Combining NMR Spectroscopy and Chemometrics to Monitor Structural Features of Crude Hep-arin

Combining NMR Spectroscopy and Chemometrics to Monitor Structural Features of Crude Hep-arin

Because of the complexity and global nature of the heparin supply chain, the control of heparin quality during manufacturing steps is essential to ensure the safety of the final active pharmaceutical ingredient (API). For this reason, there is a need to develop consistent analytical methods able to...

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Bibliographic Details
Main Authors: Lucio Mauri, Maria Marinozzi, Giulia Mazzini, Richard E. Kolinski, Michael Karfunkle, David A. Keire, Marco Guerrini
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Molecules
Subjects:
heparin
crude heparin
NMR
quantitative NMR
PCA
chemometric
HSQC
Online Access:https://www.mdpi.com/1420-3049/22/7/1146

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