Tumor response to radiotherapy and expression of epidermal growth factor receptor mutation and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement in patients with non-small cell lung cancer
Abstract Background One of the main limitations of radiation therapy is the resistance of tumor cells. This study aimed at evaluating the relationship between the expression of epidermal growth factor receptor (EGFR) and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EM...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-07-01
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| Series: | Journal of the Egyptian National Cancer Institute |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43046-022-00130-7 |
| _version_ | 1818510612753285120 |
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| author | Nadeem M. S. Nagi Yasir A. M. Khair Khamis H. Bakari Mohamed N. Nagi Fabian P. Mghanga |
| author_facet | Nadeem M. S. Nagi Yasir A. M. Khair Khamis H. Bakari Mohamed N. Nagi Fabian P. Mghanga |
| author_sort | Nadeem M. S. Nagi |
| collection | DOAJ |
| description | Abstract Background One of the main limitations of radiation therapy is the resistance of tumor cells. This study aimed at evaluating the relationship between the expression of epidermal growth factor receptor (EGFR) and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) and tumor radiosensitivity in patients with non-small cell lung cancer. Methods Medical case files, pathological results for EGFR and EML4-ALK, and computerized tomography scans of patients with NSCLC treated with thoracic radiation therapy were analyzed. Results The sample size was 101 patients with mean age 58.43 ± 9.89 years. Statistically significant differences were observed in the mean reduction of long tumor diameter during the early treatment phase in EGFR-positive versus EGFR-negative patients (p value = 0.04) and in short tumor diameter during the late treatment phase in EGFR-positive versus EGFR-negative patients (p value = 0.04). Conclusion Patients with overexpression of EGFR mutations are more radiosensitive during the early treatment phase, and EML4-ALK mutations were less radiosensitive regardless of phases. |
| first_indexed | 2024-12-10T23:22:22Z |
| format | Article |
| id | doaj.art-9ec53e4a8a844d8abab3d6ad4d6d8674 |
| institution | Directory Open Access Journal |
| issn | 2589-0409 |
| language | English |
| last_indexed | 2024-12-10T23:22:22Z |
| publishDate | 2022-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Journal of the Egyptian National Cancer Institute |
| spelling | doaj.art-9ec53e4a8a844d8abab3d6ad4d6d86742022-12-22T01:29:41ZengSpringerOpenJournal of the Egyptian National Cancer Institute2589-04092022-07-013411710.1186/s43046-022-00130-7Tumor response to radiotherapy and expression of epidermal growth factor receptor mutation and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement in patients with non-small cell lung cancerNadeem M. S. Nagi0Yasir A. M. Khair1Khamis H. Bakari2Mohamed N. Nagi3Fabian P. Mghanga4Department of Oncology, King Khalid HospitalDepartment of Oncology, King Khalid HospitalDepartment of Radiology and Medical Imaging, College of Health Sciences, University of DodomaDepartment of Oncology, King Khalid HospitalDepartment of Clinical Medicine, Peramiho Institute of Health and Allied SciencesAbstract Background One of the main limitations of radiation therapy is the resistance of tumor cells. This study aimed at evaluating the relationship between the expression of epidermal growth factor receptor (EGFR) and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) and tumor radiosensitivity in patients with non-small cell lung cancer. Methods Medical case files, pathological results for EGFR and EML4-ALK, and computerized tomography scans of patients with NSCLC treated with thoracic radiation therapy were analyzed. Results The sample size was 101 patients with mean age 58.43 ± 9.89 years. Statistically significant differences were observed in the mean reduction of long tumor diameter during the early treatment phase in EGFR-positive versus EGFR-negative patients (p value = 0.04) and in short tumor diameter during the late treatment phase in EGFR-positive versus EGFR-negative patients (p value = 0.04). Conclusion Patients with overexpression of EGFR mutations are more radiosensitive during the early treatment phase, and EML4-ALK mutations were less radiosensitive regardless of phases.https://doi.org/10.1186/s43046-022-00130-7EGFR mutationEML4-ALK mutationLung cancerRadiotherapy |
| spellingShingle | Nadeem M. S. Nagi Yasir A. M. Khair Khamis H. Bakari Mohamed N. Nagi Fabian P. Mghanga Tumor response to radiotherapy and expression of epidermal growth factor receptor mutation and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement in patients with non-small cell lung cancer Journal of the Egyptian National Cancer Institute EGFR mutation EML4-ALK mutation Lung cancer Radiotherapy |
| title | Tumor response to radiotherapy and expression of epidermal growth factor receptor mutation and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement in patients with non-small cell lung cancer |
| title_full | Tumor response to radiotherapy and expression of epidermal growth factor receptor mutation and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement in patients with non-small cell lung cancer |
| title_fullStr | Tumor response to radiotherapy and expression of epidermal growth factor receptor mutation and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement in patients with non-small cell lung cancer |
| title_full_unstemmed | Tumor response to radiotherapy and expression of epidermal growth factor receptor mutation and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement in patients with non-small cell lung cancer |
| title_short | Tumor response to radiotherapy and expression of epidermal growth factor receptor mutation and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement in patients with non-small cell lung cancer |
| title_sort | tumor response to radiotherapy and expression of epidermal growth factor receptor mutation and echinoderm microtubule associated protein like 4 anaplastic lymphoma kinase rearrangement in patients with non small cell lung cancer |
| topic | EGFR mutation EML4-ALK mutation Lung cancer Radiotherapy |
| url | https://doi.org/10.1186/s43046-022-00130-7 |
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