Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children
Abstract High concentrations of carotenoids are protective against cardiometabolic risk traits (CMTs) in adults and children. We recently showed in non-diabetic Mexican American (MA) children that serum α-carotene and β-carotene are inversely correlated with obesity measures and triglycerides and po...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-020-79387-8 |
| _version_ | 1830192667498119168 |
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| author | Srinivas Mummidi Vidya S. Farook Lavanya Reddivari Joselin Hernandez-Ruiz Alvaro Diaz-Badillo Sharon P. Fowler Roy G. Resendez Feroz Akhtar Donna M. Lehman Christopher P. Jenkinson Rector Arya Jane L. Lynch Jose A. Canas Ralph A. DeFronzo Daniel E. Hale John Blangero Juan Carlos Lopez-Alvarenga Ravindranath Duggirala Jairam K. P. Vanamala |
| author_facet | Srinivas Mummidi Vidya S. Farook Lavanya Reddivari Joselin Hernandez-Ruiz Alvaro Diaz-Badillo Sharon P. Fowler Roy G. Resendez Feroz Akhtar Donna M. Lehman Christopher P. Jenkinson Rector Arya Jane L. Lynch Jose A. Canas Ralph A. DeFronzo Daniel E. Hale John Blangero Juan Carlos Lopez-Alvarenga Ravindranath Duggirala Jairam K. P. Vanamala |
| author_sort | Srinivas Mummidi |
| collection | DOAJ |
| description | Abstract High concentrations of carotenoids are protective against cardiometabolic risk traits (CMTs) in adults and children. We recently showed in non-diabetic Mexican American (MA) children that serum α-carotene and β-carotene are inversely correlated with obesity measures and triglycerides and positively with HDL cholesterol and that they were under strong genetic influences. Additionally, we previously described a Pediatric Metabolic Index (PMI) that helps in the identification of children who are at risk for cardiometabolic diseases. Here, we quantified serum lycopene and β-cryptoxanthin concentrations in approximately 580 children from MA families using an ultraperformance liquid chromatography-photodiode array and determined their heritabilities and correlations with CMTs. Using response surface methodology (RSM), we determined two-way interactions of carotenoids and PMI on Matsuda insulin sensitivity index (ISI). The concentrations of lycopene and β-cryptoxanthin were highly heritable [h2 = 0.98, P = 7 × 10–18 and h2 = 0.58, P = 1 × 10–7]. We found significant (P ≤ 0.05) negative phenotypic correlations between β-cryptoxanthin and five CMTs: body mass index (− 0.22), waist circumference (− 0.25), triglycerides (− 0.18), fat mass (− 0.23), fasting glucose (− 0.09), and positive correlations with HDL cholesterol (0.29). In contrast, lycopene only showed a significant negative correlation with fasting glucose (− 0.08) and a positive correlation with HDL cholesterol (0.18). Importantly, we found that common genetic influences significantly contributed to the observed phenotypic correlations. RSM showed that increased serum concentrations of α- and β-carotenoids rather than that of β-cryptoxanthin or lycopene had maximal effects on ISI. In summary, our findings suggest that the serum carotenoids are under strong additive genetic influences and may have differential effects on susceptibility to CMTs in children. |
| first_indexed | 2024-12-17T23:58:58Z |
| format | Article |
| id | doaj.art-9ea1b2d9197f435c9d2ab4be8f69edf9 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T23:58:58Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9ea1b2d9197f435c9d2ab4be8f69edf92022-12-21T21:27:59ZengNature PortfolioScientific Reports2045-23222021-01-0111111110.1038/s41598-020-79387-8Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American childrenSrinivas Mummidi0Vidya S. Farook1Lavanya Reddivari2Joselin Hernandez-Ruiz3Alvaro Diaz-Badillo4Sharon P. Fowler5Roy G. Resendez6Feroz Akhtar7Donna M. Lehman8Christopher P. Jenkinson9Rector Arya10Jane L. Lynch11Jose A. Canas12Ralph A. DeFronzo13Daniel E. Hale14John Blangero15Juan Carlos Lopez-Alvarenga16Ravindranath Duggirala17Jairam K. P. Vanamala18South Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande ValleySouth Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande ValleyDepartment of Food Science, Purdue UniversityClinical Pharmacology