APOPTOSIS IN ORAL DIAGNOSTICS: AN OVERVIEW
Apoptosis describes the molecular and morphological processes leading to controlled cellular self destruction. In recent years, it has been investigated for its biological significance in numerous physiological processes including embryogenesis, differentiation, proliferation /homeostasis and in th...
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| Format: | Article |
| Language: | English |
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Dow University of Health Sciences
2009-01-01
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| Series: | Journal of the Dow University of Health Sciences |
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| Online Access: | https://www.jduhs.com/index.php/jduhs/article/view/1305 |
| _version_ | 1797817581694877696 |
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| author | Amynah Shaikh Sadiqa Syed Masood A Qureshi |
| author_facet | Amynah Shaikh Sadiqa Syed Masood A Qureshi |
| author_sort | Amynah Shaikh |
| collection | DOAJ |
| description |
Apoptosis describes the molecular and morphological processes leading to controlled cellular self destruction. In recent years, it has been investigated for its biological significance in numerous physiological processes including embryogenesis, differentiation, proliferation /homeostasis and in the regulation of immune system. Its dysfunction and deregulation seems responsible for variety of pathological conditions e.g immune deficiency, autoimmune diseases, neuro-degenerative diseases and cancer. This communication updates molecular understanding of this natural phenomenon and its application in oral diagnostics. The present concept of signaling pathways for initiation of apoptotic characteristic changes is illu stra te d and the ro le o f certain ap o p to tic genes id e n tifie d so far is discu ssed. Abnormality of apoptosis and apoptotic regulatory genes during oral carcinogenesis, though conflictory, is presented. Further, clinical potential for monitoring reactions to chemo-radiotherapy is evaluated from human and animal studies and their usage as physiological markers for oral preneoplasia and squamous cell
carcinoma is analyzed. On the basis of oral cytology the application of new physical and molecular methodological techniques is
outlined e.g cytophotometry, DNA cytometry in relation to molecular studies and their diagnostic and
prognostic implications. Understanding of molecular mechanisms provides development of newer therapeutic approaches in disease management and in future biomedical research. This overview updates molecular understanding of this
natural phenomenon as its applications seem to have potential for managing common diseases in future.
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| first_indexed | 2024-03-13T08:55:37Z |
| format | Article |
| id | doaj.art-9ea40deb20934d4d917719f81be0566e |
| institution | Directory Open Access Journal |
| issn | 1995-2198 2410-2180 |
| language | English |
| last_indexed | 2024-03-13T08:55:37Z |
| publishDate | 2009-01-01 |
| publisher | Dow University of Health Sciences |
| record_format | Article |
| series | Journal of the Dow University of Health Sciences |
| spelling | doaj.art-9ea40deb20934d4d917719f81be0566e2023-05-29T03:12:01ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802009-01-0131APOPTOSIS IN ORAL DIAGNOSTICS: AN OVERVIEWAmynah ShaikhSadiqa SyedMasood A Qureshi Apoptosis describes the molecular and morphological processes leading to controlled cellular self destruction. In recent years, it has been investigated for its biological significance in numerous physiological processes including embryogenesis, differentiation, proliferation /homeostasis and in the regulation of immune system. Its dysfunction and deregulation seems responsible for variety of pathological conditions e.g immune deficiency, autoimmune diseases, neuro-degenerative diseases and cancer. This communication updates molecular understanding of this natural phenomenon and its application in oral diagnostics. The present concept of signaling pathways for initiation of apoptotic characteristic changes is illu stra te d and the ro le o f certain ap o p to tic genes id e n tifie d so far is discu ssed. Abnormality of apoptosis and apoptotic regulatory genes during oral carcinogenesis, though conflictory, is presented. Further, clinical potential for monitoring reactions to chemo-radiotherapy is evaluated from human and animal studies and their usage as physiological markers for oral preneoplasia and squamous cell carcinoma is analyzed. On the basis of oral cytology the application of new physical and molecular methodological techniques is outlined e.g cytophotometry, DNA cytometry in relation to molecular studies and their diagnostic and prognostic implications. Understanding of molecular mechanisms provides development of newer therapeutic approaches in disease management and in future biomedical research. This overview updates molecular understanding of this natural phenomenon as its applications seem to have potential for managing common diseases in future. https://www.jduhs.com/index.php/jduhs/article/view/1305Apoptosiscell deathoral mucosa |
| spellingShingle | Amynah Shaikh Sadiqa Syed Masood A Qureshi APOPTOSIS IN ORAL DIAGNOSTICS: AN OVERVIEW Journal of the Dow University of Health Sciences Apoptosis cell death oral mucosa |
| title | APOPTOSIS IN ORAL DIAGNOSTICS: AN OVERVIEW |
| title_full | APOPTOSIS IN ORAL DIAGNOSTICS: AN OVERVIEW |
| title_fullStr | APOPTOSIS IN ORAL DIAGNOSTICS: AN OVERVIEW |
| title_full_unstemmed | APOPTOSIS IN ORAL DIAGNOSTICS: AN OVERVIEW |
| title_short | APOPTOSIS IN ORAL DIAGNOSTICS: AN OVERVIEW |
| title_sort | apoptosis in oral diagnostics an overview |
| topic | Apoptosis cell death oral mucosa |
| url | https://www.jduhs.com/index.php/jduhs/article/view/1305 |
| work_keys_str_mv | AT amynahshaikh apoptosisinoraldiagnosticsanoverview AT sadiqasyed apoptosisinoraldiagnosticsanoverview AT masoodaqureshi apoptosisinoraldiagnosticsanoverview |