Suboptimally controlled asthma in patients treated with inhaled ICS/LABA: prevalence, risk factors, and outcomes
Abstract This observational claims-linked survey study assessed the prevalence of and risk factors for suboptimal asthma control and healthcare utilization in adults with asthma receiving fixed-dose combination (FDC) inhaled corticosteroid/long-acting β2-agonist (ICS/LABA). Commercially insured adul...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-05-01
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| Series: | npj Primary Care Respiratory Medicine |
| Online Access: | https://doi.org/10.1038/s41533-023-00336-9 |
| _version_ | 1797827658152673280 |
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| author | Shiyuan Zhang John White Alyssa Goolsby Hunter David Hinds Andrew Fowler Frances Gardiner David Slade Sharanya Murali Wilhelmine Meeraus |
| author_facet | Shiyuan Zhang John White Alyssa Goolsby Hunter David Hinds Andrew Fowler Frances Gardiner David Slade Sharanya Murali Wilhelmine Meeraus |
| author_sort | Shiyuan Zhang |
| collection | DOAJ |
| description | Abstract This observational claims-linked survey study assessed the prevalence of and risk factors for suboptimal asthma control and healthcare utilization in adults with asthma receiving fixed-dose combination (FDC) inhaled corticosteroid/long-acting β2-agonist (ICS/LABA). Commercially insured adults from the Optum Research Database were invited to complete the Asthma Control Test (ACT) and Asthma Control Questionnaire-6 (ACQ-6). Among participants (N = 428), 36.4% (ACT-assessed) and 55.6% (ACQ-6-assessed) had inadequately controlled asthma. Asthma-related quality of life was worse and asthma-related healthcare resource utilization was higher in poorly controlled asthma. Factors associated with ACT-defined suboptimal asthma control in multivariate analysis included: frequent short-acting β2-agonist (SABA) use, asthma-related outpatient visits, lower treatment adherence, and lower education levels. During follow-up, factors associated with asthma exacerbations and/or high SABA use included: inadequately controlled asthma (ACT-assessed), body mass index ≥30 kg/m2, and high-dose ICS/LABA. Approximately 35–55% of adults with asthma were inadequately controlled despite FDC ICS/LABA; poor control was associated with worse disease outcomes. |
| first_indexed | 2024-04-09T12:51:52Z |
| format | Article |
| id | doaj.art-9ec70a21d1d447318e3d525e58b39873 |
| institution | Directory Open Access Journal |
| issn | 2055-1010 |
| language | English |
| last_indexed | 2024-04-09T12:51:52Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Primary Care Respiratory Medicine |
| spelling | doaj.art-9ec70a21d1d447318e3d525e58b398732023-05-14T11:08:34ZengNature Portfolionpj Primary Care Respiratory Medicine2055-10102023-05-0133111210.1038/s41533-023-00336-9Suboptimally controlled asthma in patients treated with inhaled ICS/LABA: prevalence, risk factors, and outcomesShiyuan Zhang0John White1Alyssa Goolsby Hunter2David Hinds3Andrew Fowler4Frances Gardiner5David Slade6Sharanya Murali7Wilhelmine Meeraus8GSKOptumOptumGSKGSKGSKGSKOptumGSKAbstract This observational claims-linked survey study assessed the prevalence of and risk factors for suboptimal asthma control and healthcare utilization in adults with asthma receiving fixed-dose combination (FDC) inhaled corticosteroid/long-acting β2-agonist (ICS/LABA). Commercially insured adults from the Optum Research Database were invited to complete the Asthma Control Test (ACT) and Asthma Control Questionnaire-6 (ACQ-6). Among participants (N = 428), 36.4% (ACT-assessed) and 55.6% (ACQ-6-assessed) had inadequately controlled asthma. Asthma-related quality of life was worse and asthma-related healthcare resource utilization was higher in poorly controlled asthma. Factors associated with ACT-defined suboptimal asthma control in multivariate analysis included: frequent short-acting β2-agonist (SABA) use, asthma-related outpatient visits, lower treatment adherence, and lower education levels. During follow-up, factors associated with asthma exacerbations and/or high SABA use included: inadequately controlled asthma (ACT-assessed), body mass index ≥30 kg/m2, and high-dose ICS/LABA. Approximately 35–55% of adults with asthma were inadequately controlled despite FDC ICS/LABA; poor control was associated with worse disease outcomes.https://doi.org/10.1038/s41533-023-00336-9 |
| spellingShingle | Shiyuan Zhang John White Alyssa Goolsby Hunter David Hinds Andrew Fowler Frances Gardiner David Slade Sharanya Murali Wilhelmine Meeraus Suboptimally controlled asthma in patients treated with inhaled ICS/LABA: prevalence, risk factors, and outcomes npj Primary Care Respiratory Medicine |
| title | Suboptimally controlled asthma in patients treated with inhaled ICS/LABA: prevalence, risk factors, and outcomes |
| title_full | Suboptimally controlled asthma in patients treated with inhaled ICS/LABA: prevalence, risk factors, and outcomes |
| title_fullStr | Suboptimally controlled asthma in patients treated with inhaled ICS/LABA: prevalence, risk factors, and outcomes |
| title_full_unstemmed | Suboptimally controlled asthma in patients treated with inhaled ICS/LABA: prevalence, risk factors, and outcomes |
| title_short | Suboptimally controlled asthma in patients treated with inhaled ICS/LABA: prevalence, risk factors, and outcomes |
| title_sort | suboptimally controlled asthma in patients treated with inhaled ics laba prevalence risk factors and outcomes |
| url | https://doi.org/10.1038/s41533-023-00336-9 |
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