Unit, Hospital General de México Dr. Eduardo LiceagaSouth Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande ValleySchool of Public Health, University of Texas Health HoustonSouth Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande ValleySouth Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande ValleyDepartment of Medicine, School of Medicine, University of Texas Health San AntonioSouth Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande ValleySouth Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande ValleyDepartment of Pediatrics, School of Medicine, University of Texas Health San AntonioJohns Hopkins All Children’s HospitalDepartment of Medicine, School of Medicine, University of Texas Health San AntonioDepartment of Pediatrics, Penn State Health Milton S. Hershey Medical CenterSouth Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande ValleySouth Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande ValleySouth Texas Diabetes and Obesity Institute, Department of Human Genetics, School of Medicine, University of Texas Rio Grande ValleyDepartment of Food Science, Pennsylvania State UniversityAbstract High concentrations of carotenoids are protective against cardiometabolic risk traits (CMTs) in adults and children. We recently showed in non-diabetic Mexican American (MA) children that serum α-carotene and β-carotene are inversely correlated with obesity measures and triglycerides and positively with HDL cholesterol and that they were under strong genetic influences. Additionally, we previously described a Pediatric Metabolic Index (PMI) that helps in the identification of children who are at risk for cardiometabolic diseases. Here, we quantified serum lycopene and β-cryptoxanthin concentrations in approximately 580 children from MA families using an ultraperformance liquid chromatography-photodiode array and determined their heritabilities and correlations with CMTs. Using response surface methodology (RSM), we determined two-way interactions of carotenoids and PMI on Matsuda insulin sensitivity index (ISI). The concentrations of lycopene and β-cryptoxanthin were highly heritable [h2 = 0.98, P = 7 × 10–18 and h2 = 0.58, P = 1 × 10–7]. We found significant (P ≤ 0.05) negative phenotypic correlations between β-cryptoxanthin and five CMTs: body mass index (− 0.22), waist circumference (− 0.25), triglycerides (− 0.18), fat mass (− 0.23), fasting glucose (− 0.09), and positive correlations with HDL cholesterol (0.29). In contrast, lycopene only showed a significant negative correlation with fasting glucose (− 0.08) and a positive correlation with HDL cholesterol (0.18). Importantly, we found that common genetic influences significantly contributed to the observed phenotypic correlations. RSM showed that increased serum concentrations of α- and β-carotenoids rather than that of β-cryptoxanthin or lycopene had maximal effects on ISI. In summary, our findings suggest that the serum carotenoids are under strong additive genetic influences and may have differential effects on susceptibility to CMTs in children.https://doi.org/10.1038/s41598-020-79387-8 |
| spellingShingle | Srinivas Mummidi Vidya S. Farook Lavanya Reddivari Joselin Hernandez-Ruiz Alvaro Diaz-Badillo Sharon P. Fowler Roy G. Resendez Feroz Akhtar Donna M. Lehman Christopher P. Jenkinson Rector Arya Jane L. Lynch Jose A. Canas Ralph A. DeFronzo Daniel E. Hale John Blangero Juan Carlos Lopez-Alvarenga Ravindranath Duggirala Jairam K. P. Vanamala Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children Scientific Reports |
| title | Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children |
| title_full | Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children |
| title_fullStr | Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children |
| title_full_unstemmed | Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children |
| title_short | Serum carotenoids and Pediatric Metabolic Index predict insulin sensitivity in Mexican American children |
| title_sort | serum carotenoids and pediatric metabolic index predict insulin sensitivity in mexican american children |
| url | https://doi.org/10.1038/s41598-020-79387-8 |
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