A Bionic Self-Assembly Hydrogel Constructed by Peptides With Favorable Biosecurity, Rapid Hemostasis and Antibacterial Property for Wound Healing
Bionic self-assembly hydrogel derived by peptide as an effective biomedical hemostatic agent has always gained great attention. However, developing hydrogels with eminent-biosecurity, rapidly hemostatic and bactericidal function remains a critical challenge. Hence, we designed an injectable hydrogel...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.901534/full |
| _version_ | 1811238012208545792 |
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| author | Yang Wang Yang Wang Xiao Li Juzheng Yuan Xudan Wang Kaishan Tao Jin Yan Jin Yan |
| author_facet | Yang Wang Yang Wang Xiao Li Juzheng Yuan Xudan Wang Kaishan Tao Jin Yan Jin Yan |
| author_sort | Yang Wang |
| collection | DOAJ |
| description | Bionic self-assembly hydrogel derived by peptide as an effective biomedical hemostatic agent has always gained great attention. However, developing hydrogels with eminent-biosecurity, rapidly hemostatic and bactericidal function remains a critical challenge. Hence, we designed an injectable hydrogel with hemostatic and bactericidal function based on Bionic Self-Assembling Peptide (BSAP) in this study. BSAP was formed with two functionalized peptides containing (RADA)4 motif and possessed the ability to self-assemble into nanofibers. As expected, BSAP could rapidly co-assemble into hydrogel network structure in situ driven by Ca2+. The hydrogel with a concentration of 5% showed a superior microporous structure and excellent shear thinning characteristics, as well as injectability. Moreover, in the foot trauma model and tail amputation model, the fabricated hydrogel exhibited a lower blood clotting index and dramatically reduced blood clotting time and bleeding volume. Remarkably, the hydrogel reduced inflammatory responses by blocking bacterial infection, promoting wound healing. Finally, the hydrogel is highly hemocompatible and has no cytotoxicity. Overall, this work provides a strategy for developing a high-biosecurity hydrogel with hemostatic and antibacterial properties, which will allow for the clinical application of BSAP. |
| first_indexed | 2024-04-12T12:34:26Z |
| format | Article |
| id | doaj.art-9ea3529fa6974250b34f1ff8c31a9581 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T12:34:26Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-9ea3529fa6974250b34f1ff8c31a95812022-12-22T03:32:56ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-06-011010.3389/fbioe.2022.901534901534A Bionic Self-Assembly Hydrogel Constructed by Peptides With Favorable Biosecurity, Rapid Hemostasis and Antibacterial Property for Wound HealingYang Wang0Yang Wang1Xiao Li2Juzheng Yuan3Xudan Wang4Kaishan Tao5Jin Yan6Jin Yan7National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Tumor and Immunology in Precision Medical Institute, Western China Science and Technology Innovation Port, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaDepartment of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, ChinaNational and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, ChinaDepartment of Tumor and Immunology in Precision Medical Institute, Western China Science and Technology Innovation Port, Xi’an, ChinaBionic self-assembly hydrogel derived by peptide as an effective biomedical hemostatic agent has always gained great attention. However, developing hydrogels with eminent-biosecurity, rapidly hemostatic and bactericidal function remains a critical challenge. Hence, we designed an injectable hydrogel with hemostatic and bactericidal function based on Bionic Self-Assembling Peptide (BSAP) in this study. BSAP was formed with two functionalized peptides containing (RADA)4 motif and possessed the ability to self-assemble into nanofibers. As expected, BSAP could rapidly co-assemble into hydrogel network structure in situ driven by Ca2+. The hydrogel with a concentration of 5% showed a superior microporous structure and excellent shear thinning characteristics, as well as injectability. Moreover, in the foot trauma model and tail amputation model, the fabricated hydrogel exhibited a lower blood clotting index and dramatically reduced blood clotting time and bleeding volume. Remarkably, the hydrogel reduced inflammatory responses by blocking bacterial infection, promoting wound healing. Finally, the hydrogel is highly hemocompatible and has no cytotoxicity. Overall, this work provides a strategy for developing a high-biosecurity hydrogel with hemostatic and antibacterial properties, which will allow for the clinical application of BSAP.https://www.frontiersin.org/articles/10.3389/fbioe.2022.901534/fullpeptidehydrogelself-assemblyhemostasisantibacterial |
| spellingShingle | Yang Wang Yang Wang Xiao Li Juzheng Yuan Xudan Wang Kaishan Tao Jin Yan Jin Yan A Bionic Self-Assembly Hydrogel Constructed by Peptides With Favorable Biosecurity, Rapid Hemostasis and Antibacterial Property for Wound Healing Frontiers in Bioengineering and Biotechnology peptide hydrogel self-assembly hemostasis antibacterial |
| title | A Bionic Self-Assembly Hydrogel Constructed by Peptides With Favorable Biosecurity, Rapid Hemostasis and Antibacterial Property for Wound Healing |
| title_full | A Bionic Self-Assembly Hydrogel Constructed by Peptides With Favorable Biosecurity, Rapid Hemostasis and Antibacterial Property for Wound Healing |
| title_fullStr | A Bionic Self-Assembly Hydrogel Constructed by Peptides With Favorable Biosecurity, Rapid Hemostasis and Antibacterial Property for Wound Healing |
| title_full_unstemmed | A Bionic Self-Assembly Hydrogel Constructed by Peptides With Favorable Biosecurity, Rapid Hemostasis and Antibacterial Property for Wound Healing |
| title_short | A Bionic Self-Assembly Hydrogel Constructed by Peptides With Favorable Biosecurity, Rapid Hemostasis and Antibacterial Property for Wound Healing |
| title_sort | bionic self assembly hydrogel constructed by peptides with favorable biosecurity rapid hemostasis and antibacterial property for wound healing |
| topic | peptide hydrogel self-assembly hemostasis antibacterial |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.901534/full |
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