Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus.
Background: There is a general acceptance which illustrated that auto antibodies act as a central immunological disturbance in most of the auto immune diseases, among these auto immune diseaselies the SLE Patients and Methods: Thirty five patients with SLE were compared to twenty age and sex matched...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2010-01-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1097 |
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| author | Sajid N. Abdualkader Abdul- Wahab Al-Shaikly Khalida M. Al-Mousawy Mustafa Al-Ezzi Maan G. Hasso Zena E. Hassan |
| author_facet | Sajid N. Abdualkader Abdul- Wahab Al-Shaikly Khalida M. Al-Mousawy Mustafa Al-Ezzi Maan G. Hasso Zena E. Hassan |
| author_sort | Sajid N. Abdualkader |
| collection | DOAJ |
| description | Background: There is a general acceptance which illustrated that auto antibodies act as a central immunological disturbance in most of the auto immune diseases, among these auto immune diseaselies the SLE
Patients and Methods: Thirty five patients with SLE were compared to twenty age and sex matched, control subjects and studied for the presence of auto antibodies, plus IL-4 and IL-6 using Elisa method and immune fluorescent method (for ANA only)
Results: Data showed that IL-6 detectable levels were statistically significant in patients with positive anti ds-DNA, but not significant statistically in ANA positive patients although it was detected in 24 (70.6%) of positive ANA patients, while there was no statistically significant correlation between IL- 4 detectable level and autoantibodies production.
Conclusion: There is apparently a positive correlation between IL-6 and anti ds DNA production in lupus patients. |
| first_indexed | 2024-03-08T17:53:28Z |
| format | Article |
| id | doaj.art-9eaa37d3a9964652b5fe4f26005e9537 |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:53:28Z |
| publishDate | 2010-01-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-9eaa37d3a9964652b5fe4f26005e95372024-01-02T06:49:09ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572010-01-0151410.32007/jfacmedbagdad.v4416-418%Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus.Sajid N. Abdualkader0Abdul- Wahab Al-Shaikly1Khalida M. Al-Mousawy2Mustafa Al-Ezzi3Maan G. Hasso4Zena E. Hassan5Teaching Laboratories, Medical city (Clinical Immunology.Dept. of Microbiology-Al-Kindi College of Medicine (Clinical Immunology)Dept. of Microbiology-College of Medicine- University of Baghdad (Clinical Immunology)Rheumatology unit-Dept. of Medicine- University of BaghdadTeaching Laboratories, Medical city (Clinical Immunology.Dept. of Immunology, College of Medicine, Al-Yarmouk University.Background: There is a general acceptance which illustrated that auto antibodies act as a central immunological disturbance in most of the auto immune diseases, among these auto immune diseaselies the SLE Patients and Methods: Thirty five patients with SLE were compared to twenty age and sex matched, control subjects and studied for the presence of auto antibodies, plus IL-4 and IL-6 using Elisa method and immune fluorescent method (for ANA only) Results: Data showed that IL-6 detectable levels were statistically significant in patients with positive anti ds-DNA, but not significant statistically in ANA positive patients although it was detected in 24 (70.6%) of positive ANA patients, while there was no statistically significant correlation between IL- 4 detectable level and autoantibodies production. Conclusion: There is apparently a positive correlation between IL-6 and anti ds DNA production in lupus patients.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1097Autoantibodies, Interleukin-4, Interleukin-6, systemic lupus erythematosus |
| spellingShingle | Sajid N. Abdualkader Abdul- Wahab Al-Shaikly Khalida M. Al-Mousawy Mustafa Al-Ezzi Maan G. Hasso Zena E. Hassan Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus. مجلة كلية الطب Autoantibodies, Interleukin-4, Interleukin-6, systemic lupus erythematosus |
| title | Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus. |
| title_full | Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus. |
| title_fullStr | Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus. |
| title_full_unstemmed | Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus. |
| title_short | Correlation between Interleukin-4 and Interleukin-6 and auto antibodies in Systemic Lupus Erythematosus. |
| title_sort | correlation between interleukin 4 and interleukin 6 and auto antibodies in systemic lupus erythematosus |
| topic | Autoantibodies, Interleukin-4, Interleukin-6, systemic lupus erythematosus |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1097 |
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