The use of urinary Insulin-like Growth Factor-I (IGF-I) for determining skeletal age of participants
Introduction: Biochemical markers play an important role in the growth and repair of bone and can be evaluated in different biological fluids. Therefore, the aim of this study was to evaluate the level of insulin-like growth factor-I (IGF-I) in urine as a puberty index and to compare it with cervica...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2020-03-01
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| Series: | Caspian journal of dental research |
| Subjects: | |
| Online Access: | http://cjdr.ir/article-1-286-en.html |
| _version_ | 1811223869750509568 |
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| author | Hadis Majd valiollah Arash Manouchehr Rahmati Kamel Ali Bijani Mohammad Ali Bayani |
| author_facet | Hadis Majd valiollah Arash Manouchehr Rahmati Kamel Ali Bijani Mohammad Ali Bayani |
| author_sort | Hadis Majd |
| collection | DOAJ |
| description | Introduction: Biochemical markers play an important role in the growth and repair of bone and can be evaluated in different biological fluids. Therefore, the aim of this study was to evaluate the level of insulin-like growth factor-I (IGF-I) in urine as a puberty index and to compare it with cervical vertebral maturational stages (CVMSs) in lateral cephalometry.
Materials&Methods: In this cross-sectional study, 50 8-18-year-old patients (males and females), referred to Faculty of Dentistry with CVMS of 2 to 6 and needed orthodontic treatment as well as lateral cephalometry were selected. All of these patients were healthy. The CVMSs were recorded based on lateral cephalometric radiographs and urinary levels of IGF-I was determined using a urine-based ELISA kit. Mean IGF-I values for each CVMS were analyzed by Mann-Whitney, Kruskal-Wallis and Chi-square tests in SPSS. P<0.05 was statistically considered as significant level.
Results: In this study, the mean age of participants, ranged from 8 to 18 years was 12.96±3.82. There was no statistically significant difference in gender distribution between CVM groups (P=0.106). The level of urinary IGF-I had no significant difference between groups, except for CVMS3 group (P=0.073). In CS3, the mean urinary IGF-I level was 0.2727, representing a significant difference from other groups (P=0.000). IGF-I levels had no significant differences between males (0.03±0.04) and females (0.08±0.011), (P=0.492).
Conclusion: The highest urinary IGF-I level was found in both genders in CVMS 3 and 4, which coincided with peak growth spurt in patients. |
| first_indexed | 2024-04-12T08:40:55Z |
| format | Article |
| id | doaj.art-9eaae3a12b114931b81f9b15ed0ceeec |
| institution | Directory Open Access Journal |
| issn | 2251-9890 2322-2395 |
| language | English |
| last_indexed | 2024-04-12T08:40:55Z |
| publishDate | 2020-03-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian journal of dental research |
| spelling | doaj.art-9eaae3a12b114931b81f9b15ed0ceeec2022-12-22T03:39:54ZengBabol University of Medical SciencesCaspian journal of dental research2251-98902322-23952020-03-01912328The use of urinary Insulin-like Growth Factor-I (IGF-I) for determining skeletal age of participantsHadis Majd0valiollah Arash1Manouchehr Rahmati Kamel2Ali Bijani3Mohammad Ali Bayani4 , Student Research Committee, Babol University of Medical Sciences, Babol, IR Iran. , Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. , Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. , Social Departments of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. , Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, IR Iran. Introduction: Biochemical markers play an important role in the growth and repair of bone and can be evaluated in different biological fluids. Therefore, the aim of this study was to evaluate the level of insulin-like growth factor-I (IGF-I) in urine as a puberty index and to compare it with cervical vertebral maturational stages (CVMSs) in lateral cephalometry. Materials&Methods: In this cross-sectional study, 50 8-18-year-old patients (males and females), referred to Faculty of Dentistry with CVMS of 2 to 6 and needed orthodontic treatment as well as lateral cephalometry were selected. All of these patients were healthy. The CVMSs were recorded based on lateral cephalometric radiographs and urinary levels of IGF-I was determined using a urine-based ELISA kit. Mean IGF-I values for each CVMS were analyzed by Mann-Whitney, Kruskal-Wallis and Chi-square tests in SPSS. P<0.05 was statistically considered as significant level. Results: In this study, the mean age of participants, ranged from 8 to 18 years was 12.96±3.82. There was no statistically significant difference in gender distribution between CVM groups (P=0.106). The level of urinary IGF-I had no significant difference between groups, except for CVMS3 group (P=0.073). In CS3, the mean urinary IGF-I level was 0.2727, representing a significant difference from other groups (P=0.000). IGF-I levels had no significant differences between males (0.03±0.04) and females (0.08±0.011), (P=0.492). Conclusion: The highest urinary IGF-I level was found in both genders in CVMS 3 and 4, which coincided with peak growth spurt in patients.http://cjdr.ir/article-1-286-en.htmlinsulin-like growth factor icervical vertebraeage determination by skeleton |
| spellingShingle | Hadis Majd valiollah Arash Manouchehr Rahmati Kamel Ali Bijani Mohammad Ali Bayani The use of urinary Insulin-like Growth Factor-I (IGF-I) for determining skeletal age of participants Caspian journal of dental research insulin-like growth factor i cervical vertebrae age determination by skeleton |
| title | The use of urinary Insulin-like Growth Factor-I (IGF-I) for determining skeletal age of participants |
| title_full | The use of urinary Insulin-like Growth Factor-I (IGF-I) for determining skeletal age of participants |
| title_fullStr | The use of urinary Insulin-like Growth Factor-I (IGF-I) for determining skeletal age of participants |
| title_full_unstemmed | The use of urinary Insulin-like Growth Factor-I (IGF-I) for determining skeletal age of participants |
| title_short | The use of urinary Insulin-like Growth Factor-I (IGF-I) for determining skeletal age of participants |
| title_sort | use of urinary insulin like growth factor i igf i for determining skeletal age of participants |
| topic | insulin-like growth factor i cervical vertebrae age determination by skeleton |
| url | http://cjdr.ir/article-1-286-en.html |
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