Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study
inflammaging is a chronic, sterile, low-grade inflammation that develops with advanced age in the absence of overt infection and may contribute to the pathophysiology of sarcopenia, a progressive and generalized skeletal muscle disorder. Furthermore, a series of biomarkers linked to sarcopenia occur...
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MDPI AG
2022-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/23/7175 |
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| author | Leonardo Augusto Costa Teixeira Jousielle Marcia dos Santos Adriana Netto Parentoni Liliana Pereira Lima Tamiris Campos Duarte Franciane Pereira Brant Camila Danielle Cunha Neves Fabiana Souza Máximo Pereira Núbia Carelli Pereira Avelar Ana Lucia Danielewicz Amanda Aparecida Oliveira Leopoldino Sabrina Paula Costa Arthur Nascimento Arrieiro Luana Aparecida Soares Ana Caroline Negreiros Prates Juliana Nogueira Pontes Nobre Alessandra de Carvalho Bastone Vinicius Cunha de Oliveira Murilo Xavier Oliveira Pedro Henrique Scheidt Figueiredo Henrique Silveira Costa Vanessa Amaral Mendonça Redha Taiar Ana Cristina Rodrigues Lacerda |
| author_facet | Leonardo Augusto Costa Teixeira Jousielle Marcia dos Santos Adriana Netto Parentoni Liliana Pereira Lima Tamiris Campos Duarte Franciane Pereira Brant Camila Danielle Cunha Neves Fabiana Souza Máximo Pereira Núbia Carelli Pereira Avelar Ana Lucia Danielewicz Amanda Aparecida Oliveira Leopoldino Sabrina Paula Costa Arthur Nascimento Arrieiro Luana Aparecida Soares Ana Caroline Negreiros Prates Juliana Nogueira Pontes Nobre Alessandra de Carvalho Bastone Vinicius Cunha de Oliveira Murilo Xavier Oliveira Pedro Henrique Scheidt Figueiredo Henrique Silveira Costa Vanessa Amaral Mendonça Redha Taiar Ana Cristina Rodrigues Lacerda |
| author_sort | Leonardo Augusto Costa Teixeira |
| collection | DOAJ |
| description | inflammaging is a chronic, sterile, low-grade inflammation that develops with advanced age in the absence of overt infection and may contribute to the pathophysiology of sarcopenia, a progressive and generalized skeletal muscle disorder. Furthermore, a series of biomarkers linked to sarcopenia occurrence have emerged. To aid diagnostic and treatment strategies for low muscle mass in sarcopenia and other related conditions, the objective of this work was to investigate potential biomarkers associated with appendicular lean mass in community-dwelling older women. This is a cross-sectional study with 71 older women (75 ± 7 years). Dual-energy X-ray absorptiometry was used to assess body composition. Plasmatic blood levels of adipokines (i.e., adiponectin, leptin, and resistin), tumor necrosis factor (TNF) and soluble receptors (sTNFr1 and sTNFr2), interferon (INF), brain-derived neurotrophic factor (BDNF), and interleukins (IL-2, IL-4, IL-5, IL-6, IL-8, and IL-10) were determined by enzyme-linked immunosorbent assay. Older women with low muscle mass showed higher plasma levels of adiponectin, sTNFr1, and IL-8 compared to the regular muscle mass group. In addition, higher adiponectin plasma levels explained 14% of the lower appendicular lean mass. High adiponectin plasmatic blood levels can contribute to lower appendicular lean mass in older, community-dwelling women. |
| first_indexed | 2024-03-09T17:43:48Z |
| format | Article |
| id | doaj.art-9ece5f6da0564c8d9340ecdb40440412 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T17:43:48Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-9ece5f6da0564c8d9340ecdb404404122023-11-24T11:24:08ZengMDPI AGJournal of Clinical Medicine2077-03832022-12-011123717510.3390/jcm11237175Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional StudyLeonardo Augusto Costa Teixeira0Jousielle Marcia dos Santos1Adriana Netto Parentoni2Liliana Pereira Lima3Tamiris Campos Duarte4Franciane Pereira Brant5Camila Danielle Cunha Neves6Fabiana Souza Máximo Pereira7Núbia Carelli Pereira Avelar8Ana Lucia Danielewicz9Amanda Aparecida Oliveira Leopoldino10Sabrina Paula Costa11Arthur Nascimento Arrieiro12Luana Aparecida Soares13Ana Caroline Negreiros Prates14Juliana Nogueira Pontes Nobre15Alessandra de Carvalho Bastone16Vinicius Cunha de Oliveira17Murilo