Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics
Atypical antipsychotics (AAP) or second-generation antipsychotics are the clinical option for schizophrenia treatment during acute psychoses, but they are also indicated for maintenance during lifetime, even though they are being used for other psychiatric conditions in clinical practice such as aff...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00195/full |
| _version_ | 1818303782841221120 |
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| author | Samantha Alvarez-Herrera Raúl Escamilla Oscar Medina-Contreras Ricardo Saracco Yvonne Flores Gabriela Hurtado-Alvarado José Luis Maldonado-García Enrique Becerril-Villanueva Gilberto Pérez-Sánchez Lenin Pavón |
| author_facet | Samantha Alvarez-Herrera Raúl Escamilla Oscar Medina-Contreras Ricardo Saracco Yvonne Flores Gabriela Hurtado-Alvarado José Luis Maldonado-García Enrique Becerril-Villanueva Gilberto Pérez-Sánchez Lenin Pavón |
| author_sort | Samantha Alvarez-Herrera |
| collection | DOAJ |
| description | Atypical antipsychotics (AAP) or second-generation antipsychotics are the clinical option for schizophrenia treatment during acute psychoses, but they are also indicated for maintenance during lifetime, even though they are being used for other psychiatric conditions in clinical practice such as affective disorders and autism spectrum disorder, among others. These drugs are differentiated from typical antipsychotics based on their clinical profile and are a better choice because they cause fewer side effects regarding extrapyramidal symptoms (EPS). Even though they provide clear therapeutic benefits, AAP induce peripheral effects that trigger phenotypic, functional, and systemic changes outside the Central Nervous System (CNS). Metabolic disease is frequently associated with AAP and significantly impacts the patient's quality of life. However, other peripheral changes of clinical relevance are present during AAP treatment, such as alterations in the immune and endocrine systems as well as the intestinal microbiome. These less studied alterations also have a significant impact in the patient's health status. This manuscript aims to revise the peripheral immunological, endocrine, and intestinal microbiome changes induced by AAP consumption recommended in the clinical guidelines for schizophrenia and other psychiatric disorders. |
| first_indexed | 2024-12-13T06:00:17Z |
| format | Article |
| id | doaj.art-9ecc5c2bec6946378e7e65035c450089 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-13T06:00:17Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-9ecc5c2bec6946378e7e65035c4500892022-12-21T23:57:21ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-04-011110.3389/fendo.2020.00195504865Immunoendocrine Peripheral Effects Induced by Atypical AntipsychoticsSamantha Alvarez-Herrera0Raúl Escamilla1Oscar Medina-Contreras2Ricardo Saracco3Yvonne Flores4Gabriela Hurtado-Alvarado5José Luis Maldonado-García6Enrique Becerril-Villanueva7Gilberto Pérez-Sánchez8Lenin Pavón9Laboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, MexicoClínica de Esquizofrenia, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, MexicoLaboratorio de Investigación en Inmunología y Proteómica, Hospital Infantil de México Federico Gómez, Ciudad de México, MexicoClínica de Esquizofrenia, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, MexicoClínica de Esquizofrenia, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, MexicoArea of Neurosciences, Department of Biology of Reproduction, CBS, Universidad Autonoma Metropolitana-Iztapalapa, Mexico City, MexicoLaboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, MexicoLaboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, MexicoLaboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, MexicoLaboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, MexicoAtypical antipsychotics (AAP) or second-generation antipsychotics are the clinical option for schizophrenia treatment during acute psychoses, but they are also indicated for maintenance during lifetime, even though they are being used for other psychiatric conditions in clinical practice such as affective disorders and autism spectrum disorder, among others. These drugs are differentiated from typical antipsychotics based on their clinical profile and are a better choice because they cause fewer side effects regarding extrapyramidal symptoms (EPS). Even though they provide clear therapeutic benefits, AAP induce peripheral effects that trigger phenotypic, functional, and systemic changes outside the Central Nervous System (CNS). Metabolic disease is frequently associated with AAP and significantly impacts the patient's quality of life. However, other peripheral changes of clinical relevance are present during AAP treatment, such as alterations in the immune and endocrine systems as well as the intestinal microbiome. These less studied alterations also have a significant impact in the patient's health status. This manuscript aims to revise the peripheral immunological, endocrine, and intestinal microbiome changes induced by AAP consumption recommended in the clinical guidelines for schizophrenia and other psychiatric disorders.https://www.frontiersin.org/article/10.3389/fendo.2020.00195/fullatypical antipsychotics (AAP)peripheral effectsinflammatory responseendocrine responsemicrobiome |
| spellingShingle | Samantha Alvarez-Herrera Raúl Escamilla Oscar Medina-Contreras Ricardo Saracco Yvonne Flores Gabriela Hurtado-Alvarado José Luis Maldonado-García Enrique Becerril-Villanueva Gilberto Pérez-Sánchez Lenin Pavón Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics Frontiers in Endocrinology atypical antipsychotics (AAP) peripheral effects inflammatory response endocrine response microbiome |
| title | Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics |
| title_full | Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics |
| title_fullStr | Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics |
| title_full_unstemmed | Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics |
| title_short | Immunoendocrine Peripheral Effects Induced by Atypical Antipsychotics |
| title_sort | immunoendocrine peripheral effects induced by atypical antipsychotics |
| topic | atypical antipsychotics (AAP) peripheral effects inflammatory response endocrine response microbiome |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00195/full |
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