Cardiac MR fingerprinting with a short acquisition window in consecutive patients referred for clinical CMR and healthy volunteers
Abstract Cardiac Magnetic Resonance Fingerprinting (cMRF) has been demonstrated to enable robust and accurate T1 and T2 mapping for the detection of myocardial fibrosis and edema. However, the relatively long acquisition window (250 ms) used in previous cMRF studies might leave it vulnerable to moti...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-23573-3 |
| _version_ | 1811328661963407360 |
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| author | Simone Rumac Anna Giulia Pavon Jesse I. Hamilton David Rodrigues Nicole Seiberlich Juerg Schwitter Ruud B. van Heeswijk |
| author_facet | Simone Rumac Anna Giulia Pavon Jesse I. Hamilton David Rodrigues Nicole Seiberlich Juerg Schwitter Ruud B. van Heeswijk |
| author_sort | Simone Rumac |
| collection | DOAJ |
| description | Abstract Cardiac Magnetic Resonance Fingerprinting (cMRF) has been demonstrated to enable robust and accurate T1 and T2 mapping for the detection of myocardial fibrosis and edema. However, the relatively long acquisition window (250 ms) used in previous cMRF studies might leave it vulnerable to motion artifacts in patients with high heart rates. The goal of this study was therefore to compare cMRF with a short acquisition window (154 ms) and low-rank reconstruction to routine cardiac T1 and T2 mapping at 1.5 T. Phantom studies showed that the proposed cMRF had a high T1 and T2 accuracy over a wider range than routine mapping techniques. In 9 healthy volunteers, the proposed cMRF showed small but significant myocardial T1 and T2 differences compared to routine mapping (ΔT1 = 1.5%, P = 0.031 and ΔT2 = − 7.1%, P < 0.001). In 61 consecutive patients referred for CMR, the native T1 values were slightly lower (ΔT1 = 1.6%; P = 0.02), while T2 values did not show statistical difference (ΔT2 = 4.3%; P = 0.11). However, the difference was higher in post-contrast myocardial T1 values (ΔT1 = 12.3%; P < 0.001), which was reflected in the extracellular volume (ΔECV = 2.4%; P < 0.001). Across all subjects, the proposed cMRF had a lower precision when compared to routine techniques, although its higher spatial resolution enabled the visualization of smaller details. |
| first_indexed | 2024-04-13T15:28:54Z |
| format | Article |
| id | doaj.art-9ebeff1451cc41e5926ca04213a5fb73 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T15:28:54Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-9ebeff1451cc41e5926ca04213a5fb732022-12-22T02:41:25ZengNature PortfolioScientific Reports2045-23222022-11-0112111310.1038/s41598-022-23573-3Cardiac MR fingerprinting with a short acquisition window in consecutive patients referred for clinical CMR and healthy volunteersSimone Rumac0Anna Giulia Pavon1Jesse I. Hamilton2David Rodrigues3Nicole Seiberlich4Juerg Schwitter5Ruud B. van Heeswijk6Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL)Division of Cardiology, Cardiovascular Department, Cardiac MR Center, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL)Department of Radiology, University of MichiganDepartment of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL)Department of Radiology, University of MichiganDivision of Cardiology, Cardiovascular Department, Cardiac MR Center, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL)Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL)Abstract Cardiac Magnetic Resonance Fingerprinting (cMRF) has been demonstrated to enable robust and accurate T1 and T2 mapping for the detection of myocardial fibrosis and edema. However, the relatively long acquisition window (250 ms) used in previous cMRF studies might leave it vulnerable to motion artifacts in patients with high heart rates. The goal of this study was therefore to compare cMRF with a short acquisition window (154 ms) and low-rank reconstruction to routine cardiac T1 and T2 mapping at 1.5 T. Phantom studies showed that the proposed cMRF had a high T1 and T2 accuracy over a wider range than routine mapping techniques. In 9 healthy volunteers, the proposed cMRF showed small but significant myocardial T1 and T2 differences compared to routine mapping (ΔT1 = 1.5%, P = 0.031 and ΔT2 = − 7.1%, P < 0.001). In 61 consecutive patients referred for CMR, the native T1 values were slightly lower (ΔT1 = 1.6%; P = 0.02), while T2 values did not show statistical difference (ΔT2 = 4.3%; P = 0.11). However, the difference was higher in post-contrast myocardial T1 values (ΔT1 = 12.3%; P < 0.001), which was reflected in the extracellular volume (ΔECV = 2.4%; P < 0.001). Across all subjects, the proposed cMRF had a lower precision when compared to routine techniques, although its higher spatial resolution enabled the visualization of smaller details.https://doi.org/10.1038/s41598-022-23573-3 |
| spellingShingle | Simone Rumac Anna Giulia Pavon Jesse I. Hamilton David Rodrigues Nicole Seiberlich Juerg Schwitter Ruud B. van Heeswijk Cardiac MR fingerprinting with a short acquisition window in consecutive patients referred for clinical CMR and healthy volunteers Scientific Reports |
| title | Cardiac MR fingerprinting with a short acquisition window in consecutive patients referred for clinical CMR and healthy volunteers |
| title_full | Cardiac MR fingerprinting with a short acquisition window in consecutive patients referred for clinical CMR and healthy volunteers |
| title_fullStr | Cardiac MR fingerprinting with a short acquisition window in consecutive patients referred for clinical CMR and healthy volunteers |
| title_full_unstemmed | Cardiac MR fingerprinting with a short acquisition window in consecutive patients referred for clinical CMR and healthy volunteers |
| title_short | Cardiac MR fingerprinting with a short acquisition window in consecutive patients referred for clinical CMR and healthy volunteers |
| title_sort | cardiac mr fingerprinting with a short acquisition window in consecutive patients referred for clinical cmr and healthy volunteers |
| url | https://doi.org/10.1038/s41598-022-23573-3 |
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