Rational Design of Transcranial Current Stimulation (TCS) through Mechanistic Insights into Cortical Network Dynamics
Transcranial current stimulation (TCS) is a promising method of non-invasive brain stimulation to modulate cortical network dynamics. Preliminary studies have demonstrated the ability of TCS to enhance cognition and reduce symptoms in both neurological and psychiatric illnesses. Despite the encourag...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00804/full |
| _version_ | 1811339909961613312 |
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| author | Flavio eFrohlich Flavio eFrohlich Flavio eFrohlich Flavio eFrohlich Stephen L Schmidt Stephen L Schmidt |
| author_facet | Flavio eFrohlich Flavio eFrohlich Flavio eFrohlich Flavio eFrohlich Stephen L Schmidt Stephen L Schmidt |
| author_sort | Flavio eFrohlich |
| collection | DOAJ |
| description | Transcranial current stimulation (TCS) is a promising method of non-invasive brain stimulation to modulate cortical network dynamics. Preliminary studies have demonstrated the ability of TCS to enhance cognition and reduce symptoms in both neurological and psychiatric illnesses. Despite the encouraging results of these studies, the mechanisms by which TCS and endogenous network dynamics interact remain poorly understood. Here, we propose that the development of the next generation of TCS paradigms with increased efficacy requires such mechanistic understanding of how weak electric fields imposed by TCS interact with the nonlinear dynamics of large-scale cortical networks. We highlight key recent advances in the study of the interaction dynamics between TCS and cortical network activity. In particular, we demonstrate the opportunities provided by an interdisciplinary approach that bridges neurobiology and electrical engineering. We discuss the use of (1) hybrid biological-electronic experimental approaches to disentangle feedback interactions, (2) large-scale computer simulations for the study of weak global perturbations imposed by TCS, and (3) optogenetic manipulations informed by dynamics systems theory to probe network dynamics. Together, we here provide the foundation for the use of rational design for the development of the next generation of TCS neurotherapeutics. |
| first_indexed | 2024-04-13T18:33:25Z |
| format | Article |
| id | doaj.art-9ec903b69a194523ad12f8e7495dc3de |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-04-13T18:33:25Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-9ec903b69a194523ad12f8e7495dc3de2022-12-22T02:34:58ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612013-11-01710.3389/fnhum.2013.0080464911Rational Design of Transcranial Current Stimulation (TCS) through Mechanistic Insights into Cortical Network DynamicsFlavio eFrohlich0Flavio eFrohlich1Flavio eFrohlich2Flavio eFrohlich3Stephen L Schmidt4Stephen L Schmidt5University of North Carolina - Chapel HillUniversity of North Carolina - Chapel HillUniversity of North Carolina - Chapel HillUniversity of North Carolina - Chapel HillUniversity of North Carolina - Chapel HillUniversity of North Carolina - Chapel HillTranscranial current stimulation (TCS) is a promising method of non-invasive brain stimulation to modulate cortical network dynamics. Preliminary studies have demonstrated the ability of TCS to enhance cognition and reduce symptoms in both neurological and psychiatric illnesses. Despite the encouraging results of these studies, the mechanisms by which TCS and endogenous network dynamics interact remain poorly understood. Here, we propose that the development of the next generation of TCS paradigms with increased efficacy requires such mechanistic understanding of how weak electric fields imposed by TCS interact with the nonlinear dynamics of large-scale cortical networks. We highlight key recent advances in the study of the interaction dynamics between TCS and cortical network activity. In particular, we demonstrate the opportunities provided by an interdisciplinary approach that bridges neurobiology and electrical engineering. We discuss the use of (1) hybrid biological-electronic experimental approaches to disentangle feedback interactions, (2) large-scale computer simulations for the study of weak global perturbations imposed by TCS, and (3) optogenetic manipulations informed by dynamics systems theory to probe network dynamics. Together, we here provide the foundation for the use of rational design for the development of the next generation of TCS neurotherapeutics.http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00804/fullComputer SimulationresonanceoptogeneticsBrain Stimulationelectric fieldfeedback control |
| spellingShingle | Flavio eFrohlich Flavio eFrohlich Flavio eFrohlich Flavio eFrohlich Stephen L Schmidt Stephen L Schmidt Rational Design of Transcranial Current Stimulation (TCS) through Mechanistic Insights into Cortical Network Dynamics Frontiers in Human Neuroscience Computer Simulation resonance optogenetics Brain Stimulation electric field feedback control |
| title | Rational Design of Transcranial Current Stimulation (TCS) through Mechanistic Insights into Cortical Network Dynamics |
| title_full | Rational Design of Transcranial Current Stimulation (TCS) through Mechanistic Insights into Cortical Network Dynamics |
| title_fullStr | Rational Design of Transcranial Current Stimulation (TCS) through Mechanistic Insights into Cortical Network Dynamics |
| title_full_unstemmed | Rational Design of Transcranial Current Stimulation (TCS) through Mechanistic Insights into Cortical Network Dynamics |
| title_short | Rational Design of Transcranial Current Stimulation (TCS) through Mechanistic Insights into Cortical Network Dynamics |
| title_sort | rational design of transcranial current stimulation tcs through mechanistic insights into cortical network dynamics |
| topic | Computer Simulation resonance optogenetics Brain Stimulation electric field feedback control |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2013.00804/full |
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