Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity

Synthesis of Isomeric 3-Benzazecines Decorated with Endocyclic Allene Moiety and Exocyclic Conjugated Double Bond and Evaluation of Their Anticholinesterase Activity

Transformations of 1-methoxymethylethynyl substituted isoquinolines triggered by terminal alkynes in alcohols were studied and new 3-benzazecine-containing compounds synthesized, such as 6-methoxymethyl-3-benzazecines incorporating an endocyclic C6–C8 allene fragment and the -ylidene derivatives 6-m...

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Bibliographic Details
Main Authors: Alexander A. Titov, Rosa Purgatorio, Arina Y. Obydennik, Anna V. Listratova, Tatiana N. Borisova, Modesto de Candia, Marco Catto, Cosimo D. Altomare, Alexey V. Varlamov, Leonid G. Voskressensky
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
acetylcholinesterase
butyrylcholinesterase
monoamine oxidase A and B screening
anti-cholinesterase activity
azacyclic allenes
3-benzazecines
Online Access:https://www.mdpi.com/1420-3049/27/19/6276

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https://www.mdpi.com/1420-3049/27/19/6276

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