Xavier Oliveira18Pedro Henrique Scheidt Figueiredo19Henrique Silveira Costa20Vanessa Amaral Mendonça21Redha Taiar22Ana Cristina Rodrigues Lacerda23Physiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPostgraduate Program in Health Sciences (PPGCS), Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina 39803-371, BrazilDepartment of Health Sciences, University of Santa Catarina (UFSC), Araranguá 88040-900, BrazilDepartment of Health Sciences, University of Santa Catarina (UFSC), Araranguá 88040-900, BrazilPostgraduate Program in Health Sciences, Faculty of Medical Science of Minas (FCMMG), Belo Horizonte 30130-110, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPostgraduate Multicenter Program in Physiological Sciences (PPGCF), Federal University of Jequitinhonha and Mucuri Valleys (UFVJM), Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilPhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, BrazilMATériaux et Ingénierie Mécanique (MATIM), Université de Reims Champagne-Ardenne, 51100 Reims, FrancePhysiotherapy Department, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39803-371, Brazilinflammaging is a chronic, sterile, low-grade inflammation that develops with advanced age in the absence of overt infection and may contribute to the pathophysiology of sarcopenia, a progressive and generalized skeletal muscle disorder. Furthermore, a series of biomarkers linked to sarcopenia occurrence have emerged. To aid diagnostic and treatment strategies for low muscle mass in sarcopenia and other related conditions, the objective of this work was to investigate potential biomarkers associated with appendicular lean mass in community-dwelling older women. This is a cross-sectional study with 71 older women (75 ± 7 years). Dual-energy X-ray absorptiometry was used to assess body composition. Plasmatic blood levels of adipokines (i.e., adiponectin, leptin, and resistin), tumor necrosis factor (TNF) and soluble receptors (sTNFr1 and sTNFr2), interferon (INF), brain-derived neurotrophic factor (BDNF), and interleukins (IL-2, IL-4, IL-5, IL-6, IL-8, and IL-10) were determined by enzyme-linked immunosorbent assay. Older women with low muscle mass showed higher plasma levels of adiponectin, sTNFr1, and IL-8 compared to the regular muscle mass group. In addition, higher adiponectin plasma levels explained 14% of the lower appendicular lean mass. High adiponectin plasmatic blood levels can contribute to lower appendicular lean mass in older, community-dwelling women.https://www.mdpi.com/2077-0383/11/23/7175agingappendicular muscle massinflammagingbiomarkersadiponectinsarcopenia |
| spellingShingle | Leonardo Augusto Costa Teixeira Jousielle Marcia dos Santos Adriana Netto Parentoni Liliana Pereira Lima Tamiris Campos Duarte Franciane Pereira Brant Camila Danielle Cunha Neves Fabiana Souza Máximo Pereira Núbia Carelli Pereira Avelar Ana Lucia Danielewicz Amanda Aparecida Oliveira Leopoldino Sabrina Paula Costa Arthur Nascimento Arrieiro Luana Aparecida Soares Ana Caroline Negreiros Prates Juliana Nogueira Pontes Nobre Alessandra de Carvalho Bastone Vinicius Cunha de Oliveira Murilo Xavier Oliveira Pedro Henrique Scheidt Figueiredo Henrique Silveira Costa Vanessa Amaral Mendonça Redha Taiar Ana Cristina Rodrigues Lacerda Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study Journal of Clinical Medicine aging appendicular muscle mass inflammaging biomarkers adiponectin sarcopenia |
| title | Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study |
| title_full | Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study |
| title_fullStr | Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study |
| title_full_unstemmed | Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study |
| title_short | Adiponectin Is a Contributing Factor of Low Appendicular Lean Mass in Older Community-Dwelling Women: A Cross-Sectional Study |
| title_sort | adiponectin is a contributing factor of low appendicular lean mass in older community dwelling women a cross sectional study |
| topic | aging appendicular muscle mass inflammaging biomarkers adiponectin sarcopenia |
| url | https://www.mdpi.com/2077-0383/11/23/7175 |
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