Deletion of PRAK Mitigates the Mitochondria Function and Suppresses Insulin Signaling in C2C12 Myoblasts Exposed to High Glucose

Deletion of PRAK Mitigates the Mitochondria Function and Suppresses Insulin Signaling in C2C12 Myoblasts Exposed to High Glucose

Background: p38 regulated/activated protein kinase (PRAK) plays a crucial role in modulating cell death and survival. However, the role of PRAK in the regulation of metabolic stress remains unclear. We examined the effects of PRAK on cell survival and mitochondrial function in C2C12 myoblasts in res...

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Bibliographic Details
Main Authors: Ling Zhang, Jianguo Wang, Yu Tina Zhao, Patrycja Dubielecka, Gangjian Qin, Shougang Zhuang, Eugene Y Chin, Paul Y Liu, Ting C Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
C2C12 myoblasts
metabolic stress
mitochondria
high glucose
insulin signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.698714/full

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