Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1)
The use of nanoparticles (NPs) is rapidly increasing in nuclear medicine (NM) for diagnostic and therapeutic purposes. Their wide use is due to their chemical–physical characteristics and possibility to deliver several molecules. NPs can be synthetised by organic and/or inorganic materials and they...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/12/10/1522 |
| _version_ | 1797474867304464384 |
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| author | Michela Varani Valeria Bentivoglio Chiara Lauri Danilo Ranieri Alberto Signore |
| author_facet | Michela Varani Valeria Bentivoglio Chiara Lauri Danilo Ranieri Alberto Signore |
| author_sort | Michela Varani |
| collection | DOAJ |
| description | The use of nanoparticles (NPs) is rapidly increasing in nuclear medicine (NM) for diagnostic and therapeutic purposes. Their wide use is due to their chemical–physical characteristics and possibility to deliver several molecules. NPs can be synthetised by organic and/or inorganic materials and they can have different size, shape, chemical composition, and charge. These factors influence their biodistribution, clearance, and targeting ability in vivo. NPs can be designed to encapsulate inside the core or bind to the surface several molecules, including radionuclides, for different clinical applications. Either diagnostic or therapeutic radioactive NPs can be synthetised, making a so-called theragnostic tool. To date, there are several methods for radiolabelling NPs that vary depending on both the physical and chemical properties of the NPs and on the isotope used. In this review, we analysed and compared different methods for radiolabelling NPs for single-photon emission computed tomography (SPECT) use. |
| first_indexed | 2024-03-09T20:36:09Z |
| format | Article |
| id | doaj.art-9e9f7297251c4f62bdd317cb85beb8e6 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-09T20:36:09Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-9e9f7297251c4f62bdd317cb85beb8e62023-11-23T23:09:58ZengMDPI AGBiomolecules2218-273X2022-10-011210152210.3390/biom12101522Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1)Michela Varani0Valeria Bentivoglio1Chiara Lauri2Danilo Ranieri3Alberto Signore4Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, “Sapienza” University of Rome, 00189 Roma, ItalyNuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, “Sapienza” University of Rome, 00189 Roma, ItalyNuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, “Sapienza” University of Rome, 00189 Roma, ItalyDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, “Sapienza” University of Rome, 00189 Roma, ItalyNuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Faculty of Medicine and Psychology, “Sapienza” University of Rome, 00189 Roma, ItalyThe use of nanoparticles (NPs) is rapidly increasing in nuclear medicine (NM) for diagnostic and therapeutic purposes. Their wide use is due to their chemical–physical characteristics and possibility to deliver several molecules. NPs can be synthetised by organic and/or inorganic materials and they can have different size, shape, chemical composition, and charge. These factors influence their biodistribution, clearance, and targeting ability in vivo. NPs can be designed to encapsulate inside the core or bind to the surface several molecules, including radionuclides, for different clinical applications. Either diagnostic or therapeutic radioactive NPs can be synthetised, making a so-called theragnostic tool. To date, there are several methods for radiolabelling NPs that vary depending on both the physical and chemical properties of the NPs and on the isotope used. In this review, we analysed and compared different methods for radiolabelling NPs for single-photon emission computed tomography (SPECT) use.https://www.mdpi.com/2218-273X/12/10/1522nanoparticlesnanotechnologynuclear medicineradiolabellingSPECT/CT |
| spellingShingle | Michela Varani Valeria Bentivoglio Chiara Lauri Danilo Ranieri Alberto Signore Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1) Biomolecules nanoparticles nanotechnology nuclear medicine radiolabelling SPECT/CT |
| title | Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1) |
| title_full | Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1) |
| title_fullStr | Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1) |
| title_full_unstemmed | Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1) |
| title_short | Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1) |
| title_sort | methods for radiolabelling nanoparticles spect use part 1 |
| topic | nanoparticles nanotechnology nuclear medicine radiolabelling SPECT/CT |
| url | https://www.mdpi.com/2218-273X/12/10/1522 |
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