Characterization and mitigation of gene expression burden in mammalian cells
The design of genetic networks in mammalian cells is still slow and often fails. Here the authors show that miRNA-based incoherent feedforward loop circuits can be used to alleviate cellular burden.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18392-x |
| _version_ | 1818993697125040128 |
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| author | Timothy Frei Federica Cella Fabiana Tedeschi Joaquín Gutiérrez Guy-Bart Stan Mustafa Khammash Velia Siciliano |
| author_facet | Timothy Frei Federica Cella Fabiana Tedeschi Joaquín Gutiérrez Guy-Bart Stan Mustafa Khammash Velia Siciliano |
| author_sort | Timothy Frei |
| collection | DOAJ |
| description | The design of genetic networks in mammalian cells is still slow and often fails. Here the authors show that miRNA-based incoherent feedforward loop circuits can be used to alleviate cellular burden. |
| first_indexed | 2024-12-20T20:46:10Z |
| format | Article |
| id | doaj.art-9e9d2a9d032a4e53a995962e99e67a03 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:46:10Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9e9d2a9d032a4e53a995962e99e67a032022-12-21T19:27:02ZengNature PortfolioNature Communications2041-17232020-09-0111111410.1038/s41467-020-18392-xCharacterization and mitigation of gene expression burden in mammalian cellsTimothy Frei0Federica Cella1Fabiana Tedeschi2Joaquín Gutiérrez3Guy-Bart Stan4Mustafa Khammash5Velia Siciliano6Department of Biosystems Science and Engineering (D-BSSE), ETH ZürichIstituto Italiano di Tecnologia-IITIstituto Italiano di Tecnologia-IITDepartment of Biosystems Science and Engineering (D-BSSE), ETH ZürichDepartment of Bioengineering and Centre for Synthetic Biology, Imperial College LondonDepartment of Biosystems Science and Engineering (D-BSSE), ETH ZürichIstituto Italiano di Tecnologia-IITThe design of genetic networks in mammalian cells is still slow and often fails. Here the authors show that miRNA-based incoherent feedforward loop circuits can be used to alleviate cellular burden.https://doi.org/10.1038/s41467-020-18392-x |
| spellingShingle | Timothy Frei Federica Cella Fabiana Tedeschi Joaquín Gutiérrez Guy-Bart Stan Mustafa Khammash Velia Siciliano Characterization and mitigation of gene expression burden in mammalian cells Nature Communications |
| title | Characterization and mitigation of gene expression burden in mammalian cells |
| title_full | Characterization and mitigation of gene expression burden in mammalian cells |
| title_fullStr | Characterization and mitigation of gene expression burden in mammalian cells |
| title_full_unstemmed | Characterization and mitigation of gene expression burden in mammalian cells |
| title_short | Characterization and mitigation of gene expression burden in mammalian cells |
| title_sort | characterization and mitigation of gene expression burden in mammalian cells |
| url | https://doi.org/10.1038/s41467-020-18392-x |
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