Plasma homocysteine levels associated with a corrected QT interval
Abstract Background Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population. Methods Plasma levels of Hcy were assessed in a population-based study of 7...
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| Format: | Article |
| Language: | English |
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BMC
2017-07-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12872-017-0617-z |
| _version_ | 1818873590896918528 |
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| author | Zhao Li Xiaofan Guo Guozhe Sun Liqiang Zheng Yingxian Sun Yamin Liu Maria Roselle Abraham |
| author_facet | Zhao Li Xiaofan Guo Guozhe Sun Liqiang Zheng Yingxian Sun Yamin Liu Maria Roselle Abraham |
| author_sort | Zhao Li |
| collection | DOAJ |
| description | Abstract Background Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population. Methods Plasma levels of Hcy were assessed in a population-based study of 7002 participants 35 years of age and older from 2012 to 2013. Twelve-lead ECGs were performed on all participants and analyzed automatically. Results The distribution of Hcy levels was determined for an entire population after the data were grouped into quartiles (Q1: <=11.1umol/L; Q2: 11.1–13.8umol/L; Q3: 13.8–18.2 umol/L; Q4 > 18.2 umol/L). The mean value of the QTc interval in each quartile was 433.2 ± 23.8 ms, 430.0 ± 24.6 ms, 429.2 ± 24.5 ms and 430.6 ± 25.7 ms. Multiple logistic regression analyses showed that, compared with the second quartile, and after fully adjusting for potential confounding factors, the odds for QTc > 440 ms in the first and fourth quartile increased (P < 0.05), (OR: 1.23, 95% CI: 1.05–1.43 for Q1; OR: 1.40, 95% CI: 1.19–1.65 for Q4). Conclusions QTc interval was associated with the Hcy level in this general population. |
| first_indexed | 2024-12-19T12:57:08Z |
| format | Article |
| id | doaj.art-9ebced716c864f7aa084e0c30c027cb7 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-12-19T12:57:08Z |
| publishDate | 2017-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-9ebced716c864f7aa084e0c30c027cb72022-12-21T20:20:22ZengBMCBMC Cardiovascular Disorders1471-22612017-07-011711810.1186/s12872-017-0617-zPlasma homocysteine levels associated with a corrected QT intervalZhao Li0Xiaofan Guo1Guozhe Sun2Liqiang Zheng3Yingxian Sun4Yamin Liu5Maria Roselle Abraham6Department of Cardiology, the First Hospital of China Medical UniversityDepartment of Cardiology, the First Hospital of China Medical UniversityDepartment of Cardiology, the First Hospital of China Medical UniversityDepartment of Clinical Epidemiology, Library, Shengjing Hospital of China Medical UniversityDepartment of Cardiology, the First Hospital of China Medical UniversityDepartment of Cardiology, Johns Hopkins UniversityDepartment of Cardiology, Johns Hopkins UniversityAbstract Background Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population. Methods Plasma levels of Hcy were assessed in a population-based study of 7002 participants 35 years of age and older from 2012 to 2013. Twelve-lead ECGs were performed on all participants and analyzed automatically. Results The distribution of Hcy levels was determined for an entire population after the data were grouped into quartiles (Q1: <=11.1umol/L; Q2: 11.1–13.8umol/L; Q3: 13.8–18.2 umol/L; Q4 > 18.2 umol/L). The mean value of the QTc interval in each quartile was 433.2 ± 23.8 ms, 430.0 ± 24.6 ms, 429.2 ± 24.5 ms and 430.6 ± 25.7 ms. Multiple logistic regression analyses showed that, compared with the second quartile, and after fully adjusting for potential confounding factors, the odds for QTc > 440 ms in the first and fourth quartile increased (P < 0.05), (OR: 1.23, 95% CI: 1.05–1.43 for Q1; OR: 1.40, 95% CI: 1.19–1.65 for Q4). Conclusions QTc interval was associated with the Hcy level in this general population.http://link.springer.com/article/10.1186/s12872-017-0617-zHomocysteineCorrected QT intervalMetabolic syndromeCardiovascular disease |
| spellingShingle | Zhao Li Xiaofan Guo Guozhe Sun Liqiang Zheng Yingxian Sun Yamin Liu Maria Roselle Abraham Plasma homocysteine levels associated with a corrected QT interval BMC Cardiovascular Disorders Homocysteine Corrected QT interval Metabolic syndrome Cardiovascular disease |
| title | Plasma homocysteine levels associated with a corrected QT interval |
| title_full | Plasma homocysteine levels associated with a corrected QT interval |
| title_fullStr | Plasma homocysteine levels associated with a corrected QT interval |
| title_full_unstemmed | Plasma homocysteine levels associated with a corrected QT interval |
| title_short | Plasma homocysteine levels associated with a corrected QT interval |
| title_sort | plasma homocysteine levels associated with a corrected qt interval |
| topic | Homocysteine Corrected QT interval Metabolic syndrome Cardiovascular disease |
| url | http://link.springer.com/article/10.1186/s12872-017-0617-z |
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