Varied Responses to a High m.3243A>G Mutation Load and Respiratory Chain Dysfunction in Patient-Derived Cardiomyocytes

Varied Responses to a High m.3243A>G Mutation Load and Respiratory Chain Dysfunction in Patient-Derived Cardiomyocytes

The m.3243A>G mutation in mitochondrial <i>tRNA-Leu(UUR)</i> is one of the most common pathogenic mitochondrial DNA mutations in humans. The clinical manifestations are highly heterogenous and the causes for the drastic clinical variability are unknown. Approximately one third of pati...

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Bibliographic Details
Main Authors: Sanna Ryytty, Shalem R. Modi, Nikolay Naumenko, Anastasia Shakirzyanova, Muhammad Obaidur Rahman, Miia Vaara, Anu Suomalainen, Pasi Tavi, Riikka H. Hämäläinen
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
mitochondria
cardiomyopathy
mtDNA
iPS-cell
cardiomyocyte
respiratory chain dysfunction
Online Access:https://www.mdpi.com/2073-4409/11/16/2593

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