Protuberant Electrode Structures for Subretinal Electrical Stimulation: Modeling, Fabrication and in vivo Evaluation
Many neural interfaces used for therapeutic applications are based on extracellular electrical stimulation to control cell polarization and thus functional activity. Amongst them, retinal implants have been designed to restore visual perception in blind patients affected by photoreceptor degeneratio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-08-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00885/full |
| _version_ | 1818872937326837760 |
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| author | Pedro González Losada Lionel Rousseau Marjorie Grzeskowiak Manon Valet Diep Nguyen Julie Dégardin Elisabeth Dubus Serge Picaud Gaelle Lissorgues |
| author_facet | Pedro González Losada Lionel Rousseau Marjorie Grzeskowiak Manon Valet Diep Nguyen Julie Dégardin Elisabeth Dubus Serge Picaud Gaelle Lissorgues |
| author_sort | Pedro González Losada |
| collection | DOAJ |
| description | Many neural interfaces used for therapeutic applications are based on extracellular electrical stimulation to control cell polarization and thus functional activity. Amongst them, retinal implants have been designed to restore visual perception in blind patients affected by photoreceptor degeneration diseases, such as age-related macular degeneration (AMD) or retinitis pigmentosa (RP). While designing such a neural interface, several aspects must be taken into account, like the stimulation efficiency related to the current distribution within the tissue, the bio-interface optimization to improve resolution and tissue integration, and the material biocompatibility associated with long-term aging. In this study, we investigate the use of original microelectrode geometries for subretinal stimulation. The proposed structures combine the use of 3D wells with protuberant mushroom shaped electrode structures in the bottom, implemented on a flexible substrate that allows the in vivo implantation of the devices. These 3D microelectrode structures were first modeled using finite element analysis. Then, a specific microfabrication process compatible with flexible implants was developed to create the 3D microelectrode structures. These structures were tested in vivo to check the adaptation of the retinal tissue to them. Finally, preliminary in vivo stimulation experiments were performed. |
| first_indexed | 2024-12-19T12:46:45Z |
| format | Article |
| id | doaj.art-9ecb4a203b1241a588e9ea5c99530e6e |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-19T12:46:45Z |
| publishDate | 2019-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-9ecb4a203b1241a588e9ea5c99530e6e2022-12-21T20:20:45ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-08-011310.3389/fnins.2019.00885443433Protuberant Electrode Structures for Subretinal Electrical Stimulation: Modeling, Fabrication and in vivo EvaluationPedro González Losada0Lionel Rousseau1Marjorie Grzeskowiak2Manon Valet3Diep Nguyen4Julie Dégardin5Elisabeth Dubus6Serge Picaud7Gaelle Lissorgues8Laboratory ESYCOM, University Paris Est-ESIEE-MLV, Noisy-le-Grand, FranceLaboratory ESYCOM, University Paris Est-ESIEE-MLV, Noisy-le-Grand, FranceLaboratory ESYCOM, University Paris Est-ESIEE-MLV, Noisy-le-Grand, FranceINSERM, CNRS, Institut de la Vision, Sorbonne Université, Paris, FranceINSERM, CNRS, Institut de la Vision, Sorbonne Université, Paris, FranceINSERM, CNRS, Institut de la Vision, Sorbonne Université, Paris, FranceINSERM, CNRS, Institut de la Vision, Sorbonne Université, Paris, FranceINSERM, CNRS, Institut de la Vision, Sorbonne Université, Paris, FranceLaboratory ESYCOM, University Paris Est-ESIEE-MLV, Noisy-le-Grand, FranceMany neural interfaces used for therapeutic applications are based on extracellular electrical stimulation to control cell polarization and thus functional activity. Amongst them, retinal implants have been designed to restore visual perception in blind patients affected by photoreceptor degeneration diseases, such as age-related macular degeneration (AMD) or retinitis pigmentosa (RP). While designing such a neural interface, several aspects must be taken into account, like the stimulation efficiency related to the current distribution within the tissue, the bio-interface optimization to improve resolution and tissue integration, and the material biocompatibility associated with long-term aging. In this study, we investigate the use of original microelectrode geometries for subretinal stimulation. The proposed structures combine the use of 3D wells with protuberant mushroom shaped electrode structures in the bottom, implemented on a flexible substrate that allows the in vivo implantation of the devices. These 3D microelectrode structures were first modeled using finite element analysis. Then, a specific microfabrication process compatible with flexible implants was developed to create the 3D microelectrode structures. These structures were tested in vivo to check the adaptation of the retinal tissue to them. Finally, preliminary in vivo stimulation experiments were performed.https://www.frontiersin.org/article/10.3389/fnins.2019.00885/fullretinal prosthesesmicrofabrication3D microelectrodeFEMsubretinalelectrical stimulation |
| spellingShingle | Pedro González Losada Lionel Rousseau Marjorie Grzeskowiak Manon Valet Diep Nguyen Julie Dégardin Elisabeth Dubus Serge Picaud Gaelle Lissorgues Protuberant Electrode Structures for Subretinal Electrical Stimulation: Modeling, Fabrication and in vivo Evaluation Frontiers in Neuroscience retinal prostheses microfabrication 3D microelectrode FEM subretinal electrical stimulation |
| title | Protuberant Electrode Structures for Subretinal Electrical Stimulation: Modeling, Fabrication and in vivo Evaluation |
| title_full | Protuberant Electrode Structures for Subretinal Electrical Stimulation: Modeling, Fabrication and in vivo Evaluation |
| title_fullStr | Protuberant Electrode Structures for Subretinal Electrical Stimulation: Modeling, Fabrication and in vivo Evaluation |
| title_full_unstemmed | Protuberant Electrode Structures for Subretinal Electrical Stimulation: Modeling, Fabrication and in vivo Evaluation |
| title_short | Protuberant Electrode Structures for Subretinal Electrical Stimulation: Modeling, Fabrication and in vivo Evaluation |
| title_sort | protuberant electrode structures for subretinal electrical stimulation modeling fabrication and in vivo evaluation |
| topic | retinal prostheses microfabrication 3D microelectrode FEM subretinal electrical stimulation |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00885/full |
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