PLK1 inhibition dampens NLRP3 inflammasome–elicited response in inflammatory disease models

PLK1 inhibition dampens NLRP3 inflammasome–elicited response in inflammatory disease models

Unabated activation of the NLR family pyrin domain–containing 3 (NLRP3) inflammasome is linked with the pathogenesis of various inflammatory disorders. Polo-like kinase 1 (PLK1) has been widely studied for its role in mitosis. Here, using both pharmacological and genetic approaches, we demonstrate t...

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Bibliographic Details
Main Authors: Marta Baldrighi, Christian Doreth, Yang Li, Xiaohui Zhao, Emily Warner, Hannah Chenoweth, Kamal Kishore, Yagnesh Umrania, David-Paul Minde, Sarah Thome, Xian Yu, Yuning Lu, Alice Knapton, James Harrison, Murray Clarke, Eicke Latz, Guillermo de Cárcer, Marcos Malumbres, Bernhard Ryffel, Clare Bryant, Jinping Liu, Kathryn S. Lilley, Ziad Mallat, Xuan Li
Format: Article
Language:English
Published: American Society for Clinical Investigation 2023-11-01
Series:The Journal of Clinical Investigation
Subjects:
Cell biology
Immunology
Online Access:https://doi.org/10.1172/JCI162129

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