The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence
Aging and related diseases significantly affect the health and happiness index around the world. Cellular senescence is the basis of physiological aging and is closely related to various senile diseases. AMP-activated protein kinase (AMPK) is associated with both the regulation of cellular energy me...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2023-10-01
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| Series: | Frontiers in Bioscience-Landmark |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/FBL/28/10/10.31083/j.fbl2810250 |
| _version_ | 1797640356673617920 |
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| author | Yukun Han Yifan Liu Yanhua Zhang Wei Wang Tongtong Lv Jinbai Huang Xiaochun Peng |
| author_facet | Yukun Han Yifan Liu Yanhua Zhang Wei Wang Tongtong Lv Jinbai Huang Xiaochun Peng |
| author_sort | Yukun Han |
| collection | DOAJ |
| description | Aging and related diseases significantly affect the health and happiness index around the world. Cellular senescence is the basis of physiological aging and is closely related to various senile diseases. AMP-activated protein kinase (AMPK) is associated with both the regulation of cellular energy metabolism and the regulation of cellular senescence. Another set of proteins, sirtuins, has also been demonstrated to play an important role in cell senescence. However, it is not clear how AMPK and sirtuins coordinate to regulate cellular senescence. Herein, we summarized the role of AMPK and sirtuins in regulating metabolism, repairing DNA damage, and even prolonging human life. We have provided a detailed explanation of the clinical trials relating to the AMPK and sirtuins involved in aging. Systematically analyzing individual senescence genes and developing functional reference notes will aid in understanding the potential mechanisms underlying aging and identify therapeutic targets for both anti-aging interventions and age-related illnesses. |
| first_indexed | 2024-03-11T13:29:40Z |
| format | Article |
| id | doaj.art-9ec5b3863a314a719ad37d3777fad641 |
| institution | Directory Open Access Journal |
| issn | 2768-6701 |
| language | English |
| last_indexed | 2024-03-11T13:29:40Z |
| publishDate | 2023-10-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Frontiers in Bioscience-Landmark |
| spelling | doaj.art-9ec5b3863a314a719ad37d3777fad6412023-11-03T02:31:25ZengIMR PressFrontiers in Bioscience-Landmark2768-67012023-10-01281025010.31083/j.fbl2810250S2768-6701(23)00907-3The Role and Application of the AMPK-Sirtuins Network in Cellular SenescenceYukun Han0Yifan Liu1Yanhua Zhang2Wei Wang3Tongtong Lv4Jinbai Huang5Xiaochun Peng6PET Center of Nuclear Medicine, Department of the First Affiliated Hospital of Yangtze University, and School of Medicine of Yangtze University, 434000 Jingzhou, Hubei, ChinaDepartment of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, 434023 Jingzhou, Hubei, ChinaDepartment of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, 434023 Jingzhou, Hubei, ChinaDepartment of Rehabilitation Radiology, Beijing Rehabilitation Hospital, Capital Medical University, 100144 Beijing, ChinaDepartment of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, 434023 Jingzhou, Hubei, ChinaPET Center of Nuclear Medicine, Department of the First Affiliated Hospital of Yangtze University, and School of Medicine of Yangtze University, 434000 Jingzhou, Hubei, ChinaDepartment of Pathophysiology, School of Basic Medicine, Health Science Center, Yangtze University, 434023 Jingzhou, Hubei, ChinaAging and related diseases significantly affect the health and happiness index around the world. Cellular senescence is the basis of physiological aging and is closely related to various senile diseases. AMP-activated protein kinase (AMPK) is associated with both the regulation of cellular energy metabolism and the regulation of cellular senescence. Another set of proteins, sirtuins, has also been demonstrated to play an important role in cell senescence. However, it is not clear how AMPK and sirtuins coordinate to regulate cellular senescence. Herein, we summarized the role of AMPK and sirtuins in regulating metabolism, repairing DNA damage, and even prolonging human life. We have provided a detailed explanation of the clinical trials relating to the AMPK and sirtuins involved in aging. Systematically analyzing individual senescence genes and developing functional reference notes will aid in understanding the potential mechanisms underlying aging and identify therapeutic targets for both anti-aging interventions and age-related illnesses.https://www.imrpress.com/journal/FBL/28/10/10.31083/j.fbl2810250ampksirtuinsagingmtorsenescence |
| spellingShingle | Yukun Han Yifan Liu Yanhua Zhang Wei Wang Tongtong Lv Jinbai Huang Xiaochun Peng The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence Frontiers in Bioscience-Landmark ampk sirtuins aging mtor senescence |
| title | The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence |
| title_full | The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence |
| title_fullStr | The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence |
| title_full_unstemmed | The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence |
| title_short | The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence |
| title_sort | role and application of the ampk sirtuins network in cellular senescence |
| topic | ampk sirtuins aging mtor senescence |
| url | https://www.imrpress.com/journal/FBL/28/10/10.31083/j.fbl2810250 |
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