TRIM32: A Multifunctional Protein Involved in Muscle Homeostasis, Glucose Metabolism, and Tumorigenesis
Human tripartite motif family of proteins 32 (TRIM32) is a ubiquitous multifunctional protein that has demonstrated roles in differentiation, muscle physiology and regeneration, and tumor suppression. Mutations in TRIM32 result in two clinically diverse diseases. A mutation in the B-box domain gives...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/3/408 |
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| author | Simranjot Bawa Rosanna Piccirillo Erika R. Geisbrecht |
| author_facet | Simranjot Bawa Rosanna Piccirillo Erika R. Geisbrecht |
| author_sort | Simranjot Bawa |
| collection | DOAJ |
| description | Human tripartite motif family of proteins 32 (TRIM32) is a ubiquitous multifunctional protein that has demonstrated roles in differentiation, muscle physiology and regeneration, and tumor suppression. Mutations in TRIM32 result in two clinically diverse diseases. A mutation in the B-box domain gives rise to Bardet–Biedl syndrome (BBS), a disease whose clinical presentation shares no muscle pathology, while mutations in the NHL (NCL-1, HT2A, LIN-41) repeats of TRIM32 causes limb-girdle muscular dystrophy type 2H (LGMD2H). TRIM32 also functions as a tumor suppressor, but paradoxically is overexpressed in certain types of cancer. Recent evidence supports a role for TRIM32 in glycolytic-mediated cell growth, thus providing a possible mechanism for TRIM32 in the accumulation of cellular biomass during regeneration and tumorigenesis, including in vitro and in vivo approaches, to understand the broad spectrum of TRIM32 functions. A special emphasis is placed on the utility of the <i>Drosophila</i> model, a unique system to study glycolysis and anabolic pathways that contribute to the growth and homeostasis of both normal and tumor tissues. |
| first_indexed | 2024-03-10T13:22:31Z |
| format | Article |
| id | doaj.art-9ea5d533a1ef4506b65cd23f1b740ace |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T13:22:31Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-9ea5d533a1ef4506b65cd23f1b740ace2023-11-21T09:55:54ZengMDPI AGBiomolecules2218-273X2021-03-0111340810.3390/biom11030408TRIM32: A Multifunctional Protein Involved in Muscle Homeostasis, Glucose Metabolism, and TumorigenesisSimranjot Bawa0Rosanna Piccirillo1Erika R. Geisbrecht2Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USADepartment of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, ItalyDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS 66506, USAHuman tripartite motif family of proteins 32 (TRIM32) is a ubiquitous multifunctional protein that has demonstrated roles in differentiation, muscle physiology and regeneration, and tumor suppression. Mutations in TRIM32 result in two clinically diverse diseases. A mutation in the B-box domain gives rise to Bardet–Biedl syndrome (BBS), a disease whose clinical presentation shares no muscle pathology, while mutations in the NHL (NCL-1, HT2A, LIN-41) repeats of TRIM32 causes limb-girdle muscular dystrophy type 2H (LGMD2H). TRIM32 also functions as a tumor suppressor, but paradoxically is overexpressed in certain types of cancer. Recent evidence supports a role for TRIM32 in glycolytic-mediated cell growth, thus providing a possible mechanism for TRIM32 in the accumulation of cellular biomass during regeneration and tumorigenesis, including in vitro and in vivo approaches, to understand the broad spectrum of TRIM32 functions. A special emphasis is placed on the utility of the <i>Drosophila</i> model, a unique system to study glycolysis and anabolic pathways that contribute to the growth and homeostasis of both normal and tumor tissues.https://www.mdpi.com/2218-273X/11/3/408musclecostameremuscular dystrophycancer |
| spellingShingle | Simranjot Bawa Rosanna Piccirillo Erika R. Geisbrecht TRIM32: A Multifunctional Protein Involved in Muscle Homeostasis, Glucose Metabolism, and Tumorigenesis Biomolecules muscle costamere muscular dystrophy cancer |
| title | TRIM32: A Multifunctional Protein Involved in Muscle Homeostasis, Glucose Metabolism, and Tumorigenesis |
| title_full | TRIM32: A Multifunctional Protein Involved in Muscle Homeostasis, Glucose Metabolism, and Tumorigenesis |
| title_fullStr | TRIM32: A Multifunctional Protein Involved in Muscle Homeostasis, Glucose Metabolism, and Tumorigenesis |
| title_full_unstemmed | TRIM32: A Multifunctional Protein Involved in Muscle Homeostasis, Glucose Metabolism, and Tumorigenesis |
| title_short | TRIM32: A Multifunctional Protein Involved in Muscle Homeostasis, Glucose Metabolism, and Tumorigenesis |
| title_sort | trim32 a multifunctional protein involved in muscle homeostasis glucose metabolism and tumorigenesis |
| topic | muscle costamere muscular dystrophy cancer |
| url | https://www.mdpi.com/2218-273X/11/3/408 |
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