The Atherogenic Index of Plasma is a Predictor for Chronic Total Occlusion and Coronary Collateral Circulation Formation in CTOs Patients
Background:The atherogenic index of plasma (AIP), determined by the logarithmic transformation of the ratio of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), was found to be a marker of cardiovascular disease. We sought to investigate the correlation between the atherogenic AIP...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-10-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/24/10/10.31083/j.rcm2410305 |
| _version_ | 1797643477917368320 |
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| author | Ya Li Yujia Feng Ya Zhong Shu Li Jiesheng Lin Peng Fang Jing Wan Min Zhao |
| author_facet | Ya Li Yujia Feng Ya Zhong Shu Li Jiesheng Lin Peng Fang Jing Wan Min Zhao |
| author_sort | Ya Li |
| collection | DOAJ |
| description | Background:The atherogenic index of plasma (AIP), determined by the logarithmic transformation of the ratio of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), was found to be a marker of cardiovascular disease. We sought to investigate the correlation between the atherogenic AIP and coronary collateral circulation (CCC) formation in chronic total occlusive (CTOs) patients. Methods: This retrospective cohort study included 665 non-CTOs and 345 CTOs patients. CTOs were divided into 206 CCC poor formation patients and 139 CCC good formation patients according to the Cohen-Rentrop grade. Spearman correlation analysis was carried out to obtain the relationship between AIP and the Rentrop grade. We used multivariate logistic regression analysis to assess CTOs and CCC poor formation risk factors. Receiver operating characteristic (ROC) curves were used to determine the optimal threshold for AIP to predict CTOs and CCC poor formation. The predicted increment of AIP on CTOs and CCC poor formation was evaluated by calculating the Net Reclassification Index (NRI) and the Integrated Discriminant Index (IDI). Results: AIP in CTOs was significantly elevated compared to non-CTOs patients [(1.55 (1.02, 2.59)) vs (1.26 (0.82, 1.90)), p < 0.001] AIP in the CCC poor formation group was significantly higher than that in the CCC good formation group [(1.73 (1.12, 2.90)) vs (1.37 (0.84, 2.13)), p = 0.002]. There was a negative correlation between AIP and the Rentrop grade (r = –0.145, p = 0.007). The results of multivariate logistic regression revealed that AIP was an independent predictor of CTOs (OR = 4.371, 95% CI: 2.436–7.844, p < 0.001) and CCC poor formation (OR = 3.749, 95% CI: 1.628–8.635, p = 0.002). In the ROC analysis, the area under the curve of AIP for identifying CTOs and CCC poor formation was 0.596 (OR = 3.680, 95% CI: 1.490–9.090, p = 0.005) and 0.597 (95% CI: 0.535–0.658, p = 0.002), respectively. Conclusions: Contrary to previous research, we found that AIP is a moderate but not powerful indicator for detecting both CTO patients and poor CCC formation. |
| first_indexed | 2024-03-11T14:16:26Z |
| format | Article |
| id | doaj.art-9ebfe6436486420ea887681bf673beaa |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-03-11T14:16:26Z |
| publishDate | 2023-10-01 |
| publisher | IMR Press |
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| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-9ebfe6436486420ea887681bf673beaa2023-11-01T06:42:26ZengIMR PressReviews in Cardiovascular Medicine1530-65502023-10-01241030510.31083/j.rcm2410305S1530-6550(23)01089-XThe Atherogenic Index of Plasma is a Predictor for Chronic Total Occlusion and Coronary Collateral Circulation Formation in CTOs PatientsYa Li0Yujia Feng1Ya Zhong2Shu Li3Jiesheng Lin4Peng Fang5Jing Wan6Min Zhao7Department of Cardiology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, ChinaDepartment of Cardiology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, ChinaDepartment of Geratology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, ChinaDepartment of Intensive Care Unit, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, ChinaInstitute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, 85764 Munich, GermanyDepartment of Cardiology, Huangshi 