Improving the models for prognosis of aneurysmal subarachnoid hemorrhage with the neutrophil-to-albumin ratio
ObjectiveMany peripheral inflammatory markers were reported to be associated with the prognosis of aneurysmal subarachnoid hemorrhage (aSAH). We aimed to identify the most promising inflammatory factor that can improve existing predictive models.MethodsThe study was based on data from a 10 year retr...
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| Format: | Article |
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2023.1078926/full |
| _version_ | 1797861031169490944 |
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| author | Renjie Zhang Zheran Liu Yu Zhang Yiyan Pei Yan He Jiayi Yu Chao You Lu Ma Fang Fang |
| author_facet | Renjie Zhang Zheran Liu Yu Zhang Yiyan Pei Yan He Jiayi Yu Chao You Lu Ma Fang Fang |
| author_sort | Renjie Zhang |
| collection | DOAJ |
| description | ObjectiveMany peripheral inflammatory markers were reported to be associated with the prognosis of aneurysmal subarachnoid hemorrhage (aSAH). We aimed to identify the most promising inflammatory factor that can improve existing predictive models.MethodsThe study was based on data from a 10 year retrospective cohort study at Sichuan University West China Hospital. We selected the well-known SAFIRE and Subarachnoid Hemorrhage International Trialists’ (SAHIT) models as the basic models. We compared the performance of the models after including the inflammatory markers and that of the original models. The developed models were internally and temporally validated.ResultsA total of 3,173 patients were included in this study, divided into the derivation cohort (n = 2,525) and the validation cohort (n = 648). Most inflammatory markers could improve the SAH model for mortality prediction in patients with aSAH, and the neutrophil-to-albumin ratio (NAR) performed best among all the included inflammatory markers. By incorporating NAR, the modified SAFIRE and SAHIT models improved the area under the receiver operator characteristics curve (SAFIRE+NAR vs. SAFIRE: 0.794 vs. 0.778, p = 0.012; SAHIT+NAR vs. SAHIT: 0.831 vs. 0.819, p = 0.016) and categorical net reclassification improvement (SAFIRE+NAR: 0.0727, p = 0.002; SAHIT+NAR: 0.0810, p < 0.001).ConclusionThis study illustrated that among the inflammatory markers associated with aSAH prognosis, NAR could improve the SAFIRE and SAHIT models for 3 month mortality of aSAH. |
| first_indexed | 2024-04-09T21:56:37Z |
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| id | doaj.art-9ea7c596a41a4ddf832d375a217313e6 |
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| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-09T21:56:37Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-9ea7c596a41a4ddf832d375a217313e62023-03-24T05:28:04ZengFrontiers Media S.A.Frontiers in Neurology1664-22952023-03-011410.3389/fneur.2023.10789261078926Improving the models for prognosis of aneurysmal subarachnoid hemorrhage with the neutrophil-to-albumin ratioRenjie Zhang0Zheran Liu1Yu Zhang2Yiyan Pei3Yan He4Jiayi Yu5Chao You6Lu Ma7Fang Fang8Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaCenter for Evidence-Based Medical and Clinical Research, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Biotherapy, Cancer Center, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan, ChinaObjectiveMany peripheral inflammatory markers were reported to be associated with the prognosis of aneurysmal subarachnoid hemorrhage (aSAH). We aimed to identify the most promising inflammatory factor that can improve existing predictive models.MethodsThe study was based on data from a 10 year retrospective cohort study at Sichuan University West China Hospital. We selected the well-known SAFIRE and Subarachnoid Hemorrhage International Trialists’ (SAHIT) models as the basic models. We compared the performance of the models after including the inflammatory markers and that of the original models. The developed models were internally and temporally validated.ResultsA total of 3,173 patients were included in this study, divided into the derivation cohort (n = 2,525) and the validation cohort (n = 648). Most inflammatory markers could improve the SAH model for mortality prediction in patients with aSAH, and the neutrophil-to-albumin ratio (NAR) performed best among all the included inflammatory markers. By incorporating NAR, the modified SAFIRE and SAHIT models improved the area under the receiver operator characteristics curve (SAFIRE+NAR vs. SAFIRE: 0.794 vs. 0.778, p = 0.012; SAHIT+NAR vs. SAHIT: 0.831 vs. 0.819, p = 0.016) and categorical net reclassification improvement (SAFIRE+NAR: 0.0727, p = 0.002; SAHIT+NAR: 0.0810, p < 0.001).ConclusionThis study illustrated that among the inflammatory markers associated with aSAH prognosis, NAR could improve the SAFIRE and SAHIT models for 3 month mortality of aSAH.https://www.frontiersin.org/articles/10.3389/fneur.2023.1078926/fullneutrophil-to-albumin ratiointracranial aneurysmsubarachnoid hemorrhagemortalityprediction model |
| spellingShingle | Renjie Zhang Zheran Liu Yu Zhang Yiyan Pei Yan He Jiayi Yu Chao You Lu Ma Fang Fang Improving the models for prognosis of aneurysmal subarachnoid hemorrhage with the neutrophil-to-albumin ratio Frontiers in Neurology neutrophil-to-albumin ratio intracranial aneurysm subarachnoid hemorrhage mortality prediction model |
| title | Improving the models for prognosis of aneurysmal subarachnoid hemorrhage with the neutrophil-to-albumin ratio |
| title_full | Improving the models for prognosis of aneurysmal subarachnoid hemorrhage with the neutrophil-to-albumin ratio |
| title_fullStr | Improving the models for prognosis of aneurysmal subarachnoid hemorrhage with the neutrophil-to-albumin ratio |
| title_full_unstemmed | Improving the models for prognosis of aneurysmal subarachnoid hemorrhage with the neutrophil-to-albumin ratio |
| title_short | Improving the models for prognosis of aneurysmal subarachnoid hemorrhage with the neutrophil-to-albumin ratio |
| title_sort | improving the models for prognosis of aneurysmal subarachnoid hemorrhage with the neutrophil to albumin ratio |
| topic | neutrophil-to-albumin ratio intracranial aneurysm subarachnoid hemorrhage mortality prediction model |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2023.1078926/full |
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