LIVER TRANSPLANTATION IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTRIC STUDY
ABSTRACT BACKGROUND: The prevalence of primary sclerosing cholangitis (PSC) in the general population has not yet been clearly established. The management of PSC should focus on delaying the progression of the disease and restraining its complications. The only curative therapy for the disease rema...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Colégio Brasileiro de Cirurgia Digestiva
2023-10-01
|
| Series: | ABCD: Arquivos Brasileiros de Cirurgia Digestiva |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202023000100333&tlng=en |
| _version_ | 1797658853495537664 |
|---|---|
| author | Henrique de Aguiar Wiederkehr Julio Cesar Wiederkehr Mauro Rafael Da Igreja Eduardo Brommelstroet Ramos Marcelo Scheidemantel Nogara Debora Stroparo Soffiatti Andrew Massutti Vivian Laís Sasaki Barbara de Aguiar Wiederkehr Igor Raphael Mathias Valejo Júlio Cezar Uili Coelho |
| author_facet | Henrique de Aguiar Wiederkehr Julio Cesar Wiederkehr Mauro Rafael Da Igreja Eduardo Brommelstroet Ramos Marcelo Scheidemantel Nogara Debora Stroparo Soffiatti Andrew Massutti Vivian Laís Sasaki Barbara de Aguiar Wiederkehr Igor Raphael Mathias Valejo Júlio Cezar Uili Coelho |
| author_sort | Henrique de Aguiar Wiederkehr |
| collection | DOAJ |
| description | ABSTRACT BACKGROUND: The prevalence of primary sclerosing cholangitis (PSC) in the general population has not yet been clearly established. The management of PSC should focus on delaying the progression of the disease and restraining its complications. The only curative therapy for the disease remains liver transplantation (LT). PSC is currently the fifth most common indication for LT and corresponds to 5% of all LT indications in adults. AIMS: Our objective is to evaluate the indications and outcomes of PSC patients undergoing LT in three liver transplantation centers in southern Brazil – Hospital Santa Isabel in Blumenau, Santa Catarina state, and Hospital das Clínicas and Hospital Nossa Senhora das Graças, in Curitiba, Parana state). METHODS: This is a longitudinal observational study of patients with PSC who underwent LT in three major Brazilian medical centers. Electronic medical records and study protocols of all patients subjected to LT from January 2011 to December 2021 were retrospectively reviewed. RESULTS: Of the 1,362 transplants performed in the three medical centers, 37 were due to PSC. Recurrence of PSC occurred in three patients (8.1%) in 3.0±2.4 years (range, 1–4 years). The 1-year and 5-year survival rates after the first LT were 83.8 and 80.6%, respectively. The 1-year and 5-year graft survival rates were, respectively, 83.8 and 74.8%. CONCLUSIONS: Our experience with LT in patients with PSC demonstrated good patient and graft survival results. Most deaths were due to common factors in patients undergoing LT. |
| first_indexed | 2024-03-11T18:05:20Z |
| format | Article |
| id | doaj.art-9eadfe112db84ddab9f2de53fb4a78db |
| institution | Directory Open Access Journal |
| issn | 0102-6720 |
| language | English |
| last_indexed | 2024-03-11T18:05:20Z |
| publishDate | 2023-10-01 |
| publisher | Colégio Brasileiro de Cirurgia Digestiva |
| record_format | Article |
| series | ABCD: Arquivos Brasileiros de Cirurgia Digestiva |
| spelling | doaj.art-9eadfe112db84ddab9f2de53fb4a78db2023-10-17T07:41:35ZengColégio Brasileiro de Cirurgia DigestivaABCD: Arquivos Brasileiros de Cirurgia Digestiva0102-67202023-10-013610.1590/0102-672020230051e1769LIVER TRANSPLANTATION IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTRIC STUDYHenrique de Aguiar Wiederkehrhttps://orcid.org/0000-0002-6357-8286Julio Cesar Wiederkehrhttps://orcid.org/0000-0002-5658-2404Mauro Rafael Da Igrejahttps://orcid.org/0009-0003-0716-6089Eduardo Brommelstroet Ramoshttps://orcid.org/0000-0002-7151-9956Marcelo Scheidemantel Nogarahttps://orcid.org/0000-0002-8715-4154Debora Stroparo Soffiattihttps://orcid.org/0009-0007-6382-046XAndrew Massuttihttps://orcid.org/0009-0004-3645-9726Vivian Laís Sasakihttps://orcid.org/0000-0001-7505-1492Barbara de Aguiar Wiederkehrhttps://orcid.org/0009-0006-2027-7658Igor Raphael Mathias Valejohttps://orcid.org/0000-0002-0270-9596Júlio Cezar Uili Coelhohttps://orcid.org/0000-0002-7622-8592ABSTRACT BACKGROUND: The prevalence of primary sclerosing cholangitis (PSC) in the general population has not yet been clearly established. The management of PSC should focus on delaying the progression of the disease and restraining its complications. The only curative therapy for the disease remains liver transplantation (LT). PSC is currently the fifth most common indication for LT and corresponds to 5% of all LT indications in adults. AIMS: Our objective is to evaluate the indications and outcomes of PSC patients undergoing LT in three liver transplantation centers in southern Brazil – Hospital Santa Isabel in Blumenau, Santa Catarina state, and Hospital das Clínicas and Hospital Nossa Senhora das Graças, in Curitiba, Parana state). METHODS: This is a longitudinal observational study of patients with PSC who underwent LT in three major Brazilian medical centers. Electronic medical records and study protocols of all patients subjected to LT from January 2011 to December 2021 were retrospectively reviewed. RESULTS: Of the 1,362 transplants performed in the three medical centers, 37 were due to PSC. Recurrence of PSC occurred in three patients (8.1%) in 3.0±2.4 years (range, 1–4 years). The 1-year and 5-year survival rates after the first LT were 83.8 and 80.6%, respectively. The 1-year and 5-year graft survival rates were, respectively, 83.8 and 74.8%. CONCLUSIONS: Our experience with LT in patients with PSC demonstrated good patient and graft survival results. Most deaths were due to common factors in patients undergoing LT.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202023000100333&tlng=enLiver transplantationCholangitissclerosingLiver cirrhosisbiliary |
| spellingShingle | Henrique de Aguiar Wiederkehr Julio Cesar Wiederkehr Mauro Rafael Da Igreja Eduardo Brommelstroet Ramos Marcelo Scheidemantel Nogara Debora Stroparo Soffiatti Andrew Massutti Vivian Laís Sasaki Barbara de Aguiar Wiederkehr Igor Raphael Mathias Valejo Júlio Cezar Uili Coelho LIVER TRANSPLANTATION IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTRIC STUDY ABCD: Arquivos Brasileiros de Cirurgia Digestiva Liver transplantation Cholangitis sclerosing Liver cirrhosis biliary |
| title | LIVER TRANSPLANTATION IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTRIC STUDY |
| title_full | LIVER TRANSPLANTATION IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTRIC STUDY |
| title_fullStr | LIVER TRANSPLANTATION IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTRIC STUDY |
| title_full_unstemmed | LIVER TRANSPLANTATION IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTRIC STUDY |
| title_short | LIVER TRANSPLANTATION IN PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS: A MULTICENTRIC STUDY |
| title_sort | liver transplantation in patients with primary sclerosing cholangitis a multicentric study |
| topic | Liver transplantation Cholangitis sclerosing Liver cirrhosis biliary |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202023000100333&tlng=en |
| work_keys_str_mv | AT henriquedeaguiarwiederkehr livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy AT juliocesarwiederkehr livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy AT maurorafaeldaigreja livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy AT eduardobrommelstroetramos livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy AT marceloscheidemantelnogara livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy AT deborastroparosoffiatti livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy AT andrewmassutti livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy AT vivianlaissasaki livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy AT barbaradeaguiarwiederkehr livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy AT igorraphaelmathiasvalejo livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy AT juliocezaruilicoelho livertransplantationinpatientswithprimarysclerosingcholangitisamulticentricstudy |