A Case of Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B
<img src=" https://s3.amazonaws.com/production.scholastica/article/90983/large/prnano_1012023bg.jpg?1702069910"> A male rural worker with cutaneous leishmaniasis (CL) was initially treated with repeated cycles of Meglumine Antimoniate (Glucantime®) and two cycles of Amphotericin B de...
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| Format: | Article |
| Language: | English |
| Published: |
Andover House Inc.
2023-12-01
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| Series: | Precision Nanomedicine |
| Online Access: | https://doi.org/10.33218/001c.90983 |
| _version_ | 1797351708533194752 |
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| author | María Laura Guzman María Florencia Peralta Marcelo Quipildor Francesca Papera Elvia Mejía Juan José Lauthier Manuela Bono Paola Andrea Barroso María Eugenia Olivera Dolores Catalina Carrer |
| author_facet | María Laura Guzman María Florencia Peralta Marcelo Quipildor Francesca Papera Elvia Mejía Juan José Lauthier Manuela Bono Paola Andrea Barroso María Eugenia Olivera Dolores Catalina Carrer |
| author_sort | María Laura Guzman |
| collection | DOAJ |
| description | <img src=" https://s3.amazonaws.com/production.scholastica/article/90983/large/prnano_1012023bg.jpg?1702069910">
A male rural worker with cutaneous leishmaniasis (CL) was initially treated with repeated cycles of Meglumine Antimoniate (Glucantime®) and two cycles of Amphotericin B deoxycholate during a three-year period. However, the patient remained with two active lesions. An experimental topical treatment with liposomal Miltefosine was tested. The efficacy was determined from the MD’s in-spection of the patient and analysis of the lesions’ photographic images, lesions samples culture, and anti-Leishmania antibodies quantification. The parasites from the patient were isolated. The parasites were typified as Leishmania braziliensis, and their susceptibility to Miltefosine, Meglu-mine Antimoniate, and Amphotericin B was measured. The wound healing was initially good with the topical treatment, but the clinical cure was achieved only with a combination of the topical lipo-somal Miltefosine and intravenous Amphotericin B. Of note, the treatment efficacy was strongly correlated with the degree of stress suffered by the patient. To our knowledge, this is the first report on using a topical Miltefosine formulation on a CL patient. |
| first_indexed | 2024-03-08T13:04:27Z |
| format | Article |
| id | doaj.art-9ecd0a5af2064366979c5b6fc8c1bf1d |
| institution | Directory Open Access Journal |
| issn | 2639-9431 |
| language | English |
| last_indexed | 2024-03-08T13:04:27Z |
| publishDate | 2023-12-01 |
| publisher | Andover House Inc. |
| record_format | Article |
| series | Precision Nanomedicine |
| spelling | doaj.art-9ecd0a5af2064366979c5b6fc8c1bf1d2024-01-18T22:42:26ZengAndover House Inc.Precision Nanomedicine2639-94312023-12-0164A Case of Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin BMaría Laura GuzmanMaría Florencia PeraltaMarcelo QuipildorFrancesca PaperaElvia MejíaJuan José LauthierManuela BonoPaola Andrea BarrosoMaría Eugenia OliveraDolores Catalina Carrer<img src=" https://s3.amazonaws.com/production.scholastica/article/90983/large/prnano_1012023bg.jpg?1702069910"> A male rural worker with cutaneous leishmaniasis (CL) was initially treated with repeated cycles of Meglumine Antimoniate (Glucantime®) and two cycles of Amphotericin B deoxycholate during a three-year period. However, the patient remained with two active lesions. An experimental topical treatment with liposomal Miltefosine was tested. The efficacy was determined from the MD’s in-spection of the patient and analysis of the lesions’ photographic images, lesions samples culture, and anti-Leishmania antibodies quantification. The parasites from the patient were isolated. The parasites were typified as Leishmania braziliensis, and their susceptibility to Miltefosine, Meglu-mine Antimoniate, and Amphotericin B was measured. The wound healing was initially good with the topical treatment, but the clinical cure was achieved only with a combination of the topical lipo-somal Miltefosine and intravenous Amphotericin B. Of note, the treatment efficacy was strongly correlated with the degree of stress suffered by the patient. To our knowledge, this is the first report on using a topical Miltefosine formulation on a CL patient.https://doi.org/10.33218/001c.90983 |
| spellingShingle | María Laura Guzman María Florencia Peralta Marcelo Quipildor Francesca Papera Elvia Mejía Juan José Lauthier Manuela Bono Paola Andrea Barroso María Eugenia Olivera Dolores Catalina Carrer A Case of Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B Precision Nanomedicine |
| title | A Case of Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B |
| title_full | A Case of Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B |
| title_fullStr | A Case of Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B |
| title_full_unstemmed | A Case of Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B |
| title_short | A Case of Cutaneous Leishmaniasis Cured by a Combined Treatment of Topical Miltefosine and Injectable Amphotericin B |
| title_sort | case of cutaneous leishmaniasis cured by a combined treatment of topical miltefosine and injectable amphotericin b |
| url | https://doi.org/10.33218/001c.90983 |
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