Comprehensive Case–Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia
To examine protective and risk factors for Buruli ulcer (BU), we conducted a case–control study of 245 adult BU cases and 481 postcode-matched controls across BU-endemic areas of Victoria, Australia. We calculated age- and sex-adjusted odds ratios for socio-environmental, host, and behavioral facto...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2023-10-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/29/10/23-0011_article |
| _version_ | 1797678570591485952 |
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| author | Bridgette J. McNamara Kim R. Blasdell Arvind Yerramilli Ina L. Smith Simone L. Clayton Michael Dunn Ee Laine Tay Katherine B. Gibney Nilakshi T. Waidyatillake Mohammad A. Hussain Michael Muleme Daniel P. O’Brien Eugene Athan |
| author_facet | Bridgette J. McNamara Kim R. Blasdell Arvind Yerramilli Ina L. Smith Simone L. Clayton Michael Dunn Ee Laine Tay Katherine B. Gibney Nilakshi T. Waidyatillake Mohammad A. Hussain Michael Muleme Daniel P. O’Brien Eugene Athan |
| author_sort | Bridgette J. McNamara |
| collection | DOAJ |
| description |
To examine protective and risk factors for Buruli ulcer (BU), we conducted a case–control study of 245 adult BU cases and 481 postcode-matched controls across BU-endemic areas of Victoria, Australia. We calculated age- and sex-adjusted odds ratios for socio-environmental, host, and behavioral factors associated with BU by using conditional logistic regression. Odds of BU were >2-fold for persons with diabetes mellitus and persons working outdoors who had soil contact in BU-endemic areas (compared with indoor work) but were lower among persons who had bacillus Calmette–Guérin vaccinations. BU was associated with increasing numbers of possums and with ponds and bore water use at residences. Using insect repellent, covering arms and legs outdoors, and immediately washing wounds were protective; undertaking multiple protective behaviors was associated with the lowest odds of BU. Skin hygiene/protection behaviors and previous bacillus Calmette–Guérin vaccination might provide protection against BU in BU-endemic areas.
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| first_indexed | 2024-03-11T23:01:52Z |
| format | Article |
| id | doaj.art-9ea54c69fdfa400a99520492e7ebacc1 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-03-11T23:01:52Z |
| publishDate | 2023-10-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-9ea54c69fdfa400a99520492e7ebacc12023-09-21T14:51:59ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592023-10-0129102032204310.3201/eid2910.230011Comprehensive Case–Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern AustraliaBridgette J. McNamaraKim R. BlasdellArvind YerramilliIna L. SmithSimone L. ClaytonMichael DunnEe Laine TayKatherine B. GibneyNilakshi T. WaidyatillakeMohammad A. HussainMichael MulemeDaniel P. O’BrienEugene Athan To examine protective and risk factors for Buruli ulcer (BU), we conducted a case–control study of 245 adult BU cases and 481 postcode-matched controls across BU-endemic areas of Victoria, Australia. We calculated age- and sex-adjusted odds ratios for socio-environmental, host, and behavioral factors associated with BU by using conditional logistic regression. Odds of BU were >2-fold for persons with diabetes mellitus and persons working outdoors who had soil contact in BU-endemic areas (compared with indoor work) but were lower among persons who had bacillus Calmette–Guérin vaccinations. BU was associated with increasing numbers of possums and with ponds and bore water use at residences. Using insect repellent, covering arms and legs outdoors, and immediately washing wounds were protective; undertaking multiple protective behaviors was associated with the lowest odds of BU. Skin hygiene/protection behaviors and previous bacillus Calmette–Guérin vaccination might provide protection against BU in BU-endemic areas. https://wwwnc.cdc.gov/eid/article/29/10/23-0011_articleBuruli ulcerMycobacterium ulceransMycobacteriumrisk factorsprotective factorscase-control studies |
| spellingShingle | Bridgette J. McNamara Kim R. Blasdell Arvind Yerramilli Ina L. Smith Simone L. Clayton Michael Dunn Ee Laine Tay Katherine B. Gibney Nilakshi T. Waidyatillake Mohammad A. Hussain Michael Muleme Daniel P. O’Brien Eugene Athan Comprehensive Case–Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia Emerging Infectious Diseases Buruli ulcer Mycobacterium ulcerans Mycobacterium risk factors protective factors case-control studies |
| title | Comprehensive Case–Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia |
| title_full | Comprehensive Case–Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia |
| title_fullStr | Comprehensive Case–Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia |
| title_full_unstemmed | Comprehensive Case–Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia |
| title_short | Comprehensive Case–Control Study of Protective and Risk Factors for Buruli Ulcer, Southeastern Australia |
| title_sort | comprehensive case control study of protective and risk factors for buruli ulcer southeastern australia |
| topic | Buruli ulcer Mycobacterium ulcerans Mycobacterium risk factors protective factors case-control studies |
| url | https://wwwnc.cdc.gov/eid/article/29/10/23-0011_article |
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