Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases
Cardiometabolic diseases (CMDs) are characterized by a series of metabolic disorders and chronic low-grade inflammation. CMDs contribute to a high burden of mortality and morbidity worldwide. Host-microbial metabolic regulation that triggers metaflammation is an emerging field of study that promotes...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661823003390 |
| _version_ | 1797422651995586560 |
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| author | Anlu Wang Baoyi Guan He Zhang Hao Xu |
| author_facet | Anlu Wang Baoyi Guan He Zhang Hao Xu |
| author_sort | Anlu Wang |
| collection | DOAJ |
| description | Cardiometabolic diseases (CMDs) are characterized by a series of metabolic disorders and chronic low-grade inflammation. CMDs contribute to a high burden of mortality and morbidity worldwide. Host-microbial metabolic regulation that triggers metaflammation is an emerging field of study that promotes a new perspective for perceiving cardiovascular risks. The term metaflammation denotes the entire cascade of immune responses activated by a new class of metabolites known as “danger-associated metabolites” (DAMs). It is being proposed by the present review for the first time. We summarize current studies covering bench to bedside aspects of DAMs to better understand CMDs in the context of DAMs. We have focused on the involvement of DAMs in the pathophysiological development of CMDs, including the disruption of immune homeostasis and chronic inflammation–triggered damage leading to CMD-related adverse events, as well as emerging therapeutic approaches for targeting DAM metabolism in CMDs. |
| first_indexed | 2024-03-09T07:36:27Z |
| format | Article |
| id | doaj.art-9eab2b390b054cb4a99c31b056656c1e |
| institution | Directory Open Access Journal |
| issn | 1096-1186 |
| language | English |
| last_indexed | 2024-03-09T07:36:27Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj.art-9eab2b390b054cb4a99c31b056656c1e2023-12-03T05:39:38ZengElsevierPharmacological Research1096-11862023-12-01198106983Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseasesAnlu Wang0Baoyi Guan1He Zhang2Hao Xu3Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; National Clinical Research Center for Chinese Medicine Cardiology, Beijing 100091, ChinaDepartment of Internal Medicine-Cardiovascular, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510000, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; National Clinical Research Center for Chinese Medicine Cardiology, Beijing 100091, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China; National Clinical Research Center for Chinese Medicine Cardiology, Beijing 100091, China; Corresponding author at: Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.Cardiometabolic diseases (CMDs) are characterized by a series of metabolic disorders and chronic low-grade inflammation. CMDs contribute to a high burden of mortality and morbidity worldwide. Host-microbial metabolic regulation that triggers metaflammation is an emerging field of study that promotes a new perspective for perceiving cardiovascular risks. The term metaflammation denotes the entire cascade of immune responses activated by a new class of metabolites known as “danger-associated metabolites” (DAMs). It is being proposed by the present review for the first time. We summarize current studies covering bench to bedside aspects of DAMs to better understand CMDs in the context of DAMs. We have focused on the involvement of DAMs in the pathophysiological development of CMDs, including the disruption of immune homeostasis and chronic inflammation–triggered damage leading to CMD-related adverse events, as well as emerging therapeutic approaches for targeting DAM metabolism in CMDs.http://www.sciencedirect.com/science/article/pii/S1043661823003390Danger-associated metabolitesCardiometabolic diseasesMetaflammationEmerging therapeutic approaches |
| spellingShingle | Anlu Wang Baoyi Guan He Zhang Hao Xu Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases Pharmacological Research Danger-associated metabolites Cardiometabolic diseases Metaflammation Emerging therapeutic approaches |
| title | Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases |
| title_full | Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases |
| title_fullStr | Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases |
| title_full_unstemmed | Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases |
| title_short | Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases |
| title_sort | danger associated metabolites trigger metaflammation a crowbar in cardiometabolic diseases |
| topic | Danger-associated metabolites Cardiometabolic diseases Metaflammation Emerging therapeutic approaches |
| url | http://www.sciencedirect.com/science/article/pii/S1043661823003390 |
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