Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine
Exosomal nanoparticles (exosomes or nanovesicles) are biogenic membrane vesicles secreted by various cell types and represent a conservative mechanism of intercellular and interspecies communication in pro- and eukaryotic organisms. By transporting specific proteins, nucleic acids, and low molecular...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-08-01
|
| Series: | Applied Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3417/12/16/8262 |
| _version_ | 1797432516305485824 |
|---|---|
| author | Yury Shkryl Zhargalma Tsydeneshieva Anton Degtyarenko Yulia Yugay Larissa Balabanova Tatiana Rusapetova Victor Bulgakov |
| author_facet | Yury Shkryl Zhargalma Tsydeneshieva Anton Degtyarenko Yulia Yugay Larissa Balabanova Tatiana Rusapetova Victor Bulgakov |
| author_sort | Yury Shkryl |
| collection | DOAJ |
| description | Exosomal nanoparticles (exosomes or nanovesicles) are biogenic membrane vesicles secreted by various cell types and represent a conservative mechanism of intercellular and interspecies communication in pro- and eukaryotic organisms. By transporting specific proteins, nucleic acids, and low molecular weight metabolites, the exosomes are involved in the regulation of developmental processes, activation of the immune system, and the development of a protective response to stress. Recently, the plant nanovesicles, due to an economical and affordable source of their production, have attracted a lot of attention in the biomedical field. Being a natural transport system, the plant exosomes represent a promising platform in biomedicine for the delivery of molecules of both endogenous and exogenous origin. This review presents current data on the biogenesis of plant exosomes and their composition, as well as mechanisms of their loading with various therapeutic compounds, which are determining factors for their possible practical use. We believe that further research in this area will significantly expand the potential of targeted therapy, particularly targeted gene regulation via the small RNAs, due to the use of plant exosomes in clinical practice. |
| first_indexed | 2024-03-09T10:01:43Z |
| format | Article |
| id | doaj.art-9ec7944cd6c04bb2845d2b72c33c8518 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T10:01:43Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-9ec7944cd6c04bb2845d2b72c33c85182023-12-01T23:22:11ZengMDPI AGApplied Sciences2076-34172022-08-011216826210.3390/app12168262Plant Exosomal Vesicles: Perspective Information Nanocarriers in BiomedicineYury Shkryl0Zhargalma Tsydeneshieva1Anton Degtyarenko2Yulia Yugay3Larissa Balabanova4Tatiana Rusapetova5Victor Bulgakov6Federal Scientific Center of the East Asia Terrestrial Biodiversity of the Far East Branch of Russian Academy of Sciences, 159 Stoletija Str., 690022 Vladivostok, RussiaFederal Scientific Center of the East Asia Terrestrial Biodiversity of the Far East Branch of Russian Academy of Sciences, 159 Stoletija Str., 690022 Vladivostok, RussiaFederal Scientific Center of the East Asia Terrestrial Biodiversity of the Far East Branch of Russian Academy of Sciences, 159 Stoletija Str., 690022 Vladivostok, RussiaFederal Scientific Center of the East Asia Terrestrial Biodiversity of the Far East Branch of Russian Academy of Sciences, 159 Stoletija Str., 690022 Vladivostok, RussiaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, RussiaFederal Scientific Center of the East Asia Terrestrial Biodiversity of the Far East Branch of Russian Academy of Sciences, 159 Stoletija Str., 690022 Vladivostok, RussiaFederal Scientific Center of the East Asia Terrestrial Biodiversity of the Far East Branch of Russian Academy of Sciences, 159 Stoletija Str., 690022 Vladivostok, RussiaExosomal nanoparticles (exosomes or nanovesicles) are biogenic membrane vesicles secreted by various cell types and represent a conservative mechanism of intercellular and interspecies communication in pro- and eukaryotic organisms. By transporting specific proteins, nucleic acids, and low molecular weight metabolites, the exosomes are involved in the regulation of developmental processes, activation of the immune system, and the development of a protective response to stress. Recently, the plant nanovesicles, due to an economical and affordable source of their production, have attracted a lot of attention in the biomedical field. Being a natural transport system, the plant exosomes represent a promising platform in biomedicine for the delivery of molecules of both endogenous and exogenous origin. This review presents current data on the biogenesis of plant exosomes and their composition, as well as mechanisms of their loading with various therapeutic compounds, which are determining factors for their possible practical use. We believe that further research in this area will significantly expand the potential of targeted therapy, particularly targeted gene regulation via the small RNAs, due to the use of plant exosomes in clinical practice.https://www.mdpi.com/2076-3417/12/16/8262exosomestargeted drug deliverymultivesicular bodiesmembrane transport |
| spellingShingle | Yury Shkryl Zhargalma Tsydeneshieva Anton Degtyarenko Yulia Yugay Larissa Balabanova Tatiana Rusapetova Victor Bulgakov Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine Applied Sciences exosomes targeted drug delivery multivesicular bodies membrane transport |
| title | Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine |
| title_full | Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine |
| title_fullStr | Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine |
| title_full_unstemmed | Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine |
| title_short | Plant Exosomal Vesicles: Perspective Information Nanocarriers in Biomedicine |
| title_sort | plant exosomal vesicles perspective information nanocarriers in biomedicine |
| topic | exosomes targeted drug delivery multivesicular bodies membrane transport |
| url | https://www.mdpi.com/2076-3417/12/16/8262 |
| work_keys_str_mv | AT yuryshkryl plantexosomalvesiclesperspectiveinformationnanocarriersinbiomedicine AT zhargalmatsydeneshieva plantexosomalvesiclesperspectiveinformationnanocarriersinbiomedicine AT antondegtyarenko plantexosomalvesiclesperspectiveinformationnanocarriersinbiomedicine AT yuliayugay plantexosomalvesiclesperspectiveinformationnanocarriersinbiomedicine AT larissabalabanova plantexosomalvesiclesperspectiveinformationnanocarriersinbiomedicine AT tatianarusapetova plantexosomalvesiclesperspectiveinformationnanocarriersinbiomedicine AT victorbulgakov plantexosomalvesiclesperspectiveinformationnanocarriersinbiomedicine |