On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls
The present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing featur...
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| Format: | Article |
| Language: | English |
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Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
1995-01-01
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| Series: | Cadernos de Saúde Pública |
| Subjects: | |
| Online Access: | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018 |
| _version_ | 1818480247871373312 |
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| author | Costa Eduardo de A. |
| author_facet | Costa Eduardo de A. |
| author_sort | Costa Eduardo de A. |
| collection | DOAJ |
| description | The present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease. |
| first_indexed | 2024-12-10T11:20:53Z |
| format | Article |
| id | doaj.art-9e9d592918314e17bc77c9adda64a268 |
| institution | Directory Open Access Journal |
| issn | 0102-311X 1678-4464 |
| language | English |
| last_indexed | 2024-12-10T11:20:53Z |
| publishDate | 1995-01-01 |
| publisher | Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz |
| record_format | Article |
| series | Cadernos de Saúde Pública |
| spelling | doaj.art-9e9d592918314e17bc77c9adda64a2682022-12-22T01:50:56ZengEscola Nacional de Saúde Pública, Fundação Oswaldo CruzCadernos de Saúde Pública0102-311X1678-44641995-01-01112332335On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfallsCosta Eduardo de A.The present communication analyses methodological problems related to evaluating the protection given by the antimeningococcal B vaccine to children under four years of age in a case-control study carried out in Sao Paulo, Brazil. Detection of a hospital selection bias, among other disturbing features of the study, suggests that the efficacy of the vaccine was underestimated. Altogether, data presented support a wider use of the Cuban-produced vaccine to reduce morbidity and mortality from serogroup B meningococcal disease.http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018Meningococcal DiseaseCase-selection BiasAnti-meningococcal B VaccineVaccine EfficacyNeisseria meningitidis |
| spellingShingle | Costa Eduardo de A. On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls Cadernos de Saúde Pública Meningococcal Disease Case-selection Bias Anti-meningococcal B Vaccine Vaccine Efficacy Neisseria meningitidis |
| title | On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| title_full | On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| title_fullStr | On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| title_full_unstemmed | On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| title_short | On the controversy about the efficacy of the antimeningococcal B vaccine: methodological pitfalls |
| title_sort | on the controversy about the efficacy of the antimeningococcal b vaccine methodological pitfalls |
| topic | Meningococcal Disease Case-selection Bias Anti-meningococcal B Vaccine Vaccine Efficacy Neisseria meningitidis |
| url | http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0102-311X1995000200018 |
| work_keys_str_mv | AT costaeduardodea onthecontroversyabouttheefficacyoftheantimeningococcalbvaccinemethodologicalpitfalls |