Targeting of the C-Jun/BCL-XL/P21 Axis Accelerates the Switch from Senescence to Apoptosis Upon ROC1 Knockdown in Gastric Cancer Cells

Targeting of the C-Jun/BCL-XL/P21 Axis Accelerates the Switch from Senescence to Apoptosis Upon ROC1 Knockdown in Gastric Cancer Cells

Background/Aims: Regulator of cullins-1 (ROC1) is a pivotal component of cullin-RING E3 ubiquitin ligases, which help to regulate distinct cellular processes by governing the degradation of various substrates. Because the role of ROC1 in gastric cancer is largely uncharacterized, we investigated the...

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Bibliographic Details
Main Authors: Ping Chen, Xiaoting Luo, Zhihui Che, Wenli Zhang, Fuchen Liu, Daisen Hou, Dongqin Yang, Jie Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
ROC1
Gastric cancer
Senescence
Apoptosis
BCL-XL
P21
C-Jun
Online Access:https://www.karger.com/Article/FullText/491979

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