Chemopreventive effects and anti-tumorigenic mechanisms of Actinidia arguta, known as sarunashi in Japan toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- induced lung tumorigenesis in a/J mouse

Chemopreventive effects and anti-tumorigenic mechanisms of Actinidia arguta, known as sarunashi in Japan toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- induced lung tumorigenesis in a/J mouse

Abstract Background Previously, we reported the inhibitory effect of Actinidia arguta juice, known as sarunashi juice (sar-j) in Japan, on mutagenesis, inflammation, and mouse skin tumorigenesis. The components of A. arguta responsible for the anti-mutagenic effects were identified to be water-solub...

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Bibliographic Details
Main Authors: Jun Takata, Naoko Miyake, Yusuke Saiki, Misako Tada, Kensuke Sasaki, Toshio Kubo, Katsuyuki Kiura, Sakae Arimoto-Kobayashi
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Genes and Environment
Subjects:
Akt signal transduction
Lung tumorigenesis
Anti-mutagenesis
DNA methylation
Tobacco-specific nitrosamine
Isoquercetin
Online Access:https://doi.org/10.1186/s41021-022-00255-0

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