IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment
The IL-6 cytokine family is a group of signaling molecules with wide expression and function across vertebrates. Each member of the family signals by binding to its specific receptor and at least one molecule of gp130, which is the common transmembrane receptor subunit for the whole group. Signal tr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/3/1809 |
| _version_ | 1797487185641865216 |
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| author | Carla M. Felcher Emilia S. Bogni Edith C. Kordon |
| author_facet | Carla M. Felcher Emilia S. Bogni Edith C. Kordon |
| author_sort | Carla M. Felcher |
| collection | DOAJ |
| description | The IL-6 cytokine family is a group of signaling molecules with wide expression and function across vertebrates. Each member of the family signals by binding to its specific receptor and at least one molecule of gp130, which is the common transmembrane receptor subunit for the whole group. Signal transduction upon stimulation of the receptor complex results in the activation of multiple downstream cascades, among which, in mammary cells, the JAK-STAT3 pathway plays a central role. In this review, we summarize the role of the IL-6 cytokine family—specifically IL-6 itself, LIF, OSM, and IL-11—as relevant players during breast cancer progression. We have compiled evidence indicating that this group of soluble factors may be used for early and more precise breast cancer diagnosis and to design targeted therapy to treat or even prevent metastasis development, particularly to the bone. Expression profiles and possible therapeutic use of their specific receptors in the different breast cancer subtypes are also described. In addition, participation of these cytokines in pathologies of the breast linked to lactation and involution of the gland, as post-partum breast cancer and mastitis, is discussed. |
| first_indexed | 2024-03-09T23:44:00Z |
| format | Article |
| id | doaj.art-9ec1324053384a07b4692f2f7a53e532 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:44:00Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9ec1324053384a07b4692f2f7a53e5322023-11-23T16:46:56ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01233180910.3390/ijms23031809IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and TreatmentCarla M. Felcher0Emilia S. Bogni1Edith C. Kordon2Instituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Universidad de Buenos Aires—Consejo Nacional de Investigaciones Científicas y Técnicas (IFIBYNE-UBA-CONICET), Ciudad Autónoma de Buenos Aires (CABA) 1428, ArgentinaInstituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Universidad de Buenos Aires—Consejo Nacional de Investigaciones Científicas y Técnicas (IFIBYNE-UBA-CONICET), Ciudad Autónoma de Buenos Aires (CABA) 1428, ArgentinaInstituto de Fisiología, Biología Molecular y Neurociencias (IFIBYNE), Universidad de Buenos Aires—Consejo Nacional de Investigaciones Científicas y Técnicas (IFIBYNE-UBA-CONICET), Ciudad Autónoma de Buenos Aires (CABA) 1428, ArgentinaThe IL-6 cytokine family is a group of signaling molecules with wide expression and function across vertebrates. Each member of the family signals by binding to its specific receptor and at least one molecule of gp130, which is the common transmembrane receptor subunit for the whole group. Signal transduction upon stimulation of the receptor complex results in the activation of multiple downstream cascades, among which, in mammary cells, the JAK-STAT3 pathway plays a central role. In this review, we summarize the role of the IL-6 cytokine family—specifically IL-6 itself, LIF, OSM, and IL-11—as relevant players during breast cancer progression. We have compiled evidence indicating that this group of soluble factors may be used for early and more precise breast cancer diagnosis and to design targeted therapy to treat or even prevent metastasis development, particularly to the bone. Expression profiles and possible therapeutic use of their specific receptors in the different breast cancer subtypes are also described. In addition, participation of these cytokines in pathologies of the breast linked to lactation and involution of the gland, as post-partum breast cancer and mastitis, is discussed.https://www.mdpi.com/1422-0067/23/3/1809breast cancerIL-6LIFOSMIL-11mastitis |
| spellingShingle | Carla M. Felcher Emilia S. Bogni Edith C. Kordon IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment International Journal of Molecular Sciences breast cancer IL-6 LIF OSM IL-11 mastitis |
| title | IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment |
| title_full | IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment |
| title_fullStr | IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment |
| title_full_unstemmed | IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment |
| title_short | IL-6 Cytokine Family: A Putative Target for Breast Cancer Prevention and Treatment |
| title_sort | il 6 cytokine family a putative target for breast cancer prevention and treatment |
| topic | breast cancer IL-6 LIF OSM IL-11 mastitis |
| url | https://www.mdpi.com/1422-0067/23/3/1809 |
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