Displaying the autonomic processing network in humans – a global tractography approach
Regulation of the internal homeostasis is modulated by the central autonomic system. So far, the view of this system is determined by animal and human research focusing on cortical and subcortical grey substance regions. To provide an overview based on white matter architecture, we used a global tra...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-05-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921001294 |
| _version_ | 1818360580366401536 |
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| author | M. Reisert C. Weiller J.A. Hosp |
| author_facet | M. Reisert C. Weiller J.A. Hosp |
| author_sort | M. Reisert |
| collection | DOAJ |
| description | Regulation of the internal homeostasis is modulated by the central autonomic system. So far, the view of this system is determined by animal and human research focusing on cortical and subcortical grey substance regions. To provide an overview based on white matter architecture, we used a global tractography approach to reconstruct a network of tracts interconnecting brain regions that are known to be involved in autonomic processing. Diffusion weighted imaging data were obtained from subjects of the human connectome project (HCP) database. Resulting tracts are in good agreement with previous studies assuming a division of the central autonomic system into a cortical (CAN) and a subcortical network (SAN): the CAN consist of three subsystems that encompass all cerebral lobes and overlap within the insular cortex: a parieto-anterior-temporal pathway (PATP), an occipito-posterior-temporo-frontal pathway (OPTFP) and a limbic pathway. The SAN on the other hand connects the hypothalamus to the periaqueductal grey and locus coeruleus, before it branches into a dorsal and a lateral part that target autonomic nuclei in the rostral medulla oblongata. Our approach furthermore reveals how the CAN and SAN are interconnected: the hypothalamus can be considered as the interface-structure of the SAN, whereas the insula is the central hub of the CAN. The hypothalamus receives input from prefrontal cortical fields but is also connected to the ventral apex of the insular cortex. Thus, a holistic view of the central autonomic system could be created that may promote the understanding of autonomic signaling under physiological and pathophysiological conditions. |
| first_indexed | 2024-12-13T21:03:03Z |
| format | Article |
| id | doaj.art-9eb85a71e8914f549b1c76c7c94ca25b |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-13T21:03:03Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-9eb85a71e8914f549b1c76c7c94ca25b2022-12-21T23:31:34ZengElsevierNeuroImage1095-95722021-05-01231117852Displaying the autonomic processing network in humans – a global tractography approachM. Reisert0C. Weiller1J.A. Hosp2Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Medical Physics, Freiburg University Medical Center, Freiburg, GermanyClinic of Neurology and Neurophysiology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, GermanyClinic of Neurology and Neurophysiology, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Germany; Corresponding author at: University Medical Center Freiburg, Department of Neurology and Neuroscience, Breisacher Str. 64, 79106 Freiburg, Germany.Regulation of the internal homeostasis is modulated by the central autonomic system. So far, the view of this system is determined by animal and human research focusing on cortical and subcortical grey substance regions. To provide an overview based on white matter architecture, we used a global tractography approach to reconstruct a network of tracts interconnecting brain regions that are known to be involved in autonomic processing. Diffusion weighted imaging data were obtained from subjects of the human connectome project (HCP) database. Resulting tracts are in good agreement with previous studies assuming a division of the central autonomic system into a cortical (CAN) and a subcortical network (SAN): the CAN consist of three subsystems that encompass all cerebral lobes and overlap within the insular cortex: a parieto-anterior-temporal pathway (PATP), an occipito-posterior-temporo-frontal pathway (OPTFP) and a limbic pathway. The SAN on the other hand connects the hypothalamus to the periaqueductal grey and locus coeruleus, before it branches into a dorsal and a lateral part that target autonomic nuclei in the rostral medulla oblongata. Our approach furthermore reveals how the CAN and SAN are interconnected: the hypothalamus can be considered as the interface-structure of the SAN, whereas the insula is the central hub of the CAN. The hypothalamus receives input from prefrontal cortical fields but is also connected to the ventral apex of the insular cortex. Thus, a holistic view of the central autonomic system could be created that may promote the understanding of autonomic signaling under physiological and pathophysiological conditions.http://www.sciencedirect.com/science/article/pii/S1053811921001294Central autonomic networkGlobal tractographyHumansInsula |
| spellingShingle | M. Reisert C. Weiller J.A. Hosp Displaying the autonomic processing network in humans – a global tractography approach NeuroImage Central autonomic network Global tractography Humans Insula |
| title | Displaying the autonomic processing network in humans – a global tractography approach |
| title_full | Displaying the autonomic processing network in humans – a global tractography approach |
| title_fullStr | Displaying the autonomic processing network in humans – a global tractography approach |
| title_full_unstemmed | Displaying the autonomic processing network in humans – a global tractography approach |
| title_short | Displaying the autonomic processing network in humans – a global tractography approach |
| title_sort | displaying the autonomic processing network in humans a global tractography approach |
| topic | Central autonomic network Global tractography Humans Insula |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921001294 |
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