Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy
Photothermal therapy can induce an anti-tumour immune response by producing tumour-associated antigens. Here, the authors design a nanoparticle that simultaneously acts as a photothermal agent and an immune-adjuvant and demonstrate the anti-tumour efficacy in combination with anti-CTLA4 therapy in p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13193 |
| _version_ | 1818855806745968640 |
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| author | Qian Chen Ligeng Xu Chao Liang Chao Wang Rui Peng Zhuang Liu |
| author_facet | Qian Chen Ligeng Xu Chao Liang Chao Wang Rui Peng Zhuang Liu |
| author_sort | Qian Chen |
| collection | DOAJ |
| description | Photothermal therapy can induce an anti-tumour immune response by producing tumour-associated antigens. Here, the authors design a nanoparticle that simultaneously acts as a photothermal agent and an immune-adjuvant and demonstrate the anti-tumour efficacy in combination with anti-CTLA4 therapy in preclinical murine cancer models. |
| first_indexed | 2024-12-19T08:14:28Z |
| format | Article |
| id | doaj.art-9e9e6fa3c41a409f8b926964a73429b3 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:14:28Z |
| publishDate | 2016-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9e9e6fa3c41a409f8b926964a73429b32022-12-21T20:29:33ZengNature PortfolioNature Communications2041-17232016-10-017111310.1038/ncomms13193Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapyQian Chen0Ligeng Xu1Chao Liang2Chao Wang3Rui Peng4Zhuang Liu5Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow UniversityInstitute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow UniversityInstitute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow UniversityInstitute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow UniversityInstitute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow UniversityInstitute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow UniversityPhotothermal therapy can induce an anti-tumour immune response by producing tumour-associated antigens. Here, the authors design a nanoparticle that simultaneously acts as a photothermal agent and an immune-adjuvant and demonstrate the anti-tumour efficacy in combination with anti-CTLA4 therapy in preclinical murine cancer models.https://doi.org/10.1038/ncomms13193 |
| spellingShingle | Qian Chen Ligeng Xu Chao Liang Chao Wang Rui Peng Zhuang Liu Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy Nature Communications |
| title | Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy |
| title_full | Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy |
| title_fullStr | Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy |
| title_full_unstemmed | Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy |
| title_short | Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy |
| title_sort | photothermal therapy with immune adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy |
| url | https://doi.org/10.1038/ncomms13193 |
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