Characteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005–2022
Abstract Background Edwardsiella tarda is a member of Enterobacteriaceae isolated from freshwater and sea. E. tarda infection in humans commonly causes gastroenteritis, but rarely causes bacteremia. However, few studies have described the clinical features of E. tarda bacteremia (ETB); therefore, we...
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12941-022-00548-w |
| _version_ | 1811301894053691392 |
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| author | Kohei Hasegawa Murata Kenya Kumiko Suzuki Yoshihiko Ogawa |
| author_facet | Kohei Hasegawa Murata Kenya Kumiko Suzuki Yoshihiko Ogawa |
| author_sort | Kohei Hasegawa |
| collection | DOAJ |
| description | Abstract Background Edwardsiella tarda is a member of Enterobacteriaceae isolated from freshwater and sea. E. tarda infection in humans commonly causes gastroenteritis, but rarely causes bacteremia. However, few studies have described the clinical features of E. tarda bacteremia (ETB); therefore, we conducted a case review in our hospital. Methods We conducted a single-center, retrospective descriptive study using electronic medical records. Patient and microbial features were extracted and evaluated for 30- and 90-day mortality rates. Results From April 2005 to April 2022, the total set of blood cultures positive for any microorganisms was 9368, 38 of which were positive for E. tarda. Underlying cancer was observed in 65.8% of patients. The most common source of bacteremia was cholangitis, followed by cholecystitis, and endoscopic or surgical drainage was performed in almost all cases. Diarrhea was observed in only one patient, and there were no cases in which gastroenteritis was the source of bacteremia. All cases, except for one, were susceptible to all β-lactams, such as ampicillin. The 30- and 90-day overall mortality rates were 8.6% (3/35) and 25.8% (8/31). Of these, 75% patients died because of cancer progression after successful ETB treatment. Conclusion ETB may occur in patients with malignant underlying conditions. Biliary tract infections are common in ETB cases, whereas gastroenteritis may be an atypical cause of bacteremia. This study suggests that although the mortality rate for ETB at 30 day was low, it increased at 90 day as a result of the development of unfavorable underlying conditions. |
| first_indexed | 2024-04-13T07:17:00Z |
| format | Article |
| id | doaj.art-9ecef083583f4718b13cde6ca5b43607 |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-04-13T07:17:00Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-9ecef083583f4718b13cde6ca5b436072022-12-22T02:56:43ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112022-12-0121111210.1186/s12941-022-00548-wCharacteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005–2022Kohei Hasegawa0Murata Kenya1Kumiko Suzuki2Yoshihiko Ogawa3Department of Infectious Diseases, Sakai City Medical CenterDepartment of Infectious Diseases, Sakai City Medical CenterDepartment of Clinical Laboratory, Sakai City Medical CenterDepartment of Infectious Diseases, Sakai City Medical CenterAbstract Background Edwardsiella tarda is a member of Enterobacteriaceae isolated from freshwater and sea. E. tarda infection in humans commonly causes gastroenteritis, but rarely causes bacteremia. However, few studies have described the clinical features of E. tarda bacteremia (ETB); therefore, we conducted a case review in our hospital. Methods We conducted a single-center, retrospective descriptive study using electronic medical records. Patient and microbial features were extracted and evaluated for 30- and 90-day mortality rates. Results From April 2005 to April 2022, the total set of blood cultures positive for any microorganisms was 9368, 38 of which were positive for E. tarda. Underlying cancer was observed in 65.8% of patients. The most common source of bacteremia was cholangitis, followed by cholecystitis, and endoscopic or surgical drainage was performed in almost all cases. Diarrhea was observed in only one patient, and there were no cases in which gastroenteritis was the source of bacteremia. All cases, except for one, were susceptible to all β-lactams, such as ampicillin. The 30- and 90-day overall mortality rates were 8.6% (3/35) and 25.8% (8/31). Of these, 75% patients died because of cancer progression after successful ETB treatment. Conclusion ETB may occur in patients with malignant underlying conditions. Biliary tract infections are common in ETB cases, whereas gastroenteritis may be an atypical cause of bacteremia. This study suggests that although the mortality rate for ETB at 30 day was low, it increased at 90 day as a result of the development of unfavorable underlying conditions.https://doi.org/10.1186/s12941-022-00548-wEdwardsiella tardaZoonosisBacteremiaEpidemiologyHepatobiliary infection |
| spellingShingle | Kohei Hasegawa Murata Kenya Kumiko Suzuki Yoshihiko Ogawa Characteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005–2022 Annals of Clinical Microbiology and Antimicrobials Edwardsiella tarda Zoonosis Bacteremia Epidemiology Hepatobiliary infection |
| title | Characteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005–2022 |
| title_full | Characteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005–2022 |
| title_fullStr | Characteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005–2022 |
| title_full_unstemmed | Characteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005–2022 |
| title_short | Characteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005–2022 |
| title_sort | characteristics and prognosis of patients with edwardsiella tarda bacteremia at a single institution japan 2005 2022 |
| topic | Edwardsiella tarda Zoonosis Bacteremia Epidemiology Hepatobiliary infection |
| url | https://doi.org/10.1186/s12941-022-00548-w |
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