5th Hospital, 435005 Huangshi, Hubei, ChinaDepartment of Cardiology, Zhongnan Hospital of Wuhan University, 430071 Wuhan, Hubei, ChinaDemonstration Center for Experimental Basic Medicine Education, Taikang Medical School (School of Basic Medical Sciences), Wuhan University, 430071 Wuhan, Hubei, ChinaBackground:The atherogenic index of plasma (AIP), determined by the logarithmic transformation of the ratio of triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C), was found to be a marker of cardiovascular disease. We sought to investigate the correlation between the atherogenic AIP and coronary collateral circulation (CCC) formation in chronic total occlusive (CTOs) patients. Methods: This retrospective cohort study included 665 non-CTOs and 345 CTOs patients. CTOs were divided into 206 CCC poor formation patients and 139 CCC good formation patients according to the Cohen-Rentrop grade. Spearman correlation analysis was carried out to obtain the relationship between AIP and the Rentrop grade. We used multivariate logistic regression analysis to assess CTOs and CCC poor formation risk factors. Receiver operating characteristic (ROC) curves were used to determine the optimal threshold for AIP to predict CTOs and CCC poor formation. The predicted increment of AIP on CTOs and CCC poor formation was evaluated by calculating the Net Reclassification Index (NRI) and the Integrated Discriminant Index (IDI). Results: AIP in CTOs was significantly elevated compared to non-CTOs patients [(1.55 (1.02, 2.59)) vs (1.26 (0.82, 1.90)), p < 0.001] AIP in the CCC poor formation group was significantly higher than that in the CCC good formation group [(1.73 (1.12, 2.90)) vs (1.37 (0.84, 2.13)), p = 0.002]. There was a negative correlation between AIP and the Rentrop grade (r = –0.145, p = 0.007). The results of multivariate logistic regression revealed that AIP was an independent predictor of CTOs (OR = 4.371, 95% CI: 2.436–7.844, p < 0.001) and CCC poor formation (OR = 3.749, 95% CI: 1.628–8.635, p = 0.002). In the ROC analysis, the area under the curve of AIP for identifying CTOs and CCC poor formation was 0.596 (OR = 3.680, 95% CI: 1.490–9.090, p = 0.005) and 0.597 (95% CI: 0.535–0.658, p = 0.002), respectively. Conclusions: Contrary to previous research, we found that AIP is a moderate but not powerful indicator for detecting both CTO patients and poor CCC formation.https://www.imrpress.com/journal/RCM/24/10/10.31083/j.rcm2410305atherogenic index of plasmacoronary collateral circulationchronic total occlusive diseasecoronary angiographydiagnosis |
| spellingShingle | Ya Li Yujia Feng Ya Zhong Shu Li Jiesheng Lin Peng Fang Jing Wan Min Zhao The Atherogenic Index of Plasma is a Predictor for Chronic Total Occlusion and Coronary Collateral Circulation Formation in CTOs Patients Reviews in Cardiovascular Medicine atherogenic index of plasma coronary collateral circulation chronic total occlusive disease coronary angiography diagnosis |
| title | The Atherogenic Index of Plasma is a Predictor for Chronic Total Occlusion and Coronary Collateral Circulation Formation in CTOs Patients |
| title_full | The Atherogenic Index of Plasma is a Predictor for Chronic Total Occlusion and Coronary Collateral Circulation Formation in CTOs Patients |
| title_fullStr | The Atherogenic Index of Plasma is a Predictor for Chronic Total Occlusion and Coronary Collateral Circulation Formation in CTOs Patients |
| title_full_unstemmed | The Atherogenic Index of Plasma is a Predictor for Chronic Total Occlusion and Coronary Collateral Circulation Formation in CTOs Patients |
| title_short | The Atherogenic Index of Plasma is a Predictor for Chronic Total Occlusion and Coronary Collateral Circulation Formation in CTOs Patients |
| title_sort | atherogenic index of plasma is a predictor for chronic total occlusion and coronary collateral circulation formation in ctos patients |
| topic | atherogenic index of plasma coronary collateral circulation chronic total occlusive disease coronary angiography diagnosis |
| url | https://www.imrpress.com/journal/RCM/24/10/10.31083/j.rcm2410305 |
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