Therapeutic potential of Hsp27 in neurological diseases
Abstract Background Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and non-stress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily. The function of Hsps in neurodegenerative disorders is puzzling an...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2019-11-01
|
| Series: | Egyptian Journal of Medical Human Genetics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s43042-019-0023-4 |
| _version_ | 1828553685773320192 |
|---|---|
| author | Anila Venugopal Kasthuri Sundaramoorthy Balachandar Vellingiri |
| author_facet | Anila Venugopal Kasthuri Sundaramoorthy Balachandar Vellingiri |
| author_sort | Anila Venugopal |
| collection | DOAJ |
| description | Abstract Background Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and non-stress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily. The function of Hsps in neurodegenerative disorders is puzzling and not fully understood. This review aims to focus on the role of Hsp27 in normal and diseased conditions and emphasize its therapeutic potential. Hsp27 Hsp27, in particular, has shown to be involved in cell viability and actin cytoskeleton remodeling and also shown to improve many disease conditions. Phosphorylated Hsp27 modulates the p53 pathway by downregulating cellular senescence and also lowers reactive oxygen species to protect TNFα-mediated apoptosis. Hsp27 is also known to interfere with mitochondria-dependent and mitochondria-independent cell apoptotic stimulation. Conclusion This article will highlight the various functions of Hsp27 especially as an anti-apoptotic factor and stress response factor and its therapeutic potential in preventing neuronal apoptosis in neurological diseases. This review also includes a comparison of the therapeutic potential of Hsp27 with regard to other small Hsps. |
| first_indexed | 2024-12-12T05:22:55Z |
| format | Article |
| id | doaj.art-9ea36dd25b914c6dac61b1ce189cc2f4 |
| institution | Directory Open Access Journal |
| issn | 2090-2441 |
| language | English |
| last_indexed | 2024-12-12T05:22:55Z |
| publishDate | 2019-11-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj.art-9ea36dd25b914c6dac61b1ce189cc2f42022-12-22T00:36:35ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412019-11-012011810.1186/s43042-019-0023-4Therapeutic potential of Hsp27 in neurological diseasesAnila Venugopal0Kasthuri Sundaramoorthy1Balachandar Vellingiri2Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar UniversitySchool of Biotechnology, Madurai Kamaraj UniversityHuman Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar UniversityAbstract Background Heat shock proteins (Hsps) are widely reported in normal cellular dynamics under stress and non-stress conditions, and parallelly, the studies regarding its role in disease condition are also progressing steadily. The function of Hsps in neurodegenerative disorders is puzzling and not fully understood. This review aims to focus on the role of Hsp27 in normal and diseased conditions and emphasize its therapeutic potential. Hsp27 Hsp27, in particular, has shown to be involved in cell viability and actin cytoskeleton remodeling and also shown to improve many disease conditions. Phosphorylated Hsp27 modulates the p53 pathway by downregulating cellular senescence and also lowers reactive oxygen species to protect TNFα-mediated apoptosis. Hsp27 is also known to interfere with mitochondria-dependent and mitochondria-independent cell apoptotic stimulation. Conclusion This article will highlight the various functions of Hsp27 especially as an anti-apoptotic factor and stress response factor and its therapeutic potential in preventing neuronal apoptosis in neurological diseases. This review also includes a comparison of the therapeutic potential of Hsp27 with regard to other small Hsps.http://link.springer.com/article/10.1186/s43042-019-0023-4Heat shock proteinsHsp27Neurological diseasesTherapeutic |
| spellingShingle | Anila Venugopal Kasthuri Sundaramoorthy Balachandar Vellingiri Therapeutic potential of Hsp27 in neurological diseases Egyptian Journal of Medical Human Genetics Heat shock proteins Hsp27 Neurological diseases Therapeutic |
| title | Therapeutic potential of Hsp27 in neurological diseases |
| title_full | Therapeutic potential of Hsp27 in neurological diseases |
| title_fullStr | Therapeutic potential of Hsp27 in neurological diseases |
| title_full_unstemmed | Therapeutic potential of Hsp27 in neurological diseases |
| title_short | Therapeutic potential of Hsp27 in neurological diseases |
| title_sort | therapeutic potential of hsp27 in neurological diseases |
| topic | Heat shock proteins Hsp27 Neurological diseases Therapeutic |
| url | http://link.springer.com/article/10.1186/s43042-019-0023-4 |
| work_keys_str_mv | AT anilavenugopal therapeuticpotentialofhsp27inneurologicaldiseases AT kasthurisundaramoorthy therapeuticpotentialofhsp27inneurologicaldiseases AT balachandarvellingiri therapeuticpotentialofhsp27inneurologicaldiseases |