Killing capacity analysis of tumor-infiltrating cytotoxic lymphocytes and impact on lymph node metastasis in differentiated papillary carcinoma of thyroid with the BRAF V600E mutation

Killing capacity analysis of tumor-infiltrating cytotoxic lymphocytes and impact on lymph node metastasis in differentiated papillary carcinoma of thyroid with the BRAF V600E mutation

Abstract Background Cytotoxic lymphocytes (CLs) express potent toxins, including perforin (P) and granzyme-B (G), which brings about target cell death. The purpose of this study was to evaluate the killing capacity of tumor-infiltrating CLs by means of P and G analysis, and explore the association w...

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Bibliographic Details
Main Authors: Xiaogang Liu, Honggang Liu, Lu Wang, Yubing Han, Linghong Kong, Xinpeng Zhang
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Diagnostic Pathology
Subjects:
Papillary carcinoma of the thyroid
Cytotoxic lymphocytes
Perforin
Granzyme B
Lymph node metastasis
Online Access:https://doi.org/10.1186/s13000-024-01454-9

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