Efficacy of Pulmonary Rehabilitation in Post-COVID-19: A Systematic Review and Meta-Analysis
Background: This systematic review and meta-analysis examines how pulmonary rehabilitation impacts in patients suffering from subacute and long COVID-19 infections, gauging enhancements in of dyspnea, physical function, quality of life, psychological state (anxiety and depression), and fatigue. Meth...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/8/2213 |
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| author | Erika Meléndez-Oliva Oliver Martínez-Pozas Juan Nicolás Cuenca-Zaldívar Jorge Hugo Villafañe Laura Jiménez-Ortega Eleuterio A. Sánchez-Romero |
| author_facet | Erika Meléndez-Oliva Oliver Martínez-Pozas Juan Nicolás Cuenca-Zaldívar Jorge Hugo Villafañe Laura Jiménez-Ortega Eleuterio A. Sánchez-Romero |
| author_sort | Erika Meléndez-Oliva |
| collection | DOAJ |
| description | Background: This systematic review and meta-analysis examines how pulmonary rehabilitation impacts in patients suffering from subacute and long COVID-19 infections, gauging enhancements in of dyspnea, physical function, quality of life, psychological state (anxiety and depression), and fatigue. Methods: Three electronic databases (PubMed, Web of Science, Cochrane Library) were systematically searched for full-text articles published from inception to January 2023. Randomized, quasi-experimental, and observational studies were included, with adults diagnosed with subacute or long COVID-19 who received pulmonary rehabilitation as intervention. Outcomes related to dyspnea, physical function, quality of life, fatigue, and psychological status were included. Risk of bias was assessed with Cochrane Risk of Bias Tool for Randomized Controlled Trials and Risk of bias in non-randomized studies of intervention. The review was registered before starting in PROSPERO (CRD: 42022373075). Results: Thirty-four studies were included, involving 1970 patients with subacute and long COVID-19. The meta-analysis demonstrated moderate to large effects on dyspnea, physical function, quality of life, and depressive symptoms compared to usual care intervention. No significant differences were found in fatigue compared to usual care, nor in anxiety levels after pulmonary rehabilitation intervention. Conclusions: Pulmonary rehabilitation has the potential to improve health outcomes in patients with subacute and long COVID-19. However, due to the high risk of bias of included studies, conclusions should be taken with caution. |
| first_indexed | 2024-03-11T00:06:42Z |
| format | Article |
| id | doaj.art-9ec391f5630f49b1b32c0d4f004eb24a |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T00:06:42Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-9ec391f5630f49b1b32c0d4f004eb24a2023-11-19T00:21:00ZengMDPI AGBiomedicines2227-90592023-08-01118221310.3390/biomedicines11082213Efficacy of Pulmonary Rehabilitation in Post-COVID-19: A Systematic Review and Meta-AnalysisErika Meléndez-Oliva0Oliver Martínez-Pozas1Juan Nicolás Cuenca-Zaldívar2Jorge Hugo Villafañe3Laura Jiménez-Ortega4Eleuterio A. Sánchez-Romero5Department of Physiotherapy, Faculty of Sport Sciences, European University of Valencia, Pg. de l’Albereda, 7, 46010 Valencia, SpainInterdisciplinary Group on Musculoskeletal Disorders, Faculty of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, SpainInterdisciplinary Group on Musculoskeletal Disorders, Faculty of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, SpainIRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, ItalyDepartment of Psychobiology and Behavioral Sciences Methods, Faculty of Odontology, Complutense University of Madrid, 28040 Madrid, SpainInterdisciplinary Group on Musculoskeletal Disorders, Faculty of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón, SpainBackground: This systematic review and meta-analysis examines how pulmonary rehabilitation impacts in patients suffering from subacute and long COVID-19 infections, gauging enhancements in of dyspnea, physical function, quality of life, psychological state (anxiety and depression), and fatigue. Methods: Three electronic databases (PubMed, Web of Science, Cochrane Library) were systematically searched for full-text articles published from inception to January 2023. Randomized, quasi-experimental, and observational studies were included, with adults diagnosed with subacute or long COVID-19 who received pulmonary rehabilitation as intervention. Outcomes related to dyspnea, physical function, quality of life, fatigue, and psychological status were included. Risk of bias was assessed with Cochrane Risk of Bias Tool for Randomized Controlled Trials and Risk of bias in non-randomized studies of intervention. The review was registered before starting in PROSPERO (CRD: 42022373075). Results: Thirty-four studies were included, involving 1970 patients with subacute and long COVID-19. The meta-analysis demonstrated moderate to large effects on dyspnea, physical function, quality of life, and depressive symptoms compared to usual care intervention. No significant differences were found in fatigue compared to usual care, nor in anxiety levels after pulmonary rehabilitation intervention. Conclusions: Pulmonary rehabilitation has the potential to improve health outcomes in patients with subacute and long COVID-19. However, due to the high risk of bias of included studies, conclusions should be taken with caution.https://www.mdpi.com/2227-9059/11/8/2213COVID-19pulmonary rehabilitationexercise |
| spellingShingle | Erika Meléndez-Oliva Oliver Martínez-Pozas Juan Nicolás Cuenca-Zaldívar Jorge Hugo Villafañe Laura Jiménez-Ortega Eleuterio A. Sánchez-Romero Efficacy of Pulmonary Rehabilitation in Post-COVID-19: A Systematic Review and Meta-Analysis Biomedicines COVID-19 pulmonary rehabilitation exercise |
| title | Efficacy of Pulmonary Rehabilitation in Post-COVID-19: A Systematic Review and Meta-Analysis |
| title_full | Efficacy of Pulmonary Rehabilitation in Post-COVID-19: A Systematic Review and Meta-Analysis |
| title_fullStr | Efficacy of Pulmonary Rehabilitation in Post-COVID-19: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Efficacy of Pulmonary Rehabilitation in Post-COVID-19: A Systematic Review and Meta-Analysis |
| title_short | Efficacy of Pulmonary Rehabilitation in Post-COVID-19: A Systematic Review and Meta-Analysis |
| title_sort | efficacy of pulmonary rehabilitation in post covid 19 a systematic review and meta analysis |
| topic | COVID-19 pulmonary rehabilitation exercise |
| url | https://www.mdpi.com/2227-9059/11/8/2213 |
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