HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian Federation
Most HIV-1 tropism studies have involved non-A subtypes. Our aim was to study the prevalence of R5- and non-R5-tropic HIV-1 variants and the tropism occurrence relative to the CD4 counts, treatment experiences, transmission routes and other features of infection in Russia, where subtype A is presuma...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-01-01
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| Series: | Cogent Medicine |
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| Online Access: | http://dx.doi.org/10.1080/2331205X.2017.1311470 |
| _version_ | 1811201146316914688 |
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| author | Alexey Lopatukhin Dmitry Kireev Dmitry Kuevda Anastasia Pokrovskaya Galina Tsyganova Galina Korovina Alexander Pinsker Natalia Dementeva Natalia Sizova Olga Peksheva Natalia Zaytseva Nikolai Nosov Nail Urazov Valery Gerasimov Natalia Ermolinskaya Natalia Gerasimova Tatyana Sandyreva Ludmila Volova Lilia Grezina Anna Kolomeets Irina Sergeeva Dmitry Neshumaev Anatoly Boyko Valeria Kotova Ludmila Balakhontseva Dmitry Kolpakov Andrey Shemshura Sergey Saukhat Evgeniy Bukin Andrey Polyakov Rolf Kaiser German Shipulin Vadim Pokrovsky |
| author_facet | Alexey Lopatukhin Dmitry Kireev Dmitry Kuevda Anastasia Pokrovskaya Galina Tsyganova Galina Korovina Alexander Pinsker Natalia Dementeva Natalia Sizova Olga Peksheva Natalia Zaytseva Nikolai Nosov Nail Urazov Valery Gerasimov Natalia Ermolinskaya Natalia Gerasimova Tatyana Sandyreva Ludmila Volova Lilia Grezina Anna Kolomeets Irina Sergeeva Dmitry Neshumaev Anatoly Boyko Valeria Kotova Ludmila Balakhontseva Dmitry Kolpakov Andrey Shemshura Sergey Saukhat Evgeniy Bukin Andrey Polyakov Rolf Kaiser German Shipulin Vadim Pokrovsky |
| author_sort | Alexey Lopatukhin |
| collection | DOAJ |
| description | Most HIV-1 tropism studies have involved non-A subtypes. Our aim was to study the prevalence of R5- and non-R5-tropic HIV-1 variants and the tropism occurrence relative to the CD4 counts, treatment experiences, transmission routes and other features of infection in Russia, where subtype A is presumably predominant. In this multicenter, single-step, cross-sectional, epidemiologic study, 943 HIV-1-infected patients were enrolled at 12 AIDS centers throughout Russia. Viral tropism was determined using a genotype method-based kit. The V3 loop sequences were analyzed using the geno2pheno resource. The tropism was successfully predicted for 823 (87.3%) patients. Frequencies of R5-tropic and non-R5-tropic viruses in successfully analyzed samples were 70.2% (578) and 29.8% (245), respectively. Co-receptor usage correlated significantly only with the treatment experiences (p = 0.018) and CD4 counts (p = 0.004). But there was no dependence of R5/non-R5 co-receptor usage frequencies on presence/absence of a therapy change (p = 0.664) or HIV infection duration (p = 0.458). According to the env sequences, 457 (83.6%) of the samples in study were subtype A and 70 (12.8%) were subtype B. This indicates a stabilizing of immune system and thus little emergence of X4 viruses. We suggest that CCR5-antagonists could be used in both naïve and experienced patients in Russia after determination of HIV tropism. |
| first_indexed | 2024-04-12T02:16:54Z |
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| id | doaj.art-9e9f7a09507f4aa5b74b9085266dd1d4 |
| institution | Directory Open Access Journal |
| issn | 2331-205X |
| language | English |
| last_indexed | 2024-04-12T02:16:54Z |
| publishDate | 2017-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Cogent Medicine |
| spelling | doaj.art-9e9f7a09507f4aa5b74b9085266dd1d42022-12-22T03:52:14ZengTaylor & Francis GroupCogent Medicine2331-205X2017-01-014110.1080/2331205X.2017.13114701311470HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian FederationAlexey Lopatukhin0Dmitry Kireev1Dmitry Kuevda2Anastasia Pokrovskaya3Galina Tsyganova4Galina Korovina5Alexander Pinsker6Natalia Dementeva7Natalia Sizova8Olga Peksheva9Natalia Zaytseva10Nikolai Nosov11Nail Urazov12Valery Gerasimov13Natalia Ermolinskaya14Natalia Gerasimova15Tatyana Sandyreva16Ludmila Volova17Lilia Grezina18Anna Kolomeets19Irina Sergeeva20Dmitry Neshumaev21Anatoly Boyko22Valeria Kotova23Ludmila Balakhontseva24Dmitry Kolpakov25Andrey Shemshura26Sergey Saukhat27Evgeniy Bukin28Andrey Polyakov29Rolf Kaiser30German Shipulin31Vadim Pokrovsky32Central Research Institute for Epidemiology of RospotrebnadzorCentral Research Institute for Epidemiology of RospotrebnadzorCentral Research Institute for Epidemiology of RospotrebnadzorCentral Research Institute for Epidemiology of RospotrebnadzorCentral Research Institute for Epidemiology of RospotrebnadzorRepublican Clinical Infectious Diseases Hospital - Research Center of Prevention and Treatment of HIV Infection in Children and Pregnant Women of the Ministry of Health and Social Development of the Russian FederationRepublican Clinical Infectious Diseases Hospital - Research Center of Prevention and Treatment of HIV Infection in Children and Pregnant Women of the Ministry of Health and Social Development of the Russian FederationSt. Petersburg Center for Control of AIDS and Infectious DiseasesSt. Petersburg Center for Control of AIDS and Infectious DiseasesFederal Budget Institution of Science “Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology Named After Academician I.N. Blokhina” of Rospotrebnadzor, Privolzhsky Okrug Centre of AIDS Prophylaxis and ControlFederal Budget Institution of Science “Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology Named After Academician I.N. Blokhina” of Rospotrebnadzor, Privolzhsky Okrug Centre of AIDS Prophylaxis and ControlFederal Budget Institution of Science “Nizhny Novgorod Scientific and Research Institute of Epidemiology and Microbiology Named After Academician I.N. Blokhina” of Rospotrebnadzor, Privolzhsky Okrug Centre of AIDS Prophylaxis and ControlRepublican Center for Prophylaxis and Control of AIDS and Infectious DiseasesRepublican Center for Prophylaxis and Control of AIDS and Infectious DiseasesFSIS Yekaterinburg Research Institute of Viral Infections of RospotrebnadzorRegional Centre for AIDS PreventionRegional Centre for AIDS PreventionYamal-Nenets Autonomous District Center for Prevention and Control of AIDS and Infectious DiseasesYamal-Nenets Autonomous District Center for Prevention and Control of AIDS and Infectious DiseasesOmsk Research Institute of Natural Focal Infections, Siberian Federal District Center for AIDS Prevention and FightOmsk Research Institute of Natural Focal Infections, Siberian Federal District Center for AIDS Prevention and FightKrasnoyarsk Regional Centre of AIDS PreventionKrasnoyarsk Regional Centre of AIDS PreventionKhabarovsk Research Institute of Epidemiology and MicrobiologyKhabarovsk Research Institute of Epidemiology and MicrobiologyRostov Research Institute of Microbiology and ParasitologyRostov Research Institute of Microbiology and ParasitologyRostov Research Institute of Microbiology and ParasitologyViiV Healthcare RussiaViiV Healthcare RussiaInstitute of Virology, University of KölnCentral Research Institute for Epidemiology of RospotrebnadzorCentral Research Institute for Epidemiology of RospotrebnadzorMost HIV-1 tropism studies have involved non-A subtypes. Our aim was to study the prevalence of R5- and non-R5-tropic HIV-1 variants and the tropism occurrence relative to the CD4 counts, treatment experiences, transmission routes and other features of infection in Russia, where subtype A is presumably predominant. In this multicenter, single-step, cross-sectional, epidemiologic study, 943 HIV-1-infected patients were enrolled at 12 AIDS centers throughout Russia. Viral tropism was determined using a genotype method-based kit. The V3 loop sequences were analyzed using the geno2pheno resource. The tropism was successfully predicted for 823 (87.3%) patients. Frequencies of R5-tropic and non-R5-tropic viruses in successfully analyzed samples were 70.2% (578) and 29.8% (245), respectively. Co-receptor usage correlated significantly only with the treatment experiences (p = 0.018) and CD4 counts (p = 0.004). But there was no dependence of R5/non-R5 co-receptor usage frequencies on presence/absence of a therapy change (p = 0.664) or HIV infection duration (p = 0.458). According to the env sequences, 457 (83.6%) of the samples in study were subtype A and 70 (12.8%) were subtype B. This indicates a stabilizing of immune system and thus little emergence of X4 viruses. We suggest that CCR5-antagonists could be used in both naïve and experienced patients in Russia after determination of HIV tropism.http://dx.doi.org/10.1080/2331205X.2017.1311470receptors, ccr5receptors, cxcr4molecular epidemiologyhiv-1russia |
| spellingShingle | Alexey Lopatukhin Dmitry Kireev Dmitry Kuevda Anastasia Pokrovskaya Galina Tsyganova Galina Korovina Alexander Pinsker Natalia Dementeva Natalia Sizova Olga Peksheva Natalia Zaytseva Nikolai Nosov Nail Urazov Valery Gerasimov Natalia Ermolinskaya Natalia Gerasimova Tatyana Sandyreva Ludmila Volova Lilia Grezina Anna Kolomeets Irina Sergeeva Dmitry Neshumaev Anatoly Boyko Valeria Kotova Ludmila Balakhontseva Dmitry Kolpakov Andrey Shemshura Sergey Saukhat Evgeniy Bukin Andrey Polyakov Rolf Kaiser German Shipulin Vadim Pokrovsky HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian Federation Cogent Medicine receptors, ccr5 receptors, cxcr4 molecular epidemiology hiv-1 russia |
| title | HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian Federation |
| title_full | HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian Federation |
| title_fullStr | HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian Federation |
| title_full_unstemmed | HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian Federation |
| title_short | HIV-1 genotyping tropism profile in an HIV-positive population throughout the Russian Federation |
| title_sort | hiv 1 genotyping tropism profile in an hiv positive population throughout the russian federation |
| topic | receptors, ccr5 receptors, cxcr4 molecular epidemiology hiv-1 russia |
| url | http://dx.doi.org/10.1080/2331205X.2017.1311470 |
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