore, the additive is efficacious in meeting the birds zinc requirements; this conclusion can be extrapolated to all animal species/categories. The FEEDAP Panel posed a recommendation concerning the description of the additive. |
| first_indexed | 2024-12-22T03:18:40Z |
| format | Article |
| id | doaj.art-9e9755eb384940e4979629194c7d4a10 |
| institution | Directory Open Access Journal |
| issn | 1831-4732 |
| language | English |
| last_indexed | 2024-12-22T03:18:40Z |
| publishDate | 2019-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj.art-9e9755eb384940e4979629194c7d4a102022-12-21T18:40:47ZengWileyEFSA Journal1831-47322019-07-01177n/an/a10.2903/j.efsa.2019.5782Safety and efficacy of zinc chelates of lysine and glutamic acid as feed additive for all animal speciesEFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Vasileios BampidisGiovanna AzimontiMaria de Lourdes BastosHenrik ChristensenBirgit DusemundMaryline KoubaMojca Kos DurjavaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaYolanda SanzRoberto Edoardo VillaRuud WoutersenFrancesco CubaddaGerhard FlachowskyAlberto MantovaniGloria López‐GálvezFernando RamosAbstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of zinc chelates of lysine and glutamic acid (Zinc‐LG) as a nutritional feed additive for all animal species. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel concludes that, owing to safety considerations, the simultaneous use of both feed and water supplemented with Zinc‐LG should be avoided. Zinc‐LG is safe for chickens for fattening; this conclusion can be extrapolated to all animal species/categories provided that the maximum authorised levels in the EU for total zinc in feed are not exceeded. No increases in the zinc content of animal tissues and products are expected from the use of Zinc‐LG in animal nutrition. There is no indication that the toxicity of Zinc‐LG is essentially different from that described for inorganic divalent zinc. The use of Zinc‐LG in animal nutrition is of no concern for consumer safety provided that the maximum authorised total zinc levels in feed are respected. Owing to its zinc content, the handling of the additive poses a risk to users by inhalation. The additive is considered as a skin and respiratory sensitiser; it is non‐irritant to eye and to skin. Zinc‐LG is intended to be a substitute for other authorised zinc additives and will not further increase the environmental burden of zinc; therefore, the FEEDAP Panel considers that the use of the additive in animal nutrition would not pose an additional risk for the environment. Zinc‐LG is a source of bioavailable zinc, comparable to the standard inorganic zinc source, and therefore, the additive is efficacious in meeting the birds zinc requirements; this conclusion can be extrapolated to all animal species/categories. The FEEDAP Panel posed a recommendation concerning the description of the additive.https://doi.org/10.2903/j.efsa.2019.5782nutritional additivescompounds of trace elementszinc chelates of lysine and glutamic acidProPath Znsafetyefficacy |
| spellingShingle | EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Vasileios Bampidis Giovanna Azimonti Maria de Lourdes Bastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Francesco Cubadda Gerhard Flachowsky Alberto Mantovani Gloria López‐Gálvez Fernando Ramos Safety and efficacy of zinc chelates of lysine and glutamic acid as feed additive for all animal species EFSA Journal nutritional additives compounds of trace elements zinc chelates of lysine and glutamic acid ProPath Zn safety efficacy |
| title | Safety and efficacy of zinc chelates of lysine and glutamic acid as feed additive for all animal species |
| title_full | Safety and efficacy of zinc chelates of lysine and glutamic acid as feed additive for all animal species |
| title_fullStr | Safety and efficacy of zinc chelates of lysine and glutamic acid as feed additive for all animal species |
| title_full_unstemmed | Safety and efficacy of zinc chelates of lysine and glutamic acid as feed additive for all animal species |
| title_short | Safety and efficacy of zinc chelates of lysine and glutamic acid as feed additive for all animal species |
| title_sort | safety and efficacy of zinc chelates of lysine and glutamic acid as feed additive for all animal species |
| topic | nutritional additives compounds of trace elements zinc chelates of lysine and glutamic acid ProPath Zn safety efficacy |
| url | https://doi.org/10.2903/j.efsa.2019.5782 |
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