Oral anti-diabetics for gestational diabetes mellitus – where do we stand?
Background. Oral anti-diabetics in the treatment of gestational diabetes mellitus have had different approaches among time in medical guidelines. The interest in this pregnancy-associated disease is due to the dramatic increase of rates of gestational diabetes but also to the significantly higher sh...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Amaltea Medical Publishing House
2020-09-01
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| Series: | Romanian Medical Journal |
| Subjects: | |
| Online Access: | https://rmj.com.ro/articles/2020.3/RMJ_2020_3_Art-02.pdf |
| _version_ | 1797335070993809408 |
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| author | Delia Cudalba Corina Gica Radu Botezatu Nicolae Gica Anca Marina Ciobanu Gheorghe Peltecu Anca Maria Panaitescu |
| author_facet | Delia Cudalba Corina Gica Radu Botezatu Nicolae Gica Anca Marina Ciobanu Gheorghe Peltecu Anca Maria Panaitescu |
| author_sort | Delia Cudalba |
| collection | DOAJ |
| description | Background. Oral anti-diabetics in the treatment of gestational diabetes mellitus have had different approaches among time in medical guidelines. The interest in this pregnancy-associated disease is due to the dramatic increase of rates of gestational diabetes but also to the significantly higher short-term and longterm implications for mother and off-spring. This article aims to review the literature and guidelines on current recommendations regarding oral therapy in gestational diabetes mellitus. Methods. A systematic literature electronic search for reviews and guidelines was undertaken using Pub Med and the official websites of Diabetes and Obstetrics and Gynecology associations. Conclusions. Whereas oral anti-diabetics are an attractive alternative approach to insulin, in the last guidelines published by the societies of Obstetrics and Gynecology and Diabetes a new trend is noticeable subtracting oral anti-diabetics as the first option because of the lack in high-quality data on long-term safety,
higher rate of treatment failure and pharmacokinetics. |
| first_indexed | 2024-03-08T08:30:37Z |
| format | Article |
| id | doaj.art-9ecec656fbb141f3980505df7a0d1f03 |
| institution | Directory Open Access Journal |
| issn | 1220-5478 2069-606X |
| language | English |
| last_indexed | 2024-03-08T08:30:37Z |
| publishDate | 2020-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Medical Journal |
| spelling | doaj.art-9ecec656fbb141f3980505df7a0d1f032024-02-02T03:12:25ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2020-09-0167324624910.37897/RMJ.2020.3.2Oral anti-diabetics for gestational diabetes mellitus – where do we stand?Delia Cudalba0Corina Gica1Radu Botezatu2 Nicolae Gica3Anca Marina Ciobanu4Gheorghe Peltecu5Anca Maria Panaitescu6“Filantropia“ Clinical Hospital, Bucharest, Romania“Filantropia“ Clinical Hospital, Bucharest, Romania“Filantropia“ Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Filantropia“ Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Filantropia“ Clinical Hospital, Bucharest, Romania“Filantropia“ Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania“Filantropia“ Clinical Hospital, Bucharest, Romania; “Carol Davila” University of Medicine and Pharmacy, Bucharest, RomaniaBackground. Oral anti-diabetics in the treatment of gestational diabetes mellitus have had different approaches among time in medical guidelines. The interest in this pregnancy-associated disease is due to the dramatic increase of rates of gestational diabetes but also to the significantly higher short-term and longterm implications for mother and off-spring. This article aims to review the literature and guidelines on current recommendations regarding oral therapy in gestational diabetes mellitus. Methods. A systematic literature electronic search for reviews and guidelines was undertaken using Pub Med and the official websites of Diabetes and Obstetrics and Gynecology associations. Conclusions. Whereas oral anti-diabetics are an attractive alternative approach to insulin, in the last guidelines published by the societies of Obstetrics and Gynecology and Diabetes a new trend is noticeable subtracting oral anti-diabetics as the first option because of the lack in high-quality data on long-term safety, higher rate of treatment failure and pharmacokinetics.https://rmj.com.ro/articles/2020.3/RMJ_2020_3_Art-02.pdfgestational diabetes mellitusoral anti-diabeticsinsulinmetforminglibenclamide |
| spellingShingle | Delia Cudalba Corina Gica Radu Botezatu Nicolae Gica Anca Marina Ciobanu Gheorghe Peltecu Anca Maria Panaitescu Oral anti-diabetics for gestational diabetes mellitus – where do we stand? Romanian Medical Journal gestational diabetes mellitus oral anti-diabetics insulin metformin glibenclamide |
| title | Oral anti-diabetics for gestational diabetes mellitus – where do we stand? |
| title_full | Oral anti-diabetics for gestational diabetes mellitus – where do we stand? |
| title_fullStr | Oral anti-diabetics for gestational diabetes mellitus – where do we stand? |
| title_full_unstemmed | Oral anti-diabetics for gestational diabetes mellitus – where do we stand? |
| title_short | Oral anti-diabetics for gestational diabetes mellitus – where do we stand? |
| title_sort | oral anti diabetics for gestational diabetes mellitus where do we stand |
| topic | gestational diabetes mellitus oral anti-diabetics insulin metformin glibenclamide |
| url | https://rmj.com.ro/articles/2020.3/RMJ_2020_3_Art-02.pdf |
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