Regulated cell death: Implications for intervertebral disc degeneration and therapy
As a controllable biological process, regulated cell death (RCD) extensively participates in cellular homeostasis, organismal development, and the pathogenesis of diseases. This review addresses the research gaps by synthesising the findings on the complexity of RCD modes and their role in disc dege...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Journal of Orthopaedic Translation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X22001097 |
| _version_ | 1797961133034831872 |
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| author | Fan Yang Weijian Liu Yongcan Huang Shuhua Yang Zengwu Shao Xianyi Cai Liming Xiong |
| author_facet | Fan Yang Weijian Liu Yongcan Huang Shuhua Yang Zengwu Shao Xianyi Cai Liming Xiong |
| author_sort | Fan Yang |
| collection | DOAJ |
| description | As a controllable biological process, regulated cell death (RCD) extensively participates in cellular homeostasis, organismal development, and the pathogenesis of diseases. This review addresses the research gaps by synthesising the findings on the complexity of RCD modes and their role in disc degeneration, and summarises the preclinical strategies to alleviate disc degeneration and promote disc repair by regulating RCD. Background: Intervertebral disc degeneration (IDD) is the major source of chronic low back pain. As a controllable biological process, regulated cell death (RCD) extensively participates in the pathogenesis of IDD. Nevertheless, the initiation and progression of RCD remain unclear, and more importantly, the interaction between different RCD modes during IDD and therapy is far from well understood. Methods: Literature search was performed using “regulated cell death AND intervertebral disc degeneration” in PubMed, Embase, and Web of Science. Meanwhile, relevant findings have been reviewed and quoted. Results: In this review, we discuss the inducing factors of IDD, various modes of RCD in intervertebral disc, the interactions between different RCD modes, as well as the obstacles to achieve disc regeneration. Meanwhile, the research gaps and perspective in studies that targeting RCD are also presented. Conclusion: Increasing evidence demonstrated the presence of different RCD modes in intervertebral disc during the progression of IDD. RCD in the resident disc cells is probably induced by the multiple factors such as abnormal mechanical loading, nutritional imbalance, inflammation microenvironment, circadian rhythm changes, withdraw of hormones, and other biomechanical factors. A better understanding of the fundamental mechanisms and the interactions between different RCD modes might contribute to the rescuing of disc degeneration and development of promising therapeutics. Translational potential statement: The Translational potential of this article. This review aims to demonstrate a better understanding of the fundamental mechanisms governing RCD, which might contribute to the rescuing of disc degeneration and to the development of promising therapeutics in a clinical setting. |
| first_indexed | 2024-04-11T00:54:38Z |
| format | Article |
| id | doaj.art-9e9facea6e154b2f99c345ecaa9ea99e |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-04-11T00:54:38Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-9e9facea6e154b2f99c345ecaa9ea99e2023-01-05T06:24:10ZengElsevierJournal of Orthopaedic Translation2214-031X2022-11-0137163172Regulated cell death: Implications for intervertebral disc degeneration and therapyFan Yang0Weijian Liu1Yongcan Huang2Shuhua Yang3Zengwu Shao4Xianyi Cai5Liming Xiong6Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaShenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen, ChinaDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Orthopaedics, Hefeng Central Hospital, Enshi, China; Corresponding author. Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Corresponding author.As a controllable biological process, regulated cell death (RCD) extensively participates in cellular homeostasis, organismal development, and the pathogenesis of diseases. This review addresses the research gaps by synthesising the findings on the complexity of RCD modes and their role in disc degeneration, and summarises the preclinical strategies to alleviate disc degeneration and promote disc repair by regulating RCD. Background: Intervertebral disc degeneration (IDD) is the major source of chronic low back pain. As a controllable biological process, regulated cell death (RCD) extensively participates in the pathogenesis of IDD. Nevertheless, the initiation and progression of RCD remain unclear, and more importantly, the interaction between different RCD modes during IDD and therapy is far from well understood. Methods: Literature search was performed using “regulated cell death AND intervertebral disc degeneration” in PubMed, Embase, and Web of Science. Meanwhile, relevant findings have been reviewed and quoted. Results: In this review, we discuss the inducing factors of IDD, various modes of RCD in intervertebral disc, the interactions between different RCD modes, as well as the obstacles to achieve disc regeneration. Meanwhile, the research gaps and perspective in studies that targeting RCD are also presented. Conclusion: Increasing evidence demonstrated the presence of different RCD modes in intervertebral disc during the progression of IDD. RCD in the resident disc cells is probably induced by the multiple factors such as abnormal mechanical loading, nutritional imbalance, inflammation microenvironment, circadian rhythm changes, withdraw of hormones, and other biomechanical factors. A better understanding of the fundamental mechanisms and the interactions between different RCD modes might contribute to the rescuing of disc degeneration and development of promising therapeutics. Translational potential statement: The Translational potential of this article. This review aims to demonstrate a better understanding of the fundamental mechanisms governing RCD, which might contribute to the rescuing of disc degeneration and to the development of promising therapeutics in a clinical setting.http://www.sciencedirect.com/science/article/pii/S2214031X22001097Regulated cell deathIntervertebral disc degenerationLow back painApoptosisNecroptosis |
| spellingShingle | Fan Yang Weijian Liu Yongcan Huang Shuhua Yang Zengwu Shao Xianyi Cai Liming Xiong Regulated cell death: Implications for intervertebral disc degeneration and therapy Journal of Orthopaedic Translation Regulated cell death Intervertebral disc degeneration Low back pain Apoptosis Necroptosis |
| title | Regulated cell death: Implications for intervertebral disc degeneration and therapy |
| title_full | Regulated cell death: Implications for intervertebral disc degeneration and therapy |
| title_fullStr | Regulated cell death: Implications for intervertebral disc degeneration and therapy |
| title_full_unstemmed | Regulated cell death: Implications for intervertebral disc degeneration and therapy |
| title_short | Regulated cell death: Implications for intervertebral disc degeneration and therapy |
| title_sort | regulated cell death implications for intervertebral disc degeneration and therapy |
| topic | Regulated cell death Intervertebral disc degeneration Low back pain Apoptosis Necroptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X22001097 |
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