Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation
Key Clinical Message Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several days of treatment. When anticoagulation therapy is...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.7284 |
| _version_ | 1797791754689183744 |
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| author | Marlena Frydrysiak Paulina Pachniak Anna Krysicka Dariusz Moczulski |
| author_facet | Marlena Frydrysiak Paulina Pachniak Anna Krysicka Dariusz Moczulski |
| author_sort | Marlena Frydrysiak |
| collection | DOAJ |
| description | Key Clinical Message Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several days of treatment. When anticoagulation therapy is needed vitamin K antagonist are a good option for the initial treatment. Abstract Lupus anticoagulant antibodies despite causing aPTT prolongation are commonly associated with increased risk of thrombosis. We present a rare case of patient when these autoantibodies resulted in dramatic aPTT prolongation and combined with associated thrombocytopenia resulted in minor bleeding events. In presented case treatment with oral steroids resulted in aPTT values correction followed by resolution of bleeding tendency within several days. Later, the patient developed chronic atrial fibrillation and was started on anticoagulation treatment initially with vitamin K antagonist without bleeding complications during follow‐up period. Corresponding changes in patient's aPTT time in a course of whole treatment is presented. |
| first_indexed | 2024-03-13T02:23:16Z |
| format | Article |
| id | doaj.art-9ea47681e6db4912b859d945059555e8 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-03-13T02:23:16Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-9ea47681e6db4912b859d945059555e82023-06-30T07:34:07ZengWileyClinical Case Reports2050-09042023-06-01116n/an/a10.1002/ccr3.7284Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillationMarlena Frydrysiak0Paulina Pachniak1Anna Krysicka2Dariusz Moczulski3Department of Internal Medicine and Nephrodiabetology Medical University of Lodz Lodz PolandDepartment of Internal Medicine and Nephrodiabetology Medical University of Lodz Lodz PolandDepartment of Internal Medicine and Nephrodiabetology Medical University of Lodz Lodz PolandDepartment of Internal Medicine and Nephrodiabetology Medical University of Lodz Lodz PolandKey Clinical Message Lupus anticoagulant caused aPTT prolongation in rare case can cause bleeding tendency especially when combined with other hemostasis abnormalities. In such cases, aPTT value can be corrected by immunosuppressants within several days of treatment. When anticoagulation therapy is needed vitamin K antagonist are a good option for the initial treatment. Abstract Lupus anticoagulant antibodies despite causing aPTT prolongation are commonly associated with increased risk of thrombosis. We present a rare case of patient when these autoantibodies resulted in dramatic aPTT prolongation and combined with associated thrombocytopenia resulted in minor bleeding events. In presented case treatment with oral steroids resulted in aPTT values correction followed by resolution of bleeding tendency within several days. Later, the patient developed chronic atrial fibrillation and was started on anticoagulation treatment initially with vitamin K antagonist without bleeding complications during follow‐up period. Corresponding changes in patient's aPTT time in a course of whole treatment is presented.https://doi.org/10.1002/ccr3.7284aPTT prolongationbleedingcase reportlupus anticoagulant |
| spellingShingle | Marlena Frydrysiak Paulina Pachniak Anna Krysicka Dariusz Moczulski Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation Clinical Case Reports aPTT prolongation bleeding case report lupus anticoagulant |
| title | Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
| title_full | Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
| title_fullStr | Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
| title_full_unstemmed | Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
| title_short | Patient with lupus anticoagulant caused aPTT prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
| title_sort | patient with lupus anticoagulant caused aptt prolongation corrected with prednisolone treatment and later anticoagulation treatment due to chronic atrial fibrillation |
| topic | aPTT prolongation bleeding case report lupus anticoagulant |
| url | https://doi.org/10.1002/ccr3.7284 |
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