Extracellular Fe2+ and Fe3+ modulate osteocytic viability, expression of SOST, RANKL and FGF23, and fluid flow-induced YAP1 nuclear translocation

Extracellular Fe2+ and Fe3+ modulate osteocytic viability, expression of SOST, RANKL and FGF23, and fluid flow-induced YAP1 nuclear translocation

Abstract Iron overload negatively affects bone mass and strength. However, the impact of iron excess on osteocytes—important bone cells for mechanotransduction and remodeling—is poorly understood. Herein, we examined the effects of iron exposure on osteocytes during their maturation process. We disc...

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Bibliographic Details
Main Authors: Wasutorn Chankamngoen, Saowalak Krungchanuchat, Jirawan Thongbunchoo, Naraporn Sirinonthanawech, Jarinthorn Teerapornpuntakit, Nattapon Panupinthu, Narattaphol Charoenphandhu
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-48436-3

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https://doi.org/10.1038/s41598-023-48436-3

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