Left atrial phasic function remodeling during its enlargement: a two-dimensional speckle-tracking echocardiography study
Abstract Background Left atrial (LA) size is often used as a surrogate marker of LA function in clinical practice, with larger atrial thought to represent a “dysfunctioning” atrium, since there is no accepted ‘gold’ standard to evaluate LA function. The exact relationship between LA size and phasic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-022-02672-z |
| _version_ | 1811341061327421440 |
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| author | Chuyun Chen Ying Yang Wei Ma Litong Qi Baowei Zhang Yan Zhang |
| author_facet | Chuyun Chen Ying Yang Wei Ma Litong Qi Baowei Zhang Yan Zhang |
| author_sort | Chuyun Chen |
| collection | DOAJ |
| description | Abstract Background Left atrial (LA) size is often used as a surrogate marker of LA function in clinical practice, with larger atrial thought to represent a “dysfunctioning” atrium, since there is no accepted ‘gold’ standard to evaluate LA function. The exact relationship between LA size and phasic function, and whether LA dysfunction occur before LA enlargement (LAE) may be of clinical interest while have not been fully studied. Two-dimensional speckle-tracking echocardiography (2D STE) was showed a promising method in measuring LA physical deformation. Materials and methods A community cohort of 715 subjects at cardiovascular disease high risk accepted comprehensive echocardiography. LA longitudinal phasic strain Sa (absolute peak strain during atrial contraction), Se (peak strain at early diastole) and Stot (total atrial strain = Sa + Se), representing contractile, conduit, and reservoir function respectively, were measured using off-line 2D STE software in apical 4 chamber view, and data were compared among groups at different LA size and between subgroups in normal LA size with and without hypertension (HT). Results With LAE (from normal size, mild, moderate to severe LAE), the Stot (21.74 ± 5.97, 20.75 ± 4.99, 20.49 ± 5.27, 17.75 ± 4.71, respectively, ANOVA P = 0.003) and Sa (11.84 ± 3.92, 11.00 ± 3.29, 10.11 ± 2.57, 8.55 ± 2.88, respectively, ANOVA P < 0.001) reduced while Se had no change. Stot of Severe LAE group was significantly lower than that of Normal LA size group (P = 0.002). Sa of the three LAE groups were all significantly lower than that of Normal LA size group (P = 0.024, P = 0.002, P < 0.001, respectively). In normal sized LA subgroups, Stot (21.35 ± 5.91 vs. 23.01 ± 6.02, P = 0.008) and Se (9.51 ± 4.41 vs. 11.17 ± 4.89, P < 0.001) reduced in subjects with HT comparing with those without. Conclusion LA phasic function remodeling occurs before LAE and continues with LAE, with reservoir, conduit and contractile function being affected unparalleled. |
| first_indexed | 2024-04-13T18:51:57Z |
| format | Article |
| id | doaj.art-9eb92040b7094bbe82cd8d6577ff6f29 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-13T18:51:57Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-9eb92040b7094bbe82cd8d6577ff6f292022-12-22T02:34:24ZengBMCBMC Cardiovascular Disorders1471-22612022-05-012211910.1186/s12872-022-02672-zLeft atrial phasic function remodeling during its enlargement: a two-dimensional speckle-tracking echocardiography studyChuyun Chen0Ying Yang1Wei Ma2Litong Qi3Baowei Zhang4Yan Zhang5Department of Cardiology, Peking University First HospitalDepartment of Cardiology, Peking University First HospitalDepartment of Cardiology, Peking University First HospitalDepartment of Cardiology, Peking University First HospitalDepartment of Cardiology, Peking University First HospitalDepartment of Cardiology, Peking University First HospitalAbstract Background Left atrial (LA) size is often used as a surrogate marker of LA function in clinical practice, with larger atrial thought to represent a “dysfunctioning” atrium, since there is no accepted ‘gold’ standard to evaluate LA function. The exact relationship between LA size and phasic function, and whether LA dysfunction occur before LA enlargement (LAE) may be of clinical interest while have not been fully studied. Two-dimensional speckle-tracking echocardiography (2D STE) was showed a promising method in measuring LA physical deformation. Materials and methods A community cohort of 715 subjects at cardiovascular disease high risk accepted comprehensive echocardiography. LA longitudinal phasic strain Sa (absolute peak strain during atrial contraction), Se (peak strain at early diastole) and Stot (total atrial strain = Sa + Se), representing contractile, conduit, and reservoir function respectively, were measured using off-line 2D STE software in apical 4 chamber view, and data were compared among groups at different LA size and between subgroups in normal LA size with and without hypertension (HT). Results With LAE (from normal size, mild, moderate to severe LAE), the Stot (21.74 ± 5.97, 20.75 ± 4.99, 20.49 ± 5.27, 17.75 ± 4.71, respectively, ANOVA P = 0.003) and Sa (11.84 ± 3.92, 11.00 ± 3.29, 10.11 ± 2.57, 8.55 ± 2.88, respectively, ANOVA P < 0.001) reduced while Se had no change. Stot of Severe LAE group was significantly lower than that of Normal LA size group (P = 0.002). Sa of the three LAE groups were all significantly lower than that of Normal LA size group (P = 0.024, P = 0.002, P < 0.001, respectively). In normal sized LA subgroups, Stot (21.35 ± 5.91 vs. 23.01 ± 6.02, P = 0.008) and Se (9.51 ± 4.41 vs. 11.17 ± 4.89, P < 0.001) reduced in subjects with HT comparing with those without. Conclusion LA phasic function remodeling occurs before LAE and continues with LAE, with reservoir, conduit and contractile function being affected unparalleled.https://doi.org/10.1186/s12872-022-02672-zAtrial functionSpeckle trackingHypertensionPhasic functionLeft atrial remodeling |
| spellingShingle | Chuyun Chen Ying Yang Wei Ma Litong Qi Baowei Zhang Yan Zhang Left atrial phasic function remodeling during its enlargement: a two-dimensional speckle-tracking echocardiography study BMC Cardiovascular Disorders Atrial function Speckle tracking Hypertension Phasic function Left atrial remodeling |
| title | Left atrial phasic function remodeling during its enlargement: a two-dimensional speckle-tracking echocardiography study |
| title_full | Left atrial phasic function remodeling during its enlargement: a two-dimensional speckle-tracking echocardiography study |
| title_fullStr | Left atrial phasic function remodeling during its enlargement: a two-dimensional speckle-tracking echocardiography study |
| title_full_unstemmed | Left atrial phasic function remodeling during its enlargement: a two-dimensional speckle-tracking echocardiography study |
| title_short | Left atrial phasic function remodeling during its enlargement: a two-dimensional speckle-tracking echocardiography study |
| title_sort | left atrial phasic function remodeling during its enlargement a two dimensional speckle tracking echocardiography study |
| topic | Atrial function Speckle tracking Hypertension Phasic function Left atrial remodeling |
| url | https://doi.org/10.1186/s12872-022-02672-z |
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