Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes
BackgroundLow circulating prolactin hormone was associated with increased risk for type 2 diabetes mellitus. An inverse association of serum prolactin with cardiac remodeling was also previously suggested. Thus, the first question arises whether low serum prolactin is associated with adverse cardiac...
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| Format: | Article |
| Language: | English |
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Korean Diabetes Association
2017-06-01
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| Series: | Diabetes & Metabolism Journal |
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| Online Access: | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-195.pdf |
| _version_ | 1818466899594313728 |
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| author | Mervat M. El-Eshmawy Enas M. Elkhamisy Eman Elsayed Shaheer Kamal |
| author_facet | Mervat M. El-Eshmawy Enas M. Elkhamisy Eman Elsayed Shaheer Kamal |
| author_sort | Mervat M. El-Eshmawy |
| collection | DOAJ |
| description | BackgroundLow circulating prolactin hormone was associated with increased risk for type 2 diabetes mellitus. An inverse association of serum prolactin with cardiac remodeling was also previously suggested. Thus, the first question arises whether low serum prolactin is associated with adverse cardiac remodeling in subjects with prediabetes and if so what the impact of gender is? Second, could serum prolactin be considered a predictor of cardiac morbidity in those subjects? This study was conducted to assess prolactin level variations in relation to echocardiographic indices of cardiac remodeling among adult men and women with prediabetes.MethodsThis cross sectional study enrolled 80 subjects with prediabetic; 40 men and 40 women. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance, white blood cells count, prolactin and echocardiography were assessed.ResultsProlactin was significantly lower in men than in women with prediabetes. Left ventricular mass (LVM) was significantly higher in men than in women with prediabetes. The proportion of left ventricular hypertrophy (LVH) in men with prediabetes was 45% compared with 22.5% in women (P=0.03). We also found inverse independent associations of serum prolactin with LVM and LVH in men, but not in women.ConclusionIn prediabetes, physiologically low serum prolactin is an independent predictor of increased LVM and LVH in adult men, but not in women. Prolactin may be a potential diagnostic biomarker for cardiac remodeling in adult men with prediabetes. |
| first_indexed | 2024-04-13T21:02:57Z |
| format | Article |
| id | doaj.art-9ead59bf3087484f8479aa696b0c3694 |
| institution | Directory Open Access Journal |
| issn | 2233-6079 2233-6087 |
| language | English |
| last_indexed | 2024-04-13T21:02:57Z |
| publishDate | 2017-06-01 |
| publisher | Korean Diabetes Association |
| record_format | Article |
| series | Diabetes & Metabolism Journal |
| spelling | doaj.art-9ead59bf3087484f8479aa696b0c36942022-12-22T02:30:06ZengKorean Diabetes AssociationDiabetes & Metabolism Journal2233-60792233-60872017-06-0141319520410.4093/dmj.2017.41.3.195Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with PrediabetesMervat M. El-Eshmawy0Enas M. Elkhamisy1Eman Elsayed2Shaheer Kamal3Department of Internal Medicine, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Mansoura, Egypt.Department of Internal Medicine, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Mansoura, Egypt.Department of Clinical Pathology, Mansoura University Faculty of Medicine, Mansoura, Egypt.Department of Cardiology, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Mansoura, Egypt.BackgroundLow circulating prolactin hormone was associated with increased risk for type 2 diabetes mellitus. An inverse association of serum prolactin with cardiac remodeling was also previously suggested. Thus, the first question arises whether low serum prolactin is associated with adverse cardiac remodeling in subjects with prediabetes and if so what the impact of gender is? Second, could serum prolactin be considered a predictor of cardiac morbidity in those subjects? This study was conducted to assess prolactin level variations in relation to echocardiographic indices of cardiac remodeling among adult men and women with prediabetes.MethodsThis cross sectional study enrolled 80 subjects with prediabetic; 40 men and 40 women. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance, white blood cells count, prolactin and echocardiography were assessed.ResultsProlactin was significantly lower in men than in women with prediabetes. Left ventricular mass (LVM) was significantly higher in men than in women with prediabetes. The proportion of left ventricular hypertrophy (LVH) in men with prediabetes was 45% compared with 22.5% in women (P=0.03). We also found inverse independent associations of serum prolactin with LVM and LVH in men, but not in women.ConclusionIn prediabetes, physiologically low serum prolactin is an independent predictor of increased LVM and LVH in adult men, but not in women. Prolactin may be a potential diagnostic biomarker for cardiac remodeling in adult men with prediabetes.https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-195.pdfCardiac remodelingGenderPrediabetesProlactin |
| spellingShingle | Mervat M. El-Eshmawy Enas M. Elkhamisy Eman Elsayed Shaheer Kamal Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes Diabetes & Metabolism Journal Cardiac remodeling Gender Prediabetes Prolactin |
| title | Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes |
| title_full | Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes |
| title_fullStr | Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes |
| title_full_unstemmed | Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes |
| title_short | Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes |
| title_sort | impact of gender on the association between low serum prolactin and left ventricular mass in subjects with prediabetes |
| topic | Cardiac remodeling Gender Prediabetes Prolactin |
| url | https://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-41-195.pdf |
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