Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2

Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2

Abstract Background Oncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to the metabolic reprogramming of cancer cells by promoting glucose, glutamine, and fatty acid absorption and glycolysis. Lately, sotorasib was ap...

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Bibliographic Details
Main Authors: Dasom Kim, Dongwha Min, Joohee Kim, Min Jung Kim, Yerim Seo, Byung Hwa Jung, Seung‑Hae Kwon, Hyunju Ro, Seoee Lee, Jason K. Sa, Ji-Yun Lee
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
KRAS mutation
GFPT2
HBP
Macropinocytosis
Nutlin-3a
Methuosis
Online Access:https://doi.org/10.1186/s13046-023-02922-